Imperial College London
Alternate

ProfessorMatthewPickering

Faculty of Medicine, Department of Immunology and Inflammation

Centre Director, Professor of Rheumatology
 
 
 
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Contact

 

matthew.pickering Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Nayagam:2020:10.1111/ajt.15785,
author = {Nayagam, JS and McGrath, S and Montasser, M and Delaney, M and Cairns, TD and Marchbank, KJ and Sacks, SH and Cook, HT and Shah, S and Heaton, N and Pickering, MC and Suddle, A},
doi = {10.1111/ajt.15785},
journal = {American Journal of Transplantation},
pages = {2260--2263},
title = {Successful simultaneous liver-kidney transplantation for renal failure associated with hereditary complement C3 deficiency.},
url = {http://dx.doi.org/10.1111/ajt.15785},
volume = {20},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Hereditary complement C3 deficiency is associated with recurrent bacterial infections and proliferative glomerulonephritis. We describe a case of an adult with complete deficiency of complement C3 due to homozygous mutations in C3 gene: c.1811delT (Val604Glyfs2), recurrent bacterial infections, crescentic glomerulonephritis and end-stage renal failure. Following isolated kidney transplantation he would remain C3 deficient with a similar, or increased, risk of infections and glomerulonephritis. As C3 is predominantly synthesised in the liver, with a small proportion of C3 monocyte-derived and kidney-derived, he proceeded to simultaneous liver-kidney transplantation. The procedure has been successful with restoration of his circulating C3 levels, normal liver and kidney function at 26 months of follow up. Simultaneous liver-kidney transplant is a viable option to be considered in this rare setting.
AU  - Nayagam,JS
AU  - McGrath,S
AU  - Montasser,M
AU  - Delaney,M
AU  - Cairns,TD
AU  - Marchbank,KJ
AU  - Sacks,SH
AU  - Cook,HT
AU  - Shah,S
AU  - Heaton,N
AU  - Pickering,MC
AU  - Suddle,A
DO  - 10.1111/ajt.15785
EP  - 2263
PY  - 2020///
SN  - 1600-6135
SP  - 2260
TI  - Successful simultaneous liver-kidney transplantation for renal failure associated with hereditary complement C3 deficiency.
T2  - American Journal of Transplantation
UR  - http://dx.doi.org/10.1111/ajt.15785
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31970896
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.15785
UR  - http://hdl.handle.net/10044/1/76467
VL  - 20
ER  -
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