Imperial College London
Alternate

ProfessorMarie-ClaudeBoily

Faculty of Medicine, School of Public Health

Professor of Mathematical Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3263mc.boily

 
 
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Location

 

LG26Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stannah:2019:10.1007/s10461-019-02651-0,
author = {Stannah, J and Silhol, R and Elmes, J and Owen, B and Shacklett, BL and Anton, P and McGowan, I and van, der Straten A and Dimitrov, D and Baggaley, RF and Boily, M-C},
doi = {10.1007/s10461-019-02651-0},
journal = {AIDS and Behavior},
pages = {667--681},
title = {Increases in HIV incidence following receptive anal intercourse among women: A systematic review and meta-analysis.},
url = {http://dx.doi.org/10.1007/s10461-019-02651-0},
volume = {24},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Receptive anal intercourse (RAI) carries a greater per-act risk of HIV acquisition than receptive vaginal intercourse (RVI) and may influence HIV epidemics driven by heterosexual sex. This systematic review explores the association between RAI and incident HIV among women, globally. We searched Embase and Medline through September 2018 for longitudinal studies reporting crude (cRR) or adjusted (aRR) relative risks of HIV acquisition by RAI practice among women. Of 27,563 articles identified, 17 eligible studies were included. We pooled independent study estimates using random-effects models. Women reporting RAI were more likely to acquire HIV than women not reporting RAI (pooled cRR = 1.56 95% CI 1.03-2.38, N = 18, I2 = 72%; pooled aRR = 2.23, 1.01-4.92, N = 5, I2 = 70%). In subgroup analyses the association was lower for women in Africa (pooled cRR = 1.16, N = 13, I2 = 21%) than outside Africa (pooled cRR = 4.10, N = 5, I2 = 79%) and for high-risk (pooled aRR = 1.69, N = 4, I2 = 63%) than general-risk women (pooled aRR = 8.50, N = 1). Interview method slightly influenced cRR estimates (p value = 0.04). In leave-one-out sensitivity analyses pooled estimates were generally robust to removing individual study estimates. Main limitations included poor exposure definition, incomplete adjustment for confounders, particularly condom use, and use of non-confidential interview methods. More and better data are needed to explain differences in risk by world region and risk population. Women require better counselling and greater choice in prevention modalities that are effective during RVI and RAI.
AU  - Stannah,J
AU  - Silhol,R
AU  - Elmes,J
AU  - Owen,B
AU  - Shacklett,BL
AU  - Anton,P
AU  - McGowan,I
AU  - van,der Straten A
AU  - Dimitrov,D
AU  - Baggaley,RF
AU  - Boily,M-C
DO  - 10.1007/s10461-019-02651-0
EP  - 681
PY  - 2019///
SN  - 1090-7165
SP  - 667
TI  - Increases in HIV incidence following receptive anal intercourse among women: A systematic review and meta-analysis.
T2  - AIDS and Behavior
UR  - http://dx.doi.org/10.1007/s10461-019-02651-0
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31486008
UR  - https://link.springer.com/article/10.1007%2Fs10461-019-02651-0
UR  - http://hdl.handle.net/10044/1/73520
VL  - 24
ER  -
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