Imperial College London
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DrMatthewWall

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Lecturer
 
 
 
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Contact

 

matthew.wall

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Salem:2021:10.2337/dc20-2641,
author = {Salem, V and Demetriou, L and Behary, P and Alexiadou, K and Scholtz, S and Tharakan, G and Miras, A and Purkayastha, S and Ahmed, A and Bloom, S and Wall, M and Dhillo, W and Tan, T},
doi = {10.2337/dc20-2641},
journal = {Diabetes Care},
pages = {1842--1851},
title = {Weight loss by low calorie diet versus gastric bypass surgery in people with diabetes results in divergent brain activation patterns: an functional MRI study},
url = {http://dx.doi.org/10.2337/dc20-2641},
volume = {44},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: Weight loss achieved with very-low-calorie diets (VLCDs) can produce remission of type 2 diabetes (T2D), but weight regain very often occurs with reintroduction of higher calorie intakes. In contrast, bariatric surgery produces clinically significant and durable weight loss, with diabetes remission that translates into reductions in mortality. We hypothesized that in patients living with obesity and prediabetes/T2D, longitudinal changes in brain activity in response to food cues as measured using functional MRI would explain this difference.RESEARCH DESIGN AND METHODS: Sixteen participants underwent gastric bypass surgery, and 19 matched participants undertook a VLCD (meal replacement) for 4 weeks. Brain responses to food cues and resting-state functional connectivity were assessed with functional MRI pre- and postintervention and compared across groups.RESULTS: We show that Roux-en-Y gastric bypass surgery (RYGB) results in three divergent brain responses compared with VLCD-induced weight loss: 1) VLCD resulted in increased brain reward center food cue responsiveness, whereas in RYGB, this was reduced; 2) VLCD resulted in higher neural activation of cognitive control regions in response to food cues associated with exercising increased cognitive restraint over eating, whereas RYGB did not; and 3) a homeostatic appetitive system (centered on the hypothalamus) is better engaged following RYGB-induced weight loss than VLCD.CONCLUSIONS: Taken together, these findings point to divergent brain responses to different methods of weight loss in patients with diabetes, which may explain weight regain after a short-term VLCD in contrast to enduring weight loss after RYGB.
AU  - Salem,V
AU  - Demetriou,L
AU  - Behary,P
AU  - Alexiadou,K
AU  - Scholtz,S
AU  - Tharakan,G
AU  - Miras,A
AU  - Purkayastha,S
AU  - Ahmed,A
AU  - Bloom,S
AU  - Wall,M
AU  - Dhillo,W
AU  - Tan,T
DO  - 10.2337/dc20-2641
EP  - 1851
PY  - 2021///
SN  - 0149-5992
SP  - 1842
TI  - Weight loss by low calorie diet versus gastric bypass surgery in people with diabetes results in divergent brain activation patterns: an functional MRI study
T2  - Diabetes Care
UR  - http://dx.doi.org/10.2337/dc20-2641
UR  - https://care.diabetesjournals.org/content/44/8/1842
UR  - http://hdl.handle.net/10044/1/90292
VL  - 44
ER  -
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