Imperial College London

Dr Matthew R. Lewis

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Senior Research Officer
 
 
 
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Contact

 

matthew.lewis

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

As head of the section of Bioanalytical Chemistry, I oversee a talented and diverse team of experts responsible for the development and application of novel analytical methodology for global profiling and targeted analysis of small molecules, peptides, lipids and proteins. Our principal application space includes human biofluids and tissue extracts as well as the animal models and cell cultures needed to explore disease mechanisms in greater depth. Our favoured technology platforms include nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC-MS) and LC-tandem mass spectrometry (LC-MS/MS). We are most active in the areas of:

  • Analytical method development
  • Technology development and refinement
  • Data extraction and pre-processing workflows
  • Data quality control and monitoring
  • Metabolite assignment and identification including structure elucidation

Together we work closely with clinicians, epidemiologists, and basic science researchers at Imperial to provide innovative and reliable bioanalytical solutions for metabolomics, lipidomics, and proteomics.

As the Chief Operations Officer for the National Phenome Centre (NPC), I am responsible for operational management and delivery of a wide portfolio of research collaborations. Within the NPC, our focus is split between meeting the needs of high precision analysis demanded by large sample cohorts from molecular epidemiology studies, and those of studies involving smaller clinically derived cohorts analysed using both established and developing technologies. 

Publications

Journals

Valdivia-Garcia MA, Chappell KE, Camuzeaux S, et al., 2022, Improved quantitation of short-chain carboxylic acids in human biofluids using 3-nitrophenylhydrazine derivatization and liquid chromatography with tandem mass spectrometry (LC-MS/MS), Journal of Pharmaceutical and Biomedical Analysis, Vol:221, ISSN:0731-7085

Kowalka AM, Alexiadou K, Cuenco J, et al., 2022, The post-prandial secretion of Peptide YY<sub>1-36</sub> and <sub>3-36</sub> in obesity is differentially increased after gastric bypass versus sleeve gastrectomy., Clin Endocrinol (oxf)

Dehghan A, Pinto RC, Karaman I, et al., 2022, Metabolome-wide association study on ABCA7 indicates a role of ceramide metabolism in Alzheimer's disease., Proc Natl Acad Sci U S A, Vol:119

Mullish BH, Martinez Gili L, Chekmeneva E, et al., 2022, Assessing the clinical value of faecal bile acid profiling to predict recurrence in primary Clostridioides difficile infection, Alimentary Pharmacology and Therapeutics, ISSN:0269-2813

Takis PG, Vuckovic I, Tan T, et al., 2022, NMRpQuant: an automated software for large scale urinary total protein quantification by one-dimensional 1H NMR profiles, Bioinformatics, Vol:38, ISSN:1367-4803, Pages:4437-4439

More Publications