Imperial College London
Alternate

ProfessorMatthewPickering

Faculty of Medicine, Department of Immunology and Inflammation

Centre Director, Professor of Rheumatology
 
 
 
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Contact

 

matthew.pickering Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Laskowski:2016:10.1016/j.kint.2016.02.036,
author = {Laskowski, J and Renner, B and Le, Quintrec M and Panzer, S and Hannan, JP and Ljubanovic, D and Ruseva, MM and Borza, DB and Antonioli, AH and Pickering, MC and Holers, VM and Thurman, JM},
doi = {10.1016/j.kint.2016.02.036},
journal = {Kidney International},
pages = {109--122},
title = {Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury},
url = {http://dx.doi.org/10.1016/j.kint.2016.02.036},
volume = {90},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mutations in the complement regulatory proteins are associated with several different diseases. Although these mutations cause dysregulated alternative pathway activation throughout the body, the kidneys are the most common site of injury. The susceptibility of the kidney to alternative pathway-mediated injury may be due to limited expression of complement regulatory proteins on several tissue surfaces within the kidney. To examine the roles of the complement regulatory proteins factor H and Crry in protecting distinct renal surfaces from alternative pathway mediated injury, we generated mice with targeted deletions of the genes for both proteins. Surprisingly, mice with combined genetic deletions of factor H and Crry developed significantly milder renal injury than mice deficient in only factor H. Deficiency of both factor H and Crry was associated with C3 deposition at multiple locations within the kidney, but glomerular C3 deposition was lower than that in factor H alone deficient mice. Thus, factor H and Crry are critical for regulating complement activation at distinct anatomic sites within the kidney. However, widespread activation of the alternative pathway reduces injury by depleting the pool of C3 available at any 1 location.
AU  - Laskowski,J
AU  - Renner,B
AU  - Le,Quintrec M
AU  - Panzer,S
AU  - Hannan,JP
AU  - Ljubanovic,D
AU  - Ruseva,MM
AU  - Borza,DB
AU  - Antonioli,AH
AU  - Pickering,MC
AU  - Holers,VM
AU  - Thurman,JM
DO  - 10.1016/j.kint.2016.02.036
EP  - 122
PY  - 2016///
SN  - 1523-1755
SP  - 109
TI  - Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury
T2  - Kidney International
UR  - http://dx.doi.org/10.1016/j.kint.2016.02.036
UR  - http://hdl.handle.net/10044/1/33438
VL  - 90
ER  -
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