Publications
34 results found
Segaran E, Wandrag L, Stotz M, et al., 2016, Does body mass index impact on muscle wasting and recovery following critical illness? A pilot feasibility observational study, Journal of Human Nutrition and Dietetics, Vol: 30, Pages: 227-235, ISSN: 1365-277X
BACKGROUND: Critical illness is associated with muscle loss, weakness and poor recovery. The impact that illness and the ensuing metabolic response has on obese patients is not known. Objectives were to test if obese patients lose less muscle depth compared to non-obese patients; if a reduction in muscle depth was associated with reduced strength and recovery; and to assess the feasibility of these methods with a range of body mass index's (BMI). METHODS: A prospective observational pilot study of muscle depth in critically ill patients categorised by BMI was performed. Muscle depth changes were assessed by ultrasound on study days 1, 3, 5, 7, 12 and 14. Strength was measured via handgrip dynamometry and Medical Research Council (MRC) sum score on waking and at discharge from the intensive care unit. Level of dependency was measured with the Barthel index. RESULTS: 44 critically ill patients; 17 had normal BMI, 10 were overweight and 17 were obese. The three groups did not differ in baseline characteristics, except obese patients had significantly greater initial muscle depth. Muscle depth loss was similar between the BMI groups at each of the time points. Handgrip and MRC sum score were only possible in a small number of patients because of reduced alertness and weakness. Majority were deemed fully dependent based on the Barthel index. CONCLUSIONS: Obese patients lost muscle depth in a comparable manner to non-obese patients, suggesting that BMI may not prevent muscle depth loss. It was not possible to determine the effect on strength because the clinical condition of patients precluded reliable measurements.
Hickson M, Frost G, Dhillo WS, et al., 2016, Increased Peptide YY blood concentrations, not decreased acyl-ghrelin, are associated with reduced hunger and food intake in healthy older women: preliminary evidence, Appetite, Vol: 105, Pages: 320-327, ISSN: 1095-8304
With ageing there is frequently a loss of appetite, termed anorexia of ageing, which can result in under-nutrition. We do not know how appetite control alters with ageing. The objective of this study was to investigate whether differences in the release of, and response to, gastrointestinal appetite hormones is altered in young compared to old healthy volunteers. We hypothesised that an increase in PYY and GLP-1 or a decrease ghrelin may result in a decreased appetite. A comparative experimental design, using a cross-sectional sample of ages from a healthy population, matched for sex and BMI was used. The study compared total ghrelin, acyl-ghrelin, PYY, GLP-1 and subjective appetite responses to ingestion of a standardised 2781kj (660kcal) test meal. 31 female volunteers aged between 21-92yrs took part. Multiple linear regression showed that both age and sex had an independent effect on energy intake. Subjective appetite scores showed that hunger, pleasantness to eat, and prospective food intake were significantly lower in the older age groups. PYY incremental area under the curve (IAUC) was greater in the oldest old compared to younger ages f(3,27)=2.9, p=0.05. No differences in GLP-1, ghrelin or acyl-ghrelin were observed in the older compared to younger age groups. Our data suggest that there may be increases in postprandial PYY(3-36) levels in female octogenarians, potentially resulting in reduced appetite. There does not appear to be any change in ghrelin or acyl-ghrelin concentrations with ageing.
Wandrag L, Brett SJ, Frost G, et al., 2015, Impact of supplementation with amino acids or their metabolites on muscle wasting in patients with critical illness or other muscle wasting illness: a systematic review, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 28, Pages: 313-330, ISSN: 0952-3871
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- Citations: 36
Moss C, Dhillo WS, Frost G, et al., 2012, Gastrointestinal hormones: the regulation of appetite and the anorexia of ageing, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 25, Pages: 3-15, ISSN: 0952-3871
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- Citations: 57
Hickson M, Connolly A, Whelan K, 2011, Impact of protected mealtimes on ward mealtime environment, patient experience and nutrient intake in hospitalised patients, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 24, Pages: 370-374, ISSN: 0952-3871
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- Citations: 62
Wandrag L, Gordon F, O'Flynn J, et al., 2011, Identifying the factors that influence energy deficit in the adult intensive care unit: a mixed linear model analysis, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 24, Pages: 215-222, ISSN: 0952-3871
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- Citations: 8
Hickson M, 2011, Probiotics in the prevention of antibiotic-associated diarrhoea and Clostridium difficile infection., Therap Adv Gastroenterol, Vol: 4, Pages: 185-197
Diarrhoea, as a common side effect of antibiotics, increases treatment costs and length of stay in acute healthcare facilities. One potential strategy to prevent this side effect is the concurrent use of probiotic bacteria or yeast. This review discusses the evidence for the efficacy of probiotics in the prevention of antibiotic-associated diarrhoea and Clostridium difficile infection; the potential mechanisms by which probiotics may work; their safety; what future research is required; and recommendations for use in clinical practice.
