Imperial College London


Faculty of MedicineNational Heart & Lung Institute

Research Associate



+44 (0)20 7594 7974michael.cox1 Website




413Guy Scadding BuildingRoyal Brompton Campus






BibTex format

author = {Molyneaux, PL and Cox, MJ and Wells, AU and Kim, HC and Ji, W and Cookson, WOC and Moffatt, MF and Kim, DS and Maher, TM},
doi = {10.1186/s12931-017-0511-3},
journal = {Respiratory Research},
title = {Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis},
url = {},
volume = {18},
year = {2017}

RIS format (EndNote, RefMan)

AB - Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) have been defined as events of clinically significant respiratory deterioration with an unidentifiable cause. They carry a significant mortality and morbidity and while their exact pathogenesis remains unclear, the possibility remains that hidden infection may play a role. The aim of this pilot study was to determine whether changes in the respiratory microbiota occur during an AE-IPF. Bacterial DNA was extracted from bronchoalveolar lavage from patients with stable IPF and those experiencing an AE-IPF. A hyper-variable region of the 16S ribosomal RNA gene (16S rRNA) was amplified, quantified and pyrosequenced. Culture independent techniques demonstrate AE-IPF is associated with an increased BAL bacterial burden compared to stable disease and highlight shifts in the composition of the respiratory microbiota during an AE-IPF.
AU - Molyneaux,PL
AU - Cox,MJ
AU - Wells,AU
AU - Kim,HC
AU - Ji,W
AU - Cookson,WOC
AU - Moffatt,MF
AU - Kim,DS
AU - Maher,TM
DO - 10.1186/s12931-017-0511-3
PY - 2017///
SN - 1465-9921
TI - Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis
T2 - Respiratory Research
UR -
UR -
VL - 18
ER -