Imperial College London
Alternate

ProfessorMarie-ClaudeBoily

Faculty of Medicine, School of Public Health

Professor of Mathematical Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3263mc.boily

 
 
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Location

 

LG26Norfolk PlaceSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Elmes:2020:10.1111/aji.13263,
author = {Elmes, J and Silhol, R and Hess, KL and Gedge, LM and Nordsletten, A and Staunton, R and Anton, P and Shacklett, B and McGowan, I and Dang, Q and Adimora, AA and Dimitrov, DT and Aral, S and Handanagic, S and PazBailey, G and Boily, M},
doi = {10.1111/aji.13263},
journal = {American Journal of Reproductive Immunology},
pages = {1--14},
title = {Receptive anal sex contributes substantially to heterosexuallyacquired HIV infections among atrisk women in Twenty US Cities: results from a modelling analysis},
url = {http://dx.doi.org/10.1111/aji.13263},
volume = {84},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ProblemReceptive anal intercourse (RAI) is more efficient than receptive vaginal intercourse (RVI) at transmitting HIV, but its contribution to heterosexuallyacquired HIV infections among atrisk women in the US is unclear.Method of studyWe analysed sexual behaviour data from surveys of 9,152 lowincome heterosexual women living in 20 cities with high rates of HIV conducted in 2010 and 2013 as part of US National HIV Behavioral Surveillance. We estimated RAI prevalence (pastyear RAI) and RAI fraction (fraction of all sex acts (RVI and RAI) at the last sexual episode that were RAI among those reporting pastyear RAI) overall and by key demographic characteristics. These results and HIV incidence were used to calibrate a riskequation model to estimate the population attributable fraction of new HIV infections due to RAI (PAFRAI) accounting for uncertainty in parameter assumptions.ResultsRAI prevalence (overall: 32%, city range: 1960%) and RAI fraction (overall: 27%, cityrange: 1834%) were high overall and across cities, and positively associated with exchange sex. RAI accounted for an estimated 41% (uncertainty range: 1855%) of new infections overall (city range: 2157%). Variability in PAFRAI estimates was most influenced by uncertainty in the estimate of the peract increased risk of RAI relative to RVI and the number of sex acts.ConclusionsRAI may contribute disproportionately to new heterosexuallyacquired HIV infections among atrisk lowincome women in the US, meaning that tools to prevent HIV transmission during RAI are warranted. Number of RVI and RAI acts should also be collected to monitor heterosexuallyacquired HIV infections.
AU  - Elmes,J
AU  - Silhol,R
AU  - Hess,KL
AU  - Gedge,LM
AU  - Nordsletten,A
AU  - Staunton,R
AU  - Anton,P
AU  - Shacklett,B
AU  - McGowan,I
AU  - Dang,Q
AU  - Adimora,AA
AU  - Dimitrov,DT
AU  - Aral,S
AU  - Handanagic,S
AU  - PazBailey,G
AU  - Boily,M
DO  - 10.1111/aji.13263
EP  - 14
PY  - 2020///
SN  - 1046-7408
SP  - 1
TI  - Receptive anal sex contributes substantially to heterosexuallyacquired HIV infections among atrisk women in Twenty US Cities: results from a modelling analysis
T2  - American Journal of Reproductive Immunology
UR  - http://dx.doi.org/10.1111/aji.13263
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1111/aji.13263
UR  - http://hdl.handle.net/10044/1/79107
VL  - 84
ER  -
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