Imperial College London
Alternate

ProfessorMarie-ClaudeBoily

Faculty of Medicine, School of Public Health

Professor of Mathematical Epidemiology
 
 
 
//

Contact

 

+44 (0)20 7594 3263mc.boily

 
 
//

Location

 

LG26Norfolk PlaceSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Looker:2020:10.1016/S1473-3099(19)30470-0,
author = {Looker, K and Welton, N and Sabin, K and Dalal, S and Vickerman, P and Turner, K and Boily, M-C and Boily, M-C and Gottlieb, S},
doi = {10.1016/S1473-3099(19)30470-0},
journal = {Lancet Infectious Diseases},
pages = {240--249},
title = {Global and regional estimates of the contribution of herpes simplex virus Type 2 infection to HIV incidence: a population attributable fraction analysis using published epidemiological data},
url = {http://dx.doi.org/10.1016/S1473-3099(19)30470-0},
volume = {20},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundA 2017 systematic review and meta-analysis of 55 prospective studies found the adjusted risk of HIV acquisition to be at least tripled in individuals with herpes simplex virus type 2 (HSV-2) infection. We aimed to assess the potential contribution of HSV-2 infection to HIV incidence, given an effect of HSV-2 on HIV acquisition.MethodsWe used a classic epidemiological formula to estimate the global and regional (WHO regional) population attributable fraction (PAF) and number of incident HIV infections attributable to HSV-2 infection by age (15–24 years, 25–49 years, and 15–49 years), sex, and timing of HSV-2 infection (established vs recently acquired). Estimates were calculated by incorporating HSV-2 and HIV infection data with pooled relative risk (RR) estimates for the effect of HSV-2 infection on HIV acquisition from a systematic review and meta-analysis. Because HSV-2 and HIV have shared sexual and other risk factors, in addition to HSV-related biological factors that increase HIV risk, we only used RR estimates that were adjusted for potential confounders.FindingsAn estimated 420000 (95% uncertainty interval 317000–546000; PAF 29·6% [22·9–37·1]) of 1·4 million sexually acquired incident HIV infections in individuals aged 15–49 years in 2016 were attributable to HSV-2 infection. The contribution of HSV-2 to HIV was largest for the WHO African region (PAF 37·1% [28·7–46·3]), women (34·8% [23·5–45·0]), individuals aged 25–49 years (32·4% [25·4–40·2]), and established HSV-2 infection (26·8% [19·7–34·5]).InterpretationA large burden of HIV is likely to be attributable to HSV-2 infection, even if the effect of HSV-2 infection on HIV had been imperfectly measured in studies providing adjusted RR estimates, potentially because of residual confounding. The contribution is likely to
AU  - Looker,K
AU  - Welton,N
AU  - Sabin,K
AU  - Dalal,S
AU  - Vickerman,P
AU  - Turner,K
AU  - Boily,M-C
AU  - Boily,M-C
AU  - Gottlieb,S
DO  - 10.1016/S1473-3099(19)30470-0
EP  - 249
PY  - 2020///
SN  - 1473-3099
SP  - 240
TI  - Global and regional estimates of the contribution of herpes simplex virus Type 2 infection to HIV incidence: a population attributable fraction analysis using published epidemiological data
T2  - Lancet Infectious Diseases
UR  - http://dx.doi.org/10.1016/S1473-3099(19)30470-0
UR  - https://www.sciencedirect.com/science/article/pii/S1473309919304700?via%3Dihub
UR  - http://hdl.handle.net/10044/1/76014
VL  - 20
ER  -
Download