Brown EA, Johansson L, Farrington K, et al., 2010, Broadening Options for Long-term Dialysis in the Elderly (BOLDE): differences in quality of life on peritoneal dialysis compared to haemodialysis for older patients, Nephrology Dialysis Transplantation, Vol: 25, Pages: 3755-3763, ISSN: 1460-2385
Background. Health-related quality of life (QOL) is an importantoutcome for older people who are often on dialysisfor life. Little is, however, known about differences in QOLon haemodialysis (HD) and peritoneal dialysis (PD) in olderage groups. Randomising patients to either modality toassess outcomes is not feasible.Methods. In this cross-sectional, multi-centred study weconducted QOL assessments (Short Form-12 Mental andPhysical Component Summary scales, Hospital Anxietyand Depression Scale and Illness Intrusiveness RatingsScale) in 140 people (aged 65 years or older) on PDand HD.Results. The groups were similar in age, gender, time ondialysis, ethnicity, Index of Deprivation (based on postcode),dialysis adequacy, cognitive function (Mini-MentalState Exam and Trail-Making Test B), nutritional status(Subjective Global Assessment) and social networks.There was a higher comorbidity score in the HD group.Regression analyses were undertaken to ascertain whichvariables significantly influence each QOL assessment.All were influenced by symptom count highlighting thatthe patient’s perception of their symptoms is a criticaldeterminant of their mental and physical well being.Modality was found to be an independent predictorof illness intrusion with greater intrusion felt in thoseon HD.Conclusions. Overall, in two closely matched demographicgroups of older dialysis patients, QOL was similar, if notbetter, in those on PD. This study strongly supports offeringPD to all suitable older people.
Hickson M, 2010, Quality improvement and research in advancing dietetic and clinical nutrition, Advancing Dietetics and Clinical Nutrition, Editors: Barker, Payne, Publisher: Churchill Livingstone, Pages: xi-xiii, ISBN: 9780443067860
Tammam JD, Gardner L, Hickson M, 2009, Validity, reliability and acceptability of the Imperial Nutritional Screening System (INSYST): a tool that does not require the body mass index, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 22, Pages: 536-544, ISSN: 0952-3871
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- Citations: 20
Philippou E, Bovill-Taylor C, Rajkumar C, et al., 2009, Preliminary report: the effect of a 6-month dietary glycemic index manipulation in addition to healthy eating advice and weight loss on arterial compliance and 24-hour ambulatory blood pressure in men: a pilot study, METABOLISM-CLINICAL AND EXPERIMENTAL, Vol: 58, Pages: 1703-1708, ISSN: 0026-0495
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- Citations: 27
Philippou E, Neary NM, Chaudhri O, et al., 2009, The Effect of Dietary Glycemic Index on Weight Maintenance in Overweight Subjects: A Pilot Study, OBESITY, Vol: 17, Pages: 396-401, ISSN: 1930-7381
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- Citations: 18
Hickson M, Macqueen C, Frost G, 2009, Evaluation of attendance and weight loss in an intensive weight management clinic compared to standard dietetic care, Journal of Human Nutrition and Dietetics, Vol: 1, Pages: 72-76, ISSN: 1365-277X
BACKGROUND: With increasing rates of obesity, the effectiveness of weight reduction programmes come under increasing scrutiny. This nonrandomized study aimed to review the effectiveness of two weight loss clinics in terms of percent and rate of weight loss, and attendance. METHODS: Data were collected on consecutive obese patients, attending either an intensive weight management clinic (IWMC) or a general dietetic outpatient clinic. The IWMC had a structured approach with six once-a-month appointments, a signed agreement to attend, an initial screening of readiness to change and consistent advice from one dietitian. The general clinic was less structured, had more ad hoc follow up and did not guarantee one dietitian. RESULTS: Seventy percent of patients referred were female [mean (SD) age 48 (14.2) years]. Thirty-three percent (103/313) of all patients referred did not book an appointment. Of those attending with a body mass index > or = 32 kg m(-2), 55% were seen in the general and 45% in the intensive clinic, but only 19% and 53%, respectively, completed the programmes. The total amount and rate of weight loss did not differ significantly between clinics. However, analysis using the last recorded weight revealed a median weight reduction of 1.8% (interquartile range = -5.6-0) at the median rate of -0.4 kg month(-1) (-1-0) in the intensive clinic, compared to no overall weight loss in the general clinic (P < or = 0.001). CONCLUSIONS: A more structured approach and initial screening of readiness to change is likely to achieve better weight loss results and therefore will comprise a better use of dietetic time than including obese patients in general clinics.
