Imperial College London
Alternate

ProfessorMarie-ClaudeBoily

Faculty of Medicine, School of Public Health

Professor of Mathematical Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3263mc.boily

 
 
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Location

 

LG26Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mboup:2018:10.1002/jia2.25208,
author = {Mboup, A and Behanzin, L and Guedou, FA and Geraldo, N and Goma-Matsetse, E and Giguere, K and Aza-Gnandji, M and Kessou, L and Diallo, M and Keke, RK and Bachabi, M and Dramane, K and Geidelberg, L and Cianci, F and Lafrance, C and Affolabi, D and Diabate, S and Gagnon, M-P and Zannou, DM and Gangbo, F and Boily, M-C and Vickerman, P and Alary, M},
doi = {10.1002/jia2.25208},
journal = {Journal of the International AIDS Society},
title = {Early antiretroviral therapy and daily pre-exposure prophylaxis for HIV prevention among female sex workers in Cotonou, Benin: a prospective observational demonstration study},
url = {http://dx.doi.org/10.1002/jia2.25208},
volume = {21},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - IntroductionIn subSaharan Africa, HIV prevalence remains high, especially among key populations. In such situations, combination prevention including clinical, behavioural, structural and biological components, as well as adequate treatment are important. We conducted a demonstration project at the Dispensaire IST, a clinic dedicated to female sex workers (FSWs) in Cotonou, on early antiretroviral therapy (EART, or immediate “testandtreat”) and preexposure prophylaxis (PrEP). We present key indicators such as uptake, retention and adherence.MethodsIn this prospective observational study, we recruited FSWs from October 4th 2014 to December 31st 2015 and followed them until December 31st 2016. FSWs were provided with daily tenofovir disoproxil fumarate/emtricitabine (Truvada®) for PrEP or received a firstline antiretroviral regimen as per Benin guidelines. We used generalized estimating equations to assess trends in adherence and sexual behaviour.ResultsAmong FSWs in the catchment area, HIV testing coverage within the study framework was 95.5% (422/442). At baseline, HIV prevalence was 26.3% (111/422). Among eligible FSWs, 95.5% (105/110) were recruited for EART and 88.3% (256/290) for PrEP. Overall retention at the end of the study was 59.0% (62/105) for EART and 47.3% (121/256) for PrEP. Mean (±SD) duration of followup was 13.4 (±7.9) months for EART and 11.8 (±7.9) months for PrEP. Selfreported adherence was over 90% among most EART participants. For PrEP, adherence was lower and the proportion with 100% adherence decreased over time from 78.4% to 56.7% (ptrend < 0.0001). During the 250.1 personyears of followup among PrEP initiators, two seroconversions occurred (incidence 0.8/100 personyears (95% confidence interval: 0.3 to 1.9/100 personyears)). The two seroconverters had stopped using PrEP for at least six months before being found HIVinfected. In both groups, there was no evidence of reduced condom use.
AU  - Mboup,A
AU  - Behanzin,L
AU  - Guedou,FA
AU  - Geraldo,N
AU  - Goma-Matsetse,E
AU  - Giguere,K
AU  - Aza-Gnandji,M
AU  - Kessou,L
AU  - Diallo,M
AU  - Keke,RK
AU  - Bachabi,M
AU  - Dramane,K
AU  - Geidelberg,L
AU  - Cianci,F
AU  - Lafrance,C
AU  - Affolabi,D
AU  - Diabate,S
AU  - Gagnon,M-P
AU  - Zannou,DM
AU  - Gangbo,F
AU  - Boily,M-C
AU  - Vickerman,P
AU  - Alary,M
DO  - 10.1002/jia2.25208
PY  - 2018///
SN  - 1758-2652
TI  - Early antiretroviral therapy and daily pre-exposure prophylaxis for HIV prevention among female sex workers in Cotonou, Benin: a prospective observational demonstration study
T2  - Journal of the International AIDS Society
UR  - http://dx.doi.org/10.1002/jia2.25208
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000451836900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/65131
VL  - 21
ER  -
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