Imperial College London
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Professor Matthew Fisher

Faculty of Medicine, School of Public Health

Professor of Fungal Disease Epidemiology
 
 
 
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Contact

 

matthew.fisher Website

 
 
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Location

 

1113Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jervis:2021:10.1111/mec.15789,
author = {Jervis, P and Pintanel, P and Hopkins, K and Wierzbicki, C and Shelton, J and Skelly, E and Rosa, G and Almeida-Reinoso, D and Eugenia-Ordonez, M and Ron, S and Harrison, X and Fisher, M},
doi = {10.1111/mec.15789},
journal = {Molecular Ecology},
pages = {1322--1335},
title = {Postepizootic microbiome associations across communities of neotropical amphibians},
url = {http://dx.doi.org/10.1111/mec.15789},
volume = {30},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Microbiome–pathogen interactions are increasingly recognized as an important element of host immunity. While these hostlevel interactions will have consequences for community disease dynamics, the factors which influence host microbiomes at larger scales are poorly understood. We here describe landscapescale pathogen–microbiome associations within the context of postepizootic amphibian chytridiomycosis, a disease caused by the panzootic chytrid fungus Batrachochytrium dendrobatidis. We undertook a survey of Neotropical amphibians across altitudinal gradients in Ecuador ~30 years following the observed amphibian declines and collected skin swabsamples which were metabarcoded using both fungal (ITS2) and bacterial (r16S) amplicons. The data revealed marked variation in patterns of both B. dendrobatidis infection and microbiome structure that are associated with host life history. Stream breeding amphibians were most likely to be infected with B. dendrobatidis. This increased probability of infection was further associated with increased abundance and diversity of nonBatrachochytrium chytrid fungi in the skin and environmental microbiome. We also show that increased alpha diversity and the relative abundance of fungi are lower in the skin microbiome of adult stream amphibians compared to adult pondbreeding amphibians, an association not seen for bacteria. Finally, stream tadpoles exhibit lower proportions of predicted protective microbial taxa than pond tadpoles, suggesting reduced biotic resistance. Our analyses show that host breeding ecology strongly shapes pathogen–microbiome associations at a landscape scale, a trait that may influence resilience in the face of emerging infectious diseases.
AU  - Jervis,P
AU  - Pintanel,P
AU  - Hopkins,K
AU  - Wierzbicki,C
AU  - Shelton,J
AU  - Skelly,E
AU  - Rosa,G
AU  - Almeida-Reinoso,D
AU  - Eugenia-Ordonez,M
AU  - Ron,S
AU  - Harrison,X
AU  - Fisher,M
DO  - 10.1111/mec.15789
EP  - 1335
PY  - 2021///
SN  - 0962-1083
SP  - 1322
TI  - Postepizootic microbiome associations across communities of neotropical amphibians
T2  - Molecular Ecology
UR  - http://dx.doi.org/10.1111/mec.15789
UR  - https://onlinelibrary.wiley.com/doi/10.1111/mec.15789
UR  - http://hdl.handle.net/10044/1/86359
VL  - 30
ER  -
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