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@article{Lomax-Browne:2017:10.1681/ASN.2016020184,
author = {Lomax-Browne, HJ and Visconti, A and Pusey, CD and Spector, TD and Pickering, MC and Falchi, M and Cook, HT},
doi = {10.1681/ASN.2016020184},
journal = {Journal of the American Society of Nephrology},
pages = {64--68},
title = {IgA1 glycosylation is heritable in healthy twins},
url = {http://dx.doi.org/10.1681/ASN.2016020184},
volume = {28},
year = {2017}
}

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TY  - JOUR
AB  - IgA Nephropathy (IgAN) is the most common form of primary glomerulonephritis and an important cause of kidney failure. Characteristically, IgAN patients have increased serum levels of under-galactosylated IgA1 (gd-IgA1). We assessed the degree to which serum gd-IgA1 levels are genetically determined in healthy individuals. Serum IgA and gd-IgA1 level were determined by ELISA in a sample of 148 healthy female twins including 27 monozygotic and 47 dizygotic pairs. Using the classical twin model, the heritability of serum gd-IgA1 and IgA levels were 80% (95% CI: 66-89%) and 46% (95% CI: 15-69%) respectively. These data indicate that serum gd-IgA1 levels are highly heritable. Elucidating the genetic basis of this heritability will be important in understanding the pathogenesis of IgAN.
AU  - Lomax-Browne,HJ
AU  - Visconti,A
AU  - Pusey,CD
AU  - Spector,TD
AU  - Pickering,MC
AU  - Falchi,M
AU  - Cook,HT
DO  - 10.1681/ASN.2016020184
EP  - 68
PY  - 2017///
SN  - 1533-3450
SP  - 64
TI  - IgA1 glycosylation is heritable in healthy twins
T2  - Journal of the American Society of Nephrology
UR  - http://dx.doi.org/10.1681/ASN.2016020184
UR  - https://jasn.asnjournals.org/content/28/1/64/
UR  - http://hdl.handle.net/10044/1/33245
VL  - 28
ER  -

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