Imperial College London
Alternate

Dr Matthew R. Lewis

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Research Officer
 
 
 
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Contact

 

matthew.lewis

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gadgil:2022:jn/nxac191,
author = {Gadgil, MD and Kanaya, AM and Sands, C and Chekmeneva, E and Lewis, MR and Kandula, NR and Herrington, DM},
doi = {jn/nxac191},
journal = {J Nutr},
pages = {2358--2366},
title = {Diet Patterns Are Associated with Circulating Metabolites and Lipid Profiles of South Asians in the United States.},
url = {http://dx.doi.org/10.1093/jn/nxac191},
volume = {152},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: South Asians are at higher risk for cardiometabolic disease than many other racial/ethnic minority groups. Diet patterns in US South Asians have unique components associated with cardiometabolic disease. OBJECTIVES: We aimed to characterize the metabolites associated with 3 representative diet patterns. METHODS: We included 722 participants in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort study aged 40-84 y without known cardiovascular disease. Fasting serum specimens and diet and demographic questionnaires were collected at baseline and diet patterns previously generated through principal components analysis. LC-MS-based untargeted metabolomic and lipidomic analysis was conducted with targeted integration of known metabolite and lipid signals. Linear regression models of diet pattern factor score and log-transformed metabolites adjusted for age, sex, caloric intake, and BMI and adjusted for multiple comparisons were performed, followed by elastic net linear regression of significant metabolites. RESULTS: There were 443 metabolites of known identity extracted from the profiling data. The "animal protein" diet pattern was associated with 61 metabolites and lipids, including glycerophospholipids phosphatidylethanolamine PE(O-16:1/20:4) and/or PE(P-16:0/20:4) (β: 0.13; 95% CI: 0.11, 0.14) and N-acyl phosphatidylethanolamines (NAPEs) NAPE(O-18:1/20:4/18:0) and/or NAPE(P-18:0/20:4/18:0) (β: 0.13; 95% CI: 0.11, 0.14), lysophosphatidylinositol (LPI) (22:6/0:0) (β: 0.14; 95% CI: 0.12, 0.17), and fatty acid (FA) (22:6) (β: 0.15; 95% CI: 0.13, 0.17). The "fried snacks, sweets, high-fat dairy" pattern was associated with 12 lipids, including PC(16:0/22:6) (β: -0.08; 95% CI: -0.09, -0.06) and FA (22:6) (β: 0.14; 95% CI: -0.17, -0.10). The "fruits, vegetables, nuts, and legumes" pattern was associated with 5 metabolites including proline betaine (β: 0.17; 95% CI: 0.0
AU  - Gadgil,MD
AU  - Kanaya,AM
AU  - Sands,C
AU  - Chekmeneva,E
AU  - Lewis,MR
AU  - Kandula,NR
AU  - Herrington,DM
DO  - jn/nxac191
EP  - 2366
PY  - 2022///
SP  - 2358
TI  - Diet Patterns Are Associated with Circulating Metabolites and Lipid Profiles of South Asians in the United States.
T2  - J Nutr
UR  - http://dx.doi.org/10.1093/jn/nxac191
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36774102
VL  - 152
ER  -
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