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@article{Merkenschlager:2016:10.1146/annurev-genom-083115-022339,
author = {Merkenschlager, M and Nora, EP},
doi = {10.1146/annurev-genom-083115-022339},
journal = {Annual Review of Genomics and Human Genetics},
title = {CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation},
url = {http://dx.doi.org/10.1146/annurev-genom-083115-022339},
volume = {17},
year = {2016}
}

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TY  - JOUR
AB  - Genome function, replication, integrity, and propagation rely on the dynamic structural organization of chromosomes during the cell cycle.Genome folding in interphase provides regulatory segmentation for appropriate transcriptional control, facilitates ordered genome replication, and contributes to genome integrity by limiting illegitimate recombination. Here, we review recent high-resolution chromosome conformation capture and functional studies that have informed models of the spatial and regulatory compartmentalization of mammalian genomes, and discuss mechanistic models for how CTCF and cohesin control the functional architecture of mammalian chromosomes. Expected final online publication date for the Annual Review of Genomics and Human Genetics Volume 17 is August 31, 2016. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.
AU  - Merkenschlager,M
AU  - Nora,EP
DO  - 10.1146/annurev-genom-083115-022339
PY  - 2016///
SN  - 1545-293X
TI  - CTCF and Cohesin in Genome Folding and Transcriptional Gene Regulation
T2  - Annual Review of Genomics and Human Genetics
UR  - http://dx.doi.org/10.1146/annurev-genom-083115-022339
VL  - 17
ER  -

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