Imperial College London

DrMichaelCox

Faculty of MedicineNational Heart & Lung Institute

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 7974michael.cox1 Website

 
 
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Location

 

413Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cox:2010,
author = {Cox, MJ and Huang, YJ and Fujimura, KE and Liu, JT and McKean, M and Boushey, HA and Segal, MR and Brodie, EL and Cabana, MD and Lynch, SV},
journal = {PloS one},
pages = {e8745--e8745},
title = {Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome.},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20090909},
volume = {5},
year = {2010}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Colonization of the infant gut by microorganisms over the first year of life is crucial for development of a balanced immune response. Early alterations in the gastrointestinal microbiota of neonates has been linked with subsequent development of asthma and atopy in older children. Here we describe high-resolution culture-independent analysis of stool samples from 6-month old infants fed daily supplements of Lactobacillus casei subsp. Rhamnosus (LGG) or placebo in a double-blind, randomized Trial of Infant Probiotic Supplementation (TIPS). Bacterial community composition was examined using a high-density microarray, the 16S rRNA PhyloChip, and the microbial assemblages of infants with either high or low LGG abundance were compared. Communities with high abundance of LGG exhibited promotion of phylogenetically clustered taxa including a number of other known probiotic species, and were significantly more even in their distribution of community members. Ecologically, these aspects are characteristic of communities that are more resistant to perturbation and outgrowth of pathogens. PhyloChip analysis also permitted identification of taxa negatively correlated with LGG abundance that have previously been associated with atopy, as well as those positively correlated that may prove useful alternative targets for investigation as alternative probiotic species. From these findings we hypothesize that a key mechanism for the protective effect of LGG supplementation on subsequent development of allergic disease is through promotion of a stable, even, and functionally redundant infant gastrointestinal community.
AU - Cox,MJ
AU - Huang,YJ
AU - Fujimura,KE
AU - Liu,JT
AU - McKean,M
AU - Boushey,HA
AU - Segal,MR
AU - Brodie,EL
AU - Cabana,MD
AU - Lynch,SV
EP - 8745
PY - 2010///
SP - 8745
TI - Lactobacillus casei abundance is associated with profound shifts in the infant gut microbiome.
T2 - PloS one
UR - http://www.ncbi.nlm.nih.gov/pubmed/20090909
UR - file:///Users/mike/Documents/Mendeley%20Desktop/PloS%20one/2010/Cox%20et%20al/Cox%20et%20al._2010_Lactobacillus%20casei%20abundance%20is%20associated%20with%20profound%20shifts%20in%20the%20infant%20gut%20microbiome.pdf
VL - 5
ER -