Imperial College London

Dr Michael K.P. Liu

Faculty of MedicineDepartment of Infectious Disease

Research Associate
 
 
 
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Contact

 

+44 (0)20 3315 5986michael.liu Website

 
 
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Location

 

I.02. 03Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Summary

Michael Liu, Ph.D is a postdoctoral research associate at the new Centre For Immunology and Vaccinology. He joined the group of Prof. Xiao-Ning Xu in July 2014.

Michael Liu has been researching human T cell immunology for over a decade. He began his research career in 2001 joining the lab of Dave Sansom at the MRC Centre For Immune Regulation at the University of Birmingham as a Ph.D student. His focus there was the role of the extended CD28-B7 superfamily of costimulation of human CD4 T cells. Following a short stint at the Malawi-Liverpool Wellcome Trust Research Programme in Blantyre, Malawi, he joined the lab of Sir Andrew McMichael at the Weatherall Institute of Molecular Medicine, University of Oxford. There he investigated the role of CD8 T cells during acute HIV-1 infection and their effect upon the evolution of the virus. Current projects include employing single-cell sequencing upon CD8 T cell responses against different regions of HIV-1 and the role of T cell responses in SARS-CoV-2 infection.

Selected Publications


Yang H., Rei M., Brackenridge S., Brenna E., Sun H., Abdulhaqq S., Liu M.K.P.  et al., (2021) HLA-E-restricted, Gag-specific CD8( ) T cells can suppress HIV-1 infection, offering vaccine opportunities, Science Immunology, Vol:6. Article

Song H., Hora B., Bhattacharya T., Goonetilleke N., Liu M.K., et al., (2014) Reversion and T cell escape mutations compensate the fitness loss of a CD8 T cell escape mutant in their cognate transmitted/founder virus. PLoS One, 9, e102734. Article

Liu M.K.P., Hawkins H., Ritchie A.J., Ganusov V.V., Whale V., et al., (2013) Vertical T cell immunodominance and epitope entropy determine rate of HIV-1 escape. J. Clin. Invest., 123, 380-93. Article

Ganusov V.V., Goonetilleke N., Liu M.K.P., Ferrari G., Shaw G.M., et al., (2011) Fitness Costs and Diversity of the Cytotoxic T Lymphocyte (CTL) Response Determine the Rate of CTL Escape during Acute and Chronic Phases of HIV Infection. J. Virol. 85, 10518-28. Article

Ferrari G.*, Korber B.T.*, Goonetilleke N., Liu M.K., Turnbull E., et al., (2011) Relationship between functional profile of HIV-1 specific CD8 T cells and epitope variability with the selection of escape mutants in acute HIV-1 infection. PLOS Pathog 7, e1001273. Article

Goonetilleke N.*, Liu M.K.*, Salazar-Gonzalez J.F.*, Ferrari G., Giorgi E., et al., (2009) The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med. 206, 1253-72. *Equal contribution. Article

MacLennan C.A, Liu M.K., White S.A., van Oosterhout J.J., Simukonda F., et al., (2007) Diagnostic accuracy and clinical utility of a simplified low cost method of counting CD4 cells with flow cytometry in Malawi: diagnostic accuracy study. BMJ 335, 190-4. Article

Manzotti C.N., Liu M.K., Burke F., Sant T.A., Dussably L., et al., (2006) Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86. Eur. J. Immunol. 36, 1413-22. Article

Publications

Journals

Yang H, Rei M, Brackenridge S, et al., 2021, HLA-E-restricted, Gag-specific CD8(+) T cells can suppress HIV-1 infection, offering vaccine opportunities, Science Immunology, Vol:6, ISSN:2470-9468, Pages:1-11

Peng BJ, Carlson JM, Liu MKP, et al., 2018, Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection, Journal of Virology, Vol:92, ISSN:0022-538X

Liu D, Wang C, Hora B, et al., 2017, A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies, Retrovirology, Vol:14, ISSN:1742-4690

Song H, Hora B, Bhattacharya T, et al., 2014, Reversion and T Cell Escape Mutations Compensate the Fitness Loss of a CD8(+) T Cell Escape Mutant in Their Cognate Transmitted/Founder Virus, Plos One, Vol:9, ISSN:1932-6203

Liu MKP, Hawkins N, Ritchie AJ, et al., 2013, Vertical T cell immunodominance and epitope entropy determine HIV-1 escape, Journal of Clinical Investigation, Vol:123, ISSN:0021-9738, Pages:380-393

More Publications