Imperial College London

DrMichaelCox

Faculty of MedicineNational Heart & Lung Institute

Research Associate
 
 
 
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Contact

 

+44 (0)20 7594 7974michael.cox1 Website

 
 
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Location

 

413Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Huang:2010,
author = {Huang, YJ and Kim, E and Cox, MJ and Brodie, EL and Brown, R and Wiener-Kronish, JP and Lynch, SV},
journal = {Omics : a journal of integrative biology},
pages = {9--59},
title = {A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations.},
url = {http://www.ncbi.nlm.nih.gov/pubmed/20141328},
volume = {14},
year = {2010}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Acute exacerbations of chronic obstructive pulmonary disease (COPD) are a major source of morbidity and contribute significantly to healthcare costs. Although bacterial infections are implicated in nearly 50% of exacerbations, only a handful of pathogens have been consistently identified in COPD airways, primarily by culture-based methods, and the bacterial microbiota in acute exacerbations remains largely uncharacterized. The aim of this study was to comprehensively profile airway bacterial communities using a culture-independent microarray, the 16S rRNA PhyloChip, of a cohort of COPD patients requiring ventilatory support and antibiotic therapy for exacerbation-related respiratory failure. PhyloChip analysis revealed the presence of over 1,200 bacterial taxa representing 140 distinct families, many previously undetected in airway diseases; bacterial community composition was strongly influenced by the duration of intubation. A core community of 75 taxa was detected in all patients, many of which are known pathogens. Bacterial community diversity in COPD airways is substantially greater than previously recognized and includes a number of potential pathogens detected in the setting of antibiotic exposure. Comprehensive assessment of the COPD airway microbiota using high-throughput, culture-independent methods may prove key to understanding the relationships between airway bacterial colonization, acute exacerbation, and clinical outcomes in this and other chronic inflammatory airway diseases.
AU - Huang,YJ
AU - Kim,E
AU - Cox,MJ
AU - Brodie,EL
AU - Brown,R
AU - Wiener-Kronish,JP
AU - Lynch,SV
EP - 59
PY - 2010///
SP - 9
TI - A persistent and diverse airway microbiota present during chronic obstructive pulmonary disease exacerbations.
T2 - Omics : a journal of integrative biology
UR - http://www.ncbi.nlm.nih.gov/pubmed/20141328
VL - 14
ER -