Imperial College London

ProfessorMatthewPickering

Faculty of MedicineDepartment of Immunology and Inflammation

Professor of Rheumatology
 
 
 
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Contact

 

matthew.pickering Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Laskowski:2020:10.1172/JCI135105,
author = {Laskowski, J and Renner, B and Pickering, MC and Serkova, NJ and Smith-Jones, PM and Clambey, ET and Nemenoff, RA and Thurman, JM},
doi = {10.1172/JCI135105},
journal = {J Clin Invest},
pages = {4039--4054},
title = {Complement factor H-deficient mice develop spontaneous hepatic tumors.},
url = {http://dx.doi.org/10.1172/JCI135105},
volume = {130},
year = {2020}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Hepatocellular carcinoma (HCC) is difficult to detect, carries a poor prognosis, and is one of few cancers with an increasing yearly incidence. Molecular defects in complement factor H (CFH), a critical regulatory protein of the complement alternative pathway (AP), are typically associated with inflammatory diseases of the eye and kidney. Little is known regarding the role of CFH in controlling complement activation within the liver. While studying aging CFH-deficient (fH-/-) mice, we observed spontaneous hepatic tumor formation in more than 50% of aged fH-/- males. Examination of fH-/- livers (3-24 months) for evidence of complement-mediated inflammation revealed widespread deposition of complement-activation fragments throughout the sinusoids, elevated transaminase levels, increased hepatic CD8+ and F4/80+ cells, overexpression of hepatic mRNA associated with inflammatory signaling pathways, steatosis, and increased collagen deposition. Immunostaining of human HCC biopsies revealed extensive deposition of complement fragments within the tumors. Investigating the Cancer Genome Atlas also revealed that increased CFH mRNA expression is associated with improved survival in patients with HCC, whereas mutations are associated with worse survival. These results indicate that CFH is critical for controlling complement activation in the liver, and in its absence, AP activation leads to chronic inflammation and promotes hepatic carcinogenesis.
AU - Laskowski,J
AU - Renner,B
AU - Pickering,MC
AU - Serkova,NJ
AU - Smith-Jones,PM
AU - Clambey,ET
AU - Nemenoff,RA
AU - Thurman,JM
DO - 10.1172/JCI135105
EP - 4054
PY - 2020///
SP - 4039
TI - Complement factor H-deficient mice develop spontaneous hepatic tumors.
T2 - J Clin Invest
UR - http://dx.doi.org/10.1172/JCI135105
UR - https://www.ncbi.nlm.nih.gov/pubmed/32369457
VL - 130
ER -