Summary
Mark Rosenberg is a Research Fellow in Computational and Systems Medicine, Department of Surgery and Cancer.
Research Interests:
Structural biology of challenging membrane proteins.
- Optimizing expression systems for the generation of membrane proteins.
- Crystallising membrane proteins of medical interest for 3-D structure determination for the purposes of drug design.
- Crystallization of membrane proteins related to cancer therapy and cystic fibrosis.
- Design of new methodology for the production of high-quality two-dimensional crystals for cryo-electron microscopy.
FELLOWSHIPS
EMBO Travel Fellowship to the Max Plank Institute, Frankfurt, Germany.
Royal Society Travel Fellowship to the University of Queens, Kingston, Ontario, Canada.
AWARDS
British Council Award to conduct collaboration at the Pasteur Institute (Paris).
RESEARCH
Dr Rosenberg has determined the first three-dimensional structures of P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1) and the cystic fibrosis transmembrane conductance regulator (CFTR).
COLABORATORS
Professor John Riordan, University of North Carolina, USA.
Dr Qincheng Mao, Washington University, USA.
Professor Robert Ford, University of Manchester, UK.
Selected Publications
Journal Articles
Rosenberg MF, O'Ryan LP, Hughes G, et al., 2011, The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), Journal of Biological Chemistry, Vol:286, ISSN:0021-9258, Pages:42647-42654