Imperial College London
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DrMatthewWall

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Lecturer
 
 
 
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Contact

 

matthew.wall

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lawn:2023:10.1111/add.16154,
author = {Lawn, W and Trinci, K and Mokrysz, C and Borissova, A and Ofori, S and Petrilli, K and Bloomfield, M and Haniff, ZR and Hall, D and Fernandez-Vinson, N and Wang, S and Englund, A and Chesney, E and Wall, MB and Freeman, TP and Curran, HV},
doi = {10.1111/add.16154},
journal = {Addiction},
pages = {1282--1294},
title = {The acute effects of cannabis with and without cannabidiol in adults and adolescents: A randomised, double-blind, placebo-controlled, crossover experiment.},
url = {http://dx.doi.org/10.1111/add.16154},
volume = {118},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND AND AIMS: Long-term harms of cannabis may be exacerbated in adolescence, but little is known about the acute effects of cannabis in adolescents. We aimed to (i) compare the acute effects of cannabis in adolescent and adult cannabis users and (ii) determine if cannabidiol (CBD) acutely modulates the effects of delta-9-tetrahydocannabinol (THC). DESIGN: Randomised, double-blind, placebo-controlled, crossover experiment. The experiment was registered on ClinicalTrials.gov (NCT04851392). SETTING: Laboratory in London, United Kingdom. PARTICIPANTS: Twenty-four adolescents (12 women, 16- to 17-year-olds) and 24 adults (12 women, 26- to 29-year-olds) who used cannabis 0.5-3 days/week and were matched on cannabis use frequency (mean = 1.5 days/week). INTERVENTION: We administered three weight-adjusted vaporised cannabis flower preparations: 'THC' (8 mg THC for 75 kg person); 'THC + CBD' (8 mg THC and 24 mg CBD for 75 kg person); and 'PLA' (matched placebo). MEASUREMENTS: Primary outcomes were (i) subjective 'feel drug effect'; (ii) verbal episodic memory (delayed prose recall); and (iii) psychotomimetic effect (Psychotomimetic States Inventory). FINDINGS: Compared with 'PLA', 'THC' and 'THC + CBD' significantly (P < 0.001) increased 'feel drug effect' (mean difference [MD] = 6.3, 95% CI = 5.3-7.2; MD = 6.8, 95% CI = 6.0-7.7), impaired verbal episodic memory (MD = -2.7, 95% CI = -4.1 to -1.4; MD = -2.9, 95% CI = -4.1 to -1.7) and increased psychotomimetic effects (MD = 7.8, 95% CI = 2.8-12.7; MD = 10.8, 95% CI = 6.2-15.4). There was no evidence that adolescents differed from adults in their responses to cannabis (interaction P ≥ 0.4). Bayesian analyses supported equivalent effects of cannabis in adolescents and adults (Bayes factor [BF01 ] >3
AU  - Lawn,W
AU  - Trinci,K
AU  - Mokrysz,C
AU  - Borissova,A
AU  - Ofori,S
AU  - Petrilli,K
AU  - Bloomfield,M
AU  - Haniff,ZR
AU  - Hall,D
AU  - Fernandez-Vinson,N
AU  - Wang,S
AU  - Englund,A
AU  - Chesney,E
AU  - Wall,MB
AU  - Freeman,TP
AU  - Curran,HV
DO  - 10.1111/add.16154
EP  - 1294
PY  - 2023///
SP  - 1282
TI  - The acute effects of cannabis with and without cannabidiol in adults and adolescents: A randomised, double-blind, placebo-controlled, crossover experiment.
T2  - Addiction
UR  - http://dx.doi.org/10.1111/add.16154
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36750134
VL  - 118
ER  -
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