Imperial College London
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Professor Matthew Fisher

Faculty of Medicine, School of Public Health

Professor of Fungal Disease Epidemiology
 
 
 
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Contact

 

matthew.fisher Website

 
 
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Location

 

1113Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fernandez-Loras:2017:10.1007/s10344-017-1161-y,
author = {Fernandez-Loras, A and Fernandez-Beaskoetxea, S and Arriero, E and Fisher, MC and Bosch, J},
doi = {10.1007/s10344-017-1161-y},
journal = {EUROPEAN JOURNAL OF WILDLIFE RESEARCH},
title = {Early exposure to Batrachochytrium dendrobatidis causes profound immunosuppression in amphibians},
url = {http://dx.doi.org/10.1007/s10344-017-1161-y},
volume = {63},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Fungal pathogens have evolved a broad suite of strategies aiming at evading the host immune response. Amphibians are globally infected by the panzootic chytrid fungus Batrachochytrium dendrobatidis (Bd) and, while robust innate immune defences have been characterised, there is little evidence for the existence of effective adaptive immunity. We determine the immune response of the common midwife toad following challenge by Bd as larvae. Immune function was described for both the cell-mediated and antibody-mediated immune responses following infectious challenge as larval amphibians. While there were no significant differences in the ratio of neutrophils/lymphocytes between infected and uninfected individuals, early exposure of tadpoles to Bd significantly dampened the levels of circulating immunoglobulins (IgM and IgY) in the serum of juveniles after metamorphosis. Our results show that Bd immunosuppresses amphibians when infection occurs as larvae with potentially broad effects on the remodelling of immunity during metamorphosis.
AU  - Fernandez-Loras,A
AU  - Fernandez-Beaskoetxea,S
AU  - Arriero,E
AU  - Fisher,MC
AU  - Bosch,J
DO  - 10.1007/s10344-017-1161-y
PY  - 2017///
SN  - 1612-4642
TI  - Early exposure to Batrachochytrium dendrobatidis causes profound immunosuppression in amphibians
T2  - EUROPEAN JOURNAL OF WILDLIFE RESEARCH
UR  - http://dx.doi.org/10.1007/s10344-017-1161-y
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000418192400012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/56719
VL  - 63
ER  -
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