Imperial College London

Dr Matthew R. Lewis

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Director of Metabolic Profiling - COO NPC
 
 
 
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Contact

 

matthew.lewis

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

As head of the section of Bioanalytical Chemistry, I oversee a talented and diverse team of experts responsible for the development and application of novel analytical methodology for global profiling and targeted analysis of small molecules, peptides, and beyond. Our principal application space is human biofluids and tissue extracts as well as the animal models and cell cultures needed to explore disease mechanisms in greater depth. Our favoured technology platforms include nuclear magnetic resonance (NMR), liquid chromatography mass spectrometry (LC-MS) and LC-tandem mass spectrometry (LC-MS/MS). We are most active in the areas of:

  • Analytical method development
  • Technology development and refinement
  • Data extraction and pre-processing workflows
  • Data quality control and monitoring
  • Metabolite assignment and identification including structure elucidation

Together we work closely with clinicians, epidemiologists, and basic science researchers at Imperial to provide innovative and reliable solutions for metabolomics, lipidomics, and soon for proteomics.

As the Chief Operations Officer for the National Phenome Centre (NPC), I am responsible for operational management and delivery of a wide portfolio of research collaborations. Within the NPC, our focus is split between meeting the needs of high precision analysis demanded by large sample cohorts from molecular epidemiology studies, and those of studies involving smaller clinically derived cohorts analysed using both established and developing technologies.

Publications

Journals

Whiley L, Chappell KE, D'Hondt E, et al., 2021, Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease., Alzheimers Res Ther, Vol:13

Gadgil MD, Kanaya AM, Sands C, et al., 2020, Circulating metabolites and lipids are associated with glycaemic measures in South Asians, Diabetic Medicine, ISSN:0742-3071

Kurbatova N, Garg M, Whiley L, et al., 2020, Urinary metabolic phenotyping for Alzheimer's disease., Sci Rep, Vol:10

Evans AM, O'Donovan C, Playdon M, et al., 2020, Dissemination and analysis of the quality assurance (QA) and quality control (QC) practices of LC-MS based untargeted metabolomics practitioners, Metabolomics, Vol:16, ISSN:1573-3882

Conference

Chen Q, Alexiadou K, Jones B, et al., 2020, Low-calorie intake: a key mechanism contributing to the metabolic impacts of Roux-en-Y gastric bypass surgery, 56th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SPRINGER, Pages:S263-S264, ISSN:0012-186X

More Publications