Imperial College London
Portrait Picture

Professor Matthew Fisher

Faculty of Medicine, School of Public Health

Professor of Fungal Disease Epidemiology
 
 
 
//

Contact

 

matthew.fisher Website

 
 
//

Location

 

1113Sir Michael Uren HubWhite City Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Farrer:2019:10.1128/mBio.02306-19,
author = {Farrer, RA and Chang, M and Davis, MJ and van, Dorp L and Yang, D-H and Shea, T and Sewell, TR and Meyer, W and Balloux, F and Edwards, HM and Chanda, D and Kwenda, G and Vanhove, M and Chang, YC and Cuomo, CA and Fisher, MC and Kwon-Chung, KJ},
doi = {10.1128/mBio.02306-19},
journal = {mBio},
pages = {1--19},
title = {A new lineage of cryptococcus gattii (VGV) discovered in the Central Zambezian Miombo Woodlands},
url = {http://dx.doi.org/10.1128/mBio.02306-19},
volume = {10},
year = {2019}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - We discovered a new lineage of the globally important fungal pathogen Cryptococcus gattii on the basis of analysis of six isolates collected from three locations spanning the Central Miombo Woodlands of Zambia, Africa. All isolates were from environments (middens and tree holes) that are associated with a small mammal, the African hyrax. Phylogenetic and population genetic analyses confirmed that these isolates form a distinct, deeply divergent lineage, which we name VGV. VGV comprises two subclades (A and B) that are capable of causing mild lung infection with negligible neurotropism in mice. Comparing the VGV genome to previously identified lineages of C. gattii revealed a unique suite of genes together with gene loss and inversion events. However, standard URA5 restriction fragment length polymorphism (RFLP) analysis could not distinguish between VGV and VGIV isolates. We therefore developed a new URA5 RFLP method that can reliably identify the newly described lineage. Our work highlights how sampling understudied ecological regions alongside genomic and functional characterization can broaden our understanding of the evolution and ecology of major global pathogens.
AU  - Farrer,RA
AU  - Chang,M
AU  - Davis,MJ
AU  - van,Dorp L
AU  - Yang,D-H
AU  - Shea,T
AU  - Sewell,TR
AU  - Meyer,W
AU  - Balloux,F
AU  - Edwards,HM
AU  - Chanda,D
AU  - Kwenda,G
AU  - Vanhove,M
AU  - Chang,YC
AU  - Cuomo,CA
AU  - Fisher,MC
AU  - Kwon-Chung,KJ
DO  - 10.1128/mBio.02306-19
EP  - 19
PY  - 2019///
SN  - 2150-7511
SP  - 1
TI  - A new lineage of cryptococcus gattii (VGV) discovered in the Central Zambezian Miombo Woodlands
T2  - mBio
UR  - http://dx.doi.org/10.1128/mBio.02306-19
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000500484800015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://mbio.asm.org/content/10/6/e02306-19
UR  - http://hdl.handle.net/10044/1/76263
VL  - 10
ER  -
Download