Imperial College London
Alternate

Professor MENGXING TANG

Faculty of Engineering, Department of Bioengineering

Professor of Biomedical Imaging
 
 
 
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Contact

 

+44 (0)20 7594 3664mengxing.tang Website

 
 
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Location

 

3.13Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Riemer:2020:10.1007/s10439-020-02484-2,
author = {Riemer, K and Rowland, EM and Leow, CH and Tang, MX and Weinberg, PD},
doi = {10.1007/s10439-020-02484-2},
journal = {Annals of Biomedical Engineering},
pages = {1728--1739},
title = {Determining haemodynamic wall shear stress in the rabbit aorta in vivo using contrast-enhanced ultrasound image velocimetry},
url = {http://dx.doi.org/10.1007/s10439-020-02484-2},
volume = {48},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Abnormal blood flow and wall shear stress (WSS) can cause and be caused by cardiovascular disease. To date, however, no standard method has been established for mapping WSS in vivo. Here we demonstrate wide-field assessment of WSS in the rabbit abdominal aorta using contrast-enhanced ultrasound image velocimetry (UIV). Flow and WSS measurements were made independent of beam angle, curvature or branching. Measurements were validated in an in silico model of the rabbit thoracic aorta with moving walls and pulsatile flow. Mean errors over a cardiac cycle for velocity and WSS were 0.34 and 1.69%, respectively. In vivo time average WSS in a straight segment of the suprarenal aorta correlated highly with simulations (PC = 0.99) with a mean deviation of 0.29 Pa or 5.16%. To assess fundamental plausibility of the measurement, UIV WSS was compared to an analytic approximation derived from the Poiseuille equation; the discrepancy was 17%. Mapping of WSS was also demonstrated in regions of arterial branching. High time average WSS (TAWSSxz = 3.4 Pa) and oscillatory flow (OSIxz = 0.3) were observed near the origin of conduit arteries. In conclusion, we have demonstrated that contrast-enhanced UIV is capable of measuring spatiotemporal variation in flow velocity, arterial wall location and hence WSS in vivo with high accuracy over a large field of view.
AU  - Riemer,K
AU  - Rowland,EM
AU  - Leow,CH
AU  - Tang,MX
AU  - Weinberg,PD
DO  - 10.1007/s10439-020-02484-2
EP  - 1739
PY  - 2020///
SN  - 0090-6964
SP  - 1728
TI  - Determining haemodynamic wall shear stress in the rabbit aorta in vivo using contrast-enhanced ultrasound image velocimetry
T2  - Annals of Biomedical Engineering
UR  - http://dx.doi.org/10.1007/s10439-020-02484-2
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000539098200012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://link.springer.com/article/10.1007%2Fs10439-020-02484-2
UR  - http://hdl.handle.net/10044/1/82510
VL  - 48
ER  -
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