Imperial College London
Alternate

ProfessorMatthewPickering

Faculty of Medicine, Department of Immunology and Inflammation

Centre Director, Professor of Rheumatology
 
 
 
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Contact

 

matthew.pickering Website

 
 
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Assistant

 

Miss Claudia Rocchi +44 (0)20 3313 2315

 
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Location

 

9N12Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stratigou:2017:rheumatology/kex078,
author = {Stratigou, V and Doyle and Carlucci, F and Stephens, L and Foschi, V and Castelli, M and Mckenna, N and Cook and Lightstone and Cairns, TD and Pickering, MC and Botto, M},
doi = {rheumatology/kex078},
journal = {Rheumatology},
pages = {1206--1216},
title = {Altered expression of signalling lymphocyte activation molecule (SLAM) receptors in T cells from lupus nephritis patients  - a potential biomarker of disease activity.},
url = {http://dx.doi.org/10.1093/rheumatology/kex078},
volume = {56},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objectives. The aim was to investigate whether the signalling lymphocyte activation molecule (SLAM) signalling pathways contribute to LN and whether SLAM receptors could be valuable biomarkers of disease activity.Methods. Peripheral blood mononuclear cells from 30National Research Ethics Service SLE patients with biopsy-proven LN were analysed by flow cytometry. Clinical measures of disease activity were assessed. The expression of the SLAM family receptors on T-cell subpopulations [CD4, CD8 and double negative (DN) T cells] was measured and compared between lupus patients with active renal disease and those in remission.Results. The frequency of CD8 T cells expressing SLAMF3, SLAMF5 and SLAMF7 was significantly lower in LN patients who were in remission. In contrast, these subsets were similar in patients with active renal disease and in healthy individuals. Patients with active nephritis had an increased percentage of circulating monocytes, consistent with a potential role played by these cells in glomerular inflammation. Changes in the frequency of DN T cells positive for SLAMF2, SLAMF4 and SLAMF7 were observed in lupus patients irrespective of the disease activity. We detected alterations in the cellular expression of the SLAM family receptors, but these changes were less obvious and did not reveal any specific pattern. The percentage of DN T cells expressing SLAMF6 could predict the clinical response to B-cell depletion in patients with LN.Conclusion. Our study demonstrates altered expression of the SLAM family receptors in SLE T lymphocytes. This is consistent with the importance of the SLAM-associated pathways in lupus pathogenesis.
AU  - Stratigou,V
AU  - Doyle
AU  - Carlucci,F
AU  - Stephens,L
AU  - Foschi,V
AU  - Castelli,M
AU  - Mckenna,N
AU  - Cook
AU  - Lightstone
AU  - Cairns,TD
AU  - Pickering,MC
AU  - Botto,M
DO  - rheumatology/kex078
EP  - 1216
PY  - 2017///
SN  - 1462-0332
SP  - 1206
TI  - Altered expression of signalling lymphocyte activation molecule (SLAM) receptors in T cells from lupus nephritis patients  - a potential biomarker of disease activity.
T2  - Rheumatology
UR  - http://dx.doi.org/10.1093/rheumatology/kex078
UR  - http://hdl.handle.net/10044/1/45520
VL  - 56
ER  -
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