Imperial College London


Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Research Fellow







Sir Alexander Fleming BuildingSouth Kensington Campus





Mark Rosenberg is a Research Fellow in Computational and Systems Medicine, Department of Surgery and Cancer.


Research Interests:

Structural biology of challenging membrane proteins.

  • Optimizing expression systems for the generation of membrane proteins.
  • Crystallising membrane proteins of medical interest for 3-D structure determination for the purposes of drug design.
  • Crystallization of membrane proteins related to cancer therapy and cystic fibrosis.
  • Design of new methodology for the production of high-quality two-dimensional crystals for cryo-electron microscopy.




EMBO Travel Fellowship to the Max Plank Institute, Frankfurt, Germany.

Royal Society Travel Fellowship to the University of Queens, Kingston, Ontario, Canada.


British Council Award to conduct collaboration at the Pasteur Institute (Paris).


Dr Rosenberg has determined the first three-dimensional structures of P-glycoprotein (P-gp), multidrug resistance protein 1 (MRP1) and the cystic fibrosis transmembrane conductance regulator (CFTR).


Professor John Riordan, University of North Carolina, USA.

Dr Qincheng Mao, Washington University, USA.

Professor Robert Ford, University of Manchester, UK.


Selected Publications

Journal Articles

Rosenberg MF, O'Ryan LP, Hughes G, et al., 2011, The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), Journal of Biological Chemistry, Vol:286, ISSN:0021-9258, Pages:42647-42654

More Publications