Imperial College London
Alternate

ProfessorMarkJohnson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Chair in Obstetrics
 
 
 
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Contact

 

+44 (0)20 3315 7887mark.johnson

 
 
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Location

 

H3.35Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dos:2020:10.1177/1753495X20924937,
author = {Dos, Santos F and Baris, L and Varley, A and Cornette, E and Allam, J and Steer, P and Swan, L and Gatzoulis, M and Roos-Hesselink, J and Johnson, MR},
doi = {10.1177/1753495X20924937},
journal = {Obstetric Medicine},
pages = {95--101},
title = {Mechanical heart valves and pregnancy: Issues surrounding anticoagulation. Experience from two obstetric cardiac centres},
url = {http://dx.doi.org/10.1177/1753495X20924937},
volume = {14},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundPregnant women with mechanical heart valves are at significant risk of obstetric/cardiac complications. This study compares the anticoagulation management in two obstetric cardiac centres.MethodsRetrospective case-note review from Chelsea and Westminster/Royal Brompton Hospitals (CR) and Erasmus Medical Centre (EMC). Main outcome measure was mechanical heart valve thrombosis.ResultsNineteen pregnancies from CR and 25 pregnancies from EMC were included. Most women were on low-molecular-weight heparin (LMWH) throughout pregnancy at CR, whereas at EMC most had LMWH in the first trimester and vitamin K antagonists in subsequent trimesters. Peak anti-factor Xa were performed monthly at CR, levels 0.39–1.51 IU/mL (mean 0.82 IU/mL). Anticoagulation management peri-partum was inconsistent. Delivery was mainly by Caesarean section at CR (74%) and vaginal delivery at EMC (64%). No maternal deaths and only one mechanical heart valve thrombosis at CR. Two mechanical heart valve thromboses and one maternal death at EMC.ConclusionPeri-partum anticoagulation strategies, anticoagulation monitoring and mode of delivery inconsistencies reported.
AU  - Dos,Santos F
AU  - Baris,L
AU  - Varley,A
AU  - Cornette,E
AU  - Allam,J
AU  - Steer,P
AU  - Swan,L
AU  - Gatzoulis,M
AU  - Roos-Hesselink,J
AU  - Johnson,MR
DO  - 10.1177/1753495X20924937
EP  - 101
PY  - 2020///
SN  - 1753-495X
SP  - 95
TI  - Mechanical heart valves and pregnancy: Issues surrounding anticoagulation. Experience from two obstetric cardiac centres
T2  - Obstetric Medicine
UR  - http://dx.doi.org/10.1177/1753495X20924937
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000537488500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.sagepub.com/doi/10.1177/1753495X20924937
UR  - http://hdl.handle.net/10044/1/80174
VL  - 14
ER  -
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