Publications
223 results found
Way M, McQuillin A, Saini J, et al., 2015, Genetic variants in or near ADH1B and ADH1C affect susceptibility to alcohol dependence in a British and Irish population., Addict Biol, Vol: 20, Pages: 594-604
Certain single nucleotide polymorphisms (SNPs) in genes encoding alcohol dehydrogenase (ADH) enzymes confer a significant protective effect against alcohol dependence syndrome (ADS) in East Asian populations. Recently, attention has focused on the role of these SNPs in determining ADS risk in European populations. To further elucidate these associations, SNPs of interest in ADH1B, ADH1C and the ADH1B/1C intergenic region were genotyped in a British and Irish population (ADS cases n = 1076: controls n = 1027) to assess their relative contribution to ADS risk. A highly significant, protective association was observed between the minor allele of rs1229984 in ADH1B and ADS risk [allelic P = 8.4 × 10(-6) , odds ratio (OR) = 0.26, 95 percent confidence interval, 0.14, 0.49]. Significant associations were also observed between ADS risk and the ADH1B/1C intergenic variant, rs1789891 [allelic P = 7.2 × 10(-5) , OR = 1.4 (1.2, 1.6)] and three non-synonymous SNPs rs698, rs1693482 and rs283413 in ADH1C. However, these associations were not completely independent; thus, while the ADH1B rs1229984 minor allele association was independent of those of the intergenic variant rs1789891 and the three ADH1C variants, the three ADH1C variants were not individually independent. In conclusion, the rare ADH1B rs1229984 mutation provides significant protection against ADS in this British and Irish population; other variants in the ADH gene cluster also alter ADS risk, although the strong linkage disequilibrium between SNPs at this location precluded clear identification of the variant(s) driving the associations.
Barry DJ, Durkin CH, Abella JV, et al., 2015, Open source software for quantification of cell migration, protrusions, and fluorescence intensities, JOURNAL OF CELL BIOLOGY, Vol: 209, Pages: 163-180, ISSN: 0021-9525
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- Citations: 97
Way M, 2015, 2014 Winners: Anne-Lise Gaffuri and Elizabeth Crowell, JOURNAL OF CELL SCIENCE, Vol: 128, Pages: 1255-1256, ISSN: 0021-9533
Way M, Ahmad SA, 2015, JCS Editor changes, JOURNAL OF CELL SCIENCE, Vol: 128, Pages: 831-831, ISSN: 0021-9533
Gill MB, Turner R, Stevenson PG, et al., 2015, KSHV-TK is a tyrosine kinase that disrupts focal adhesions and induces Rho-mediated cell contraction, EMBO JOURNAL, Vol: 34, Pages: 448-465, ISSN: 0261-4189
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- Citations: 13
Young JC, Clements A, Lang AE, et al., 2014, The Escherichia coli effector EspJ blocks Src kinase activity via amidation and ADP ribosylation, Nature Communications, Vol: 5, ISSN: 2041-1723
The hallmark of enteropathogenic Escherichia coli (EPEC) infection is the formation of actin-rich pedestal-like structures, which are generated following phosphorylation of the bacterial effector Tir by cellular Src and Abl family tyrosine kinases. This leads to recruitment of the Nck–WIP–