Wright L, Cotter D, Hickson M, 2008, The effectiveness of targeted feeding assistance to improve the nutritional intake of elderly dysphagic patients in hospital, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 21, Pages: 555-562, ISSN: 0952-3871
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- Citations: 52
Hickson M, 2008, Research Handbook for Health Care Professionals, Publisher: Blackwell Pub, ISBN: 9781405177375
The Research Handbook for Health Care Professionals is the essential guide to the entire research process for students and practitioners alike.
Milton JE, Briche B, Brown IJ, et al., 2007, Relationship of glycaemic index with cardiovascular risk factors: analysis of the National Diet and Nutrition Survey for people aged 65 and older, PUBLIC HEALTH NUTRITION, Vol: 10, Pages: 1321-1335, ISSN: 1368-9800
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- Citations: 15
Hickson M, Fearnley L, Thomas J, et al., 2007, Does a new steam meal catering system meet patient requirements in hospital?, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 20, Pages: 476-485, ISSN: 0952-3871
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- Citations: 14
Aloysius A, Hickson M, 2007, Evaluation of paladai cup feeding in breast-fed preterm infants compared with bottle feeding, EARLY HUMAN DEVELOPMENT, Vol: 83, Pages: 619-621, ISSN: 0378-3782
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- Citations: 17
Hickson M, 2007, Evaluation of the 'Steamplicity' food service system., J Hum Nutr Diet, Vol: 20, Pages: 355-356, ISSN: 0952-3871
Hickson M, D'Souza AL, Muthu N, et al., 2007, Use of probiotic <i>Lactobacillus</i> preparation to prevent diarrhoea associated with antibiotics:: randomised double blind placebo controlled trial, BMJ-BRITISH MEDICAL JOURNAL, Vol: 335, Pages: 80-83, ISSN: 1756-1833
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- Citations: 374
Nematy M, Hickson M, Brynes AE, et al., 2006, Vulnerable patients with a fractured neck of femur: nutritional status and support in hospital, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 19, Pages: 209-218, ISSN: 0952-3871
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- Citations: 34
Wright L, Hickson M, Frost G, 2006, Eating together is important: using a dining room in an acute elderly medical ward increases energy intake, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 19, Pages: 23-26, ISSN: 0952-3871
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- Citations: 66
O'Flynn J, Peake H, Hickson M, et al., 2005, The prevalence of malnutrition in hospitals can be reduced: Results from three consecutive cross-sectional studies, CLINICAL NUTRITION, Vol: 24, Pages: 1078-1088, ISSN: 0261-5614
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- Citations: 98
Wright L, Cotter D, Hickson M, et al., 2005, Comparison of energy and protein intakes of older people consuming a texture modified diet with a normal hospital diet, JOURNAL OF HUMAN NUTRITION AND DIETETICS, Vol: 18, Pages: 213-219, ISSN: 0952-3871
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- Citations: 147
Hickson M, 2005, Malnutrition in elderly hospital patients:Identifying the causes., Hospital Healthcare Europe
Wright L, Hickson M, FrostG, 2005, Eating together is important: using a dining room increases energy intake, British Dietetic Association National Conference
Hickson M, Frost G, 2004, An investigation into the relationships between quality of life, nutritional status and physical function, CLINICAL NUTRITION, Vol: 23, Pages: 213-221, ISSN: 0261-5614
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- Citations: 50
Edington J, Barnes R, Bryan F, et al., 2004, A prospective randomised controlled trial of nutritional supplementation in malnourished elderly in the community: clinical and health economic outcomes, CLINICAL NUTRITION, Vol: 23, Pages: 195-204, ISSN: 0261-5614
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- Citations: 98
Hickson M, Bulpitt C, Nunes M, et al., 2004, Does additional feeding support provided by health care assistants improve nutritional status and outcome in acutely ill older in-patients? - a randomised control trial, CLINICAL NUTRITION, Vol: 23, Pages: 69-77, ISSN: 0261-5614
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- Citations: 74
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