Imperial College London
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DrMatthewWall

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Lecturer
 
 
 
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matthew.wall

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Quelch:2017:10.1016/j.biopsych.2016.12.029,
author = {Quelch, D and Mick, I and McGonigle, J and Ramos, A and Flechais, R and Bolstridge, M and Rabiner, E and Wall, MB and Newbould, R and Steiniger-Brach, B and van, den Berg F and Boyce, M and Østergaard, Nilausen D and Breuning, Sluth L and Meulien, D and von, der Goltz C and Nutt, D and Lingford-Hughes, AR},
doi = {10.1016/j.biopsych.2016.12.029},
journal = {Biological Psychiatry},
pages = {941--948},
title = {Nalmefene reduces reward anticipation in alcohol dependence: an experimental functional magnetic resonance imaging study},
url = {http://dx.doi.org/10.1016/j.biopsych.2016.12.029},
volume = {81},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundNalmefene (Selincro®) is a µ- and δ- opioid receptor antagonist, κ-opioid receptor partial agonist that has recently been approved in Europe for treating alcohol dependence. It offers a treatment approach for alcohol dependent individuals with “high risk drinking levels” to reduce their alcohol consumption. However, the neurobiological mechanism underpinning its effects on alcohol consumption remains to be determined. Using a randomised, double blind, placebo controlled within subject cross-over design we aimed to determine the effect of a single dose of nalmefene on striatal BOLD (blood oxygen level dependent) signal change during anticipation of monetary reward using the Monetary Incentive Delay Task following alcohol challenge.Methods and Materials22 currently heavy drinking, non-treatment seeking alcohol dependent males were recruited. The effect of single dose nalmefene (18mg; Selincro®) on changes in a priori defined striatal region of interest (ROI) BOLD signal change during reward anticipation compared with placebo were investigated using functional MRI (magnetic resonance imaging). Both conditions were performed under intravenous alcohol administration (6% v/v infusion to achieve a target level of 80mg%).ResultsDatasets from 18 participants were available and showed that in the presence of the alcohol infusion, nalmefene significantly reduced the BOLD response in the striatal ROI compared with placebo. Nalmefene did not alter brain perfusion.DiscussionNalmefene blunts BOLD response in the mesolimbic system during anticipation of monetary reward and an alcohol infusion. This is consistent with nalmefene’s actions on opiate receptors, which modulate the mesolimbic dopaminergic system, and provides a neurobiological basis for its efficacy.
AU  - Quelch,D
AU  - Mick,I
AU  - McGonigle,J
AU  - Ramos,A
AU  - Flechais,R
AU  - Bolstridge,M
AU  - Rabiner,E
AU  - Wall,MB
AU  - Newbould,R
AU  - Steiniger-Brach,B
AU  - van,den Berg F
AU  - Boyce,M
AU  - Østergaard,Nilausen D
AU  - Breuning,Sluth L
AU  - Meulien,D
AU  - von,der Goltz C
AU  - Nutt,D
AU  - Lingford-Hughes,AR
DO  - 10.1016/j.biopsych.2016.12.029
EP  - 948
PY  - 2017///
SN  - 1873-2402
SP  - 941
TI  - Nalmefene reduces reward anticipation in alcohol dependence: an experimental functional magnetic resonance imaging study
T2  - Biological Psychiatry
UR  - http://dx.doi.org/10.1016/j.biopsych.2016.12.029
UR  - http://hdl.handle.net/10044/1/43678
VL  - 81
ER  -
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