Imperial College London
Alternate

Professor MENGXING TANG

Faculty of Engineering, Department of Bioengineering

Professor of Biomedical Imaging
 
 
 
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Contact

 

+44 (0)20 7594 3664mengxing.tang Website

 
 
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Location

 

3.13Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Weinberg:2022:10.1016/j.ultrasmedbio.2021.10.010,
author = {Weinberg, P and Riemer, K and Rowland, E and Broughton-Venner, J and Leow, CH and Tang, M},
doi = {10.1016/j.ultrasmedbio.2021.10.010},
journal = {Ultrasound in Medicine and Biology},
pages = {437--449},
title = {Contrast agent free assessment of blood flow and wall shear stress in the rabbit aorta using ultrasound image velocimetry},
url = {http://dx.doi.org/10.1016/j.ultrasmedbio.2021.10.010},
volume = {48},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Blood flow velocity and wall shear stress (WSS) influence and are influencedby vascular disease. Their measurement is consequently useful in the laboratory and clinic. Contrast enhanced ultrasound image velocimetry (UIV) canestimate them accurately but the need to inject contrast agents limits utility. Singular value decomposition and high frame rate imaging may rendercontrast agents dispensable. Here we determined whether contrast agent freeUIV can measure flow and WSS. In simulation, accurate measurements wereachieved with a signal-to-noise ratio of 13.5 dB or higher. Signal intensity inthe rabbit aorta increased monotonically with mechanical index and was lowest during stagnant flow and uneven across the vessel. In vivo measurementswith contrast free and contrast enhanced UIV differed by 4.4 % and 1.9 % forvelocity magnitude and angle and by 9.47 % for WSS. Bland–Altman analysis of waveforms showed good agreement between contrast free and contrast enhanced UIV. In five rabbits the root-mean-square error was as low as 0.022m/s (0.81 %) and 0.11 Pa (1.7 %). This study demonstrates that with anoptimised protocol, UIV can assess flow and WSS without contrast agents.Unlike contrast enhanced UIV, it could be routinely employed.
AU  - Weinberg,P
AU  - Riemer,K
AU  - Rowland,E
AU  - Broughton-Venner,J
AU  - Leow,CH
AU  - Tang,M
DO  - 10.1016/j.ultrasmedbio.2021.10.010
EP  - 449
PY  - 2022///
SN  - 0301-5629
SP  - 437
TI  - Contrast agent free assessment of blood flow and wall shear stress in the rabbit aorta using ultrasound image velocimetry
T2  - Ultrasound in Medicine and Biology
UR  - http://dx.doi.org/10.1016/j.ultrasmedbio.2021.10.010
UR  - https://www.sciencedirect.com/science/article/pii/S0301562921004506?via%3Dihub
UR  - http://hdl.handle.net/10044/1/92641
VL  - 48
ER  -
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