Imperial College London
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DrMatthewWall

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Lecturer
 
 
 
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Contact

 

matthew.wall

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Bloomfield:2019:10.1016/j.pharmthera.2018.10.006,
author = {Bloomfield, MAP and Hindocha, C and Green, SF and Wall, MB and Lees, R and Petrilli, K and Costello, H and Ogunbiyi, MO and Bossong, MG and Freeman, TP},
doi = {10.1016/j.pharmthera.2018.10.006},
journal = {Pharmacology and Therapeutics},
pages = {132--161},
title = {The neuropsychopharmacology of cannabis: A review of human imaging studies},
url = {http://dx.doi.org/10.1016/j.pharmthera.2018.10.006},
volume = {195},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The laws governing cannabis are evolving worldwide and associated with changing patterns of use. The main psychoactive drug in cannabis is Δ9-tetrahydrocannabinol (THC), a partial agonist at the endocannabinoid CB1 receptor. Acutely, cannabis and THC produce a range of effects on several neurocognitive and pharmacological systems. These include effects on executive, emotional, reward and memory processing via direct interactions with the endocannabinoid system and indirect effects on the glutamatergic, GABAergic and dopaminergic systems. Cannabidiol, a non-intoxicating cannabinoid found in some forms of cannabis, may offset some of these acute effects. Heavy repeated cannabis use, particularly during adolescence, has been associated with adverse effects on these systems, which increase the risk of mental illnesses including addiction and psychosis. Here, we provide a comprehensive state of the art review on the acute and chronic neuropsychopharmacology of cannabis by synthesizing the available neuroimaging research in humans. We describe the effects of drug exposure during development, implications for understanding psychosis and cannabis use disorder, and methodological considerations. Greater understanding of the precise mechanisms underlying the effects of cannabis may also give rise to new treatment targets.
AU  - Bloomfield,MAP
AU  - Hindocha,C
AU  - Green,SF
AU  - Wall,MB
AU  - Lees,R
AU  - Petrilli,K
AU  - Costello,H
AU  - Ogunbiyi,MO
AU  - Bossong,MG
AU  - Freeman,TP
DO  - 10.1016/j.pharmthera.2018.10.006
EP  - 161
PY  - 2019///
SN  - 0163-7258
SP  - 132
TI  - The neuropsychopharmacology of cannabis: A review of human imaging studies
T2  - Pharmacology and Therapeutics
UR  - http://dx.doi.org/10.1016/j.pharmthera.2018.10.006
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30347211
UR  - http://hdl.handle.net/10044/1/66202
VL  - 195
ER  -
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