Imperial College London

Dr Matthew R. Lewis

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Director of Metabolic Profiling - COO NPC
 
 
 
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Contact

 

matthew.lewis

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

As head of the section of Bioanalytical Chemistry, I oversee a talented and diverse team of experts responsible for the development and application of novel analytical methodology for global profiling and targeted analysis of small molecules, peptides, lipids and proteins. Our principal application space includes human biofluids and tissue extracts as well as the animal models and cell cultures needed to explore disease mechanisms in greater depth. Our favoured technology platforms include nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC-MS) and LC-tandem mass spectrometry (LC-MS/MS). We are most active in the areas of:

  • Analytical method development
  • Technology development and refinement
  • Data extraction and pre-processing workflows
  • Data quality control and monitoring
  • Metabolite assignment and identification including structure elucidation

Together we work closely with clinicians, epidemiologists, and basic science researchers at Imperial to provide innovative and reliable bioanalytical solutions for metabolomics, lipidomics, and proteomics.

As the Chief Operations Officer for the National Phenome Centre (NPC), I am responsible for operational management and delivery of a wide portfolio of research collaborations. Within the NPC, our focus is split between meeting the needs of high precision analysis demanded by large sample cohorts from molecular epidemiology studies, and those of studies involving smaller clinically derived cohorts analysed using both established and developing technologies. 

Publications

Journals

Jones B, Sands C, Alexiadou K, et al., 2021, The metabolomic effects of tripeptide gut hormone infusion compared to Roux-en-Y gastric bypass and caloric restriction, Journal of Clinical Endocrinology and Metabolism, ISSN:0021-972X

Ferreira MR, Sands CJ, Li JV, et al., 2021, Impact of Pelvic Radiation Therapy for Prostate Cancer on Global Metabolic Profiles and Microbiota-Driven Gastrointestinal Late Side Effects: A Longitudinal Observational Study., Int J Radiat Oncol Biol Phys

Blaise BJ, Correia GDS, Haggart GA, et al., 2021, Statistical analysis in metabolic phenotyping, Nature Protocols, Vol:16, ISSN:1754-2189, Pages:4299-4326

Li J, Li JV, Ashrafian H, et al., 2021, Roux-en-Y Gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype, Microbiome, Vol:9, ISSN:2049-2618

Conference

Sharma R, Lu H, George J, et al., 2021, Discriminatory changes in circulating lipid and small molecule metabolites in patients with MAFLD associated hepatocellular cancer, ELSEVIER, Pages:S490-S490, ISSN:0168-8278

More Publications