Imperial College London
Alternate

ProfessorMarie-ClaudeBoily

Faculty of Medicine, School of Public Health

Professor of Mathematical Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3263mc.boily

 
 
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Location

 

LG26Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Mitchell:2019:10.1002/jia2.25246,
author = {Mitchell, KM and Hoots, B and German, D and FLynn, C and Farley, J and Gelman, M and Hughes, J and DOnnell, D and Adeyeye, A and Remien, R and Beyrer, C and Paz, Bailey G and Boily, M-C},
doi = {10.1002/jia2.25246},
journal = {Journal of the International AIDS Society},
title = {Improvements in the HIV care continuum needed to meaningfully reduce HIV incidence among men who have sex with men in Baltimore, US: a modelling study for HPTN 078},
url = {http://dx.doi.org/10.1002/jia2.25246},
volume = {22},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction HIV prevalence is high among men who have sex with men (MSM) in Baltimore, Maryland, United States, and levels of viral suppression among HIV-positive MSM are relatively low. The HIV Prevention Trials Network (HPTN) 078 trial seeks to increase levels of viral suppression among US MSM by increasing rates of diagnosis and linkage to care and treatment. We estimated the increases in viral suppression needed to reach different HIV incidence reduction targets, and the impact of meeting diagnosis and treatment targets.Methods: We used a mathematical model of HIV transmission among MSM from Baltimore, US, parameterised with behavioural data and fitted to HIV prevalence and care continuum data for Baltimore wherever possible, to project increases in viral suppression needed to reduce the HIV incidence rate among Baltimore MSM by 10, 20, 30, or 50% after 2, 5, and 10 years. We also projected HIV incidence reductions achieved if US national targets – 90% of people living with HIV (PLHIV) know their HIV serostatus, 90% of those diagnosed are retained in HIV medical care and 80% of those diagnosed are virally suppressed - or UNAIDS 90-90-90 targets (90% of PLHIV know their status, 90% of those diagnosed receive antiretroviral therapy (ART), 90% of those receiving ART are virally suppressed) are each met by 2020.Results: To reduce the HIV incidence rate by 20% and 50% after 5 years (compared with the base-case at the same time point), the proportion of all HIV-positive MSM who are virally suppressed must increase above 2015 levels by a median 13 percentage points (95% uncertainty interval 9-16 percentage points) from median 49% to 60%, and 27 percentage points (22-35) from 49% to 75%, respectively. Meeting all three US or 90-90-90 UNAIDS targets results in a 48% (31-63%) and 51% (38-65%) HIV incidence rate reduction in 2020, respectively. Conclusions: Substantial improvements in levels of viral suppression will be needed to achieve significant incidence reduct
AU  - Mitchell,KM
AU  - Hoots,B
AU  - German,D
AU  - FLynn,C
AU  - Farley,J
AU  - Gelman,M
AU  - Hughes,J
AU  - DOnnell,D
AU  - Adeyeye,A
AU  - Remien,R
AU  - Beyrer,C
AU  - Paz,Bailey G
AU  - Boily,M-C
DO  - 10.1002/jia2.25246
PY  - 2019///
SN  - 1758-2652
TI  - Improvements in the HIV care continuum needed to meaningfully reduce HIV incidence among men who have sex with men in Baltimore, US: a modelling study for HPTN 078
T2  - Journal of the International AIDS Society
UR  - http://dx.doi.org/10.1002/jia2.25246
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/jia2.25246
UR  - http://hdl.handle.net/10044/1/67177
VL  - 22
ER  -
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