Imperial College London

Dr Matthew R. Lewis

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Senior Research Officer
 
 
 
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Contact

 

matthew.lewis

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

As head of the section of Bioanalytical Chemistry, I oversee a talented and diverse team of experts responsible for the development and application of novel analytical methodology for global profiling and targeted analysis of small molecules, peptides, lipids and proteins. Our principal application space includes human biofluids and tissue extracts as well as the animal models and cell cultures needed to explore disease mechanisms in greater depth. Our favoured technology platforms include nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC-MS) and LC-tandem mass spectrometry (LC-MS/MS). We are most active in the areas of:

  • Analytical method development
  • Technology development and refinement
  • Data extraction and pre-processing workflows
  • Data quality control and monitoring
  • Metabolite assignment and identification including structure elucidation

Together we work closely with clinicians, epidemiologists, and basic science researchers at Imperial to provide innovative and reliable bioanalytical solutions for metabolomics, lipidomics, and proteomics.

As the Chief Operations Officer for the National Phenome Centre (NPC), I am responsible for operational management and delivery of a wide portfolio of research collaborations. Within the NPC, our focus is split between meeting the needs of high precision analysis demanded by large sample cohorts from molecular epidemiology studies, and those of studies involving smaller clinically derived cohorts analysed using both established and developing technologies. 

Publications

Journals

Correia GDS, Takis PG, Sands CJ, et al., 2022, 1H NMR Signals from urine excreted protein are a source of bias in probabilistic quotient normalization, Analytical Chemistry, ISSN:0003-2700

Inglese P, Huang HX, Wu V, et al., 2022, Mass recalibration for desorption electrospray ionization mass spectrometry imaging using endogenous reference ions, Bmc Bioinformatics, Vol:23, ISSN:1471-2105, Pages:1-17

Climaco Pinto R, Karaman I, Lewis MR, et al., 2022, Finding correspondence between metabolomic features in untargeted liquid chromatography-mass spectrometry metabolomics datasets., Analytical Chemistry, Vol:94, ISSN:0003-2700, Pages:5493-5503

Lippa KA, Aristizabal-Henao JJ, Beger RD, et al., 2022, Reference materials for MS-based untargeted metabolomics and lipidomics: a review by the metabolomics quality assurance and quality control consortium (mQACC), Metabolomics, Vol:18, ISSN:1573-3882

Sliz E, Shin J, Ahmad S, et al., 2022, Circulating Metabolome and White Matter Hyperintensities in Women and Men, Circulation, Vol:145, ISSN:0009-7322, Pages:1040-1052

More Publications