Imperial College London

DrMarkRosenberg

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Research Fellow
 
 
 
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Contact

 

mark.rosenberg

 
 
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Location

 

Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Mark Rosenberg is a Research Fellow in Computational and Systems Medicine, Department of Surgery and Cancer.

 

Research Interests:

Structural biology of challenging membrane proteins.

  • Optimizing expression systems for the generation of membrane proteins.
  • Crystallising membrane proteins of medical interest for 3-D structure determination for the purposes of drug design.
  • Crystallization of membrane proteins related to cancer therapy and cystic fibrosis.
  • Design of new methodology for the production of high-quality two-dimensional crystals for cryo-electron microscopy.

 

 

FELLOWSHIPS

EMBO Travel Fellowship to the Max Plank Institute, Frankfurt, Germany.

Royal Society Travel Fellowship to the University of Queens, Kingston, Ontario, Canada.

AWARDS

British Council Award to conduct collaboration at the Pasteur Institute (Paris).

RESEARCH

Dr Rosenberg has determined the first three-dimensional structures of P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1) and the cystic fibrosis transmembrane conductance regulator (CFTR).

COLABORATORS

Professor John Riordan, University of North Carolina, USA.

Dr Qincheng Mao, Washington University, USA.

Professor Robert Ford, University of Manchester, UK.

 

Selected Publications

Journal Articles

Rosenberg MF, O'Ryan LP, Hughes G, et al., 2011, The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), Journal of Biological Chemistry, Vol:286, ISSN:0021-9258, Pages:42647-42654

More Publications