Imperial College London
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DrMatthewWall

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Honorary Senior Lecturer
 
 
 
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Contact

 

matthew.wall

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Freeman:2017:ijnp/pyx082,
author = {Freeman, TP and Pope, RA and Wall, MB and Bisby, JA and Luijten, M and Hindocha, C and Mokrysz, C and Lawn, W and Moss, A and Bloomfield, MAP and Morgan, CJA and Nutt, DJ and Curran, HV},
doi = {ijnp/pyx082},
journal = {International Journal of Neuropsychopharmacology},
pages = {21--32},
title = {Cannabis dampens the effects of music in brain regions sensitive to reward and emotion},
url = {http://dx.doi.org/10.1093/ijnp/pyx082},
volume = {21},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Despite the current shift towards permissive cannabis policies, few studies have investigated the pleasurable effects users seek. Here we investigate the effects of cannabis on listening to music - a rewarding activity that frequently occurs in the context of recreational cannabis use. We additionally tested how these effects are influenced by cannabidiol (CBD), which may offset cannabis-related harms. Methods: Across three sessions, sixteen cannabis users inhaled cannabis with CBD, cannabis without CBD, and placebo. We compared their response to music relative to control excerpts of scrambled sound during functional Magnetic Resonance Imaging (fMRI) within regions identified in a meta-analysis of music-evoked reward and emotion. All results were False Discovery Rate corrected (p<0.05). Results: Compared to placebo, cannabis without CBD dampened response to music in bilateral auditory cortex (right: p=0.005, left: p=0.008), right hippocampus/parahippocampal gyrus (p=0.025), right amygdala (p=0.025) and right ventral striatum (p=0.033). Across all sessions, the effects of music in this ventral striatal region correlated with pleasure ratings (p=0.002) and increased functional connectivity with auditory cortex (right: p=0.000, left: p=0.000), supporting its involvement in music reward. Functional connectivity between right ventral striatum and auditory cortex was increased by CBD (right: p=0.003, left: p=0.030), and cannabis with CBD did not differ from placebo on any fMRI measures. Both types of cannabis increased ratings of wanting to listen to music (p<0.002) and enhanced sound perception (p<0.001). Conclusions: Cannabis dampens the effects of music in brain regions sensitive to reward and emotion. These effects were offset by a key cannabis constituent, cannabidol.
AU  - Freeman,TP
AU  - Pope,RA
AU  - Wall,MB
AU  - Bisby,JA
AU  - Luijten,M
AU  - Hindocha,C
AU  - Mokrysz,C
AU  - Lawn,W
AU  - Moss,A
AU  - Bloomfield,MAP
AU  - Morgan,CJA
AU  - Nutt,DJ
AU  - Curran,HV
DO  - ijnp/pyx082
EP  - 32
PY  - 2017///
SN  - 1461-1457
SP  - 21
TI  - Cannabis dampens the effects of music in brain regions sensitive to reward and emotion
T2  - International Journal of Neuropsychopharmacology
UR  - http://dx.doi.org/10.1093/ijnp/pyx082
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29025134
UR  - http://hdl.handle.net/10044/1/55673
VL  - 21
ER  -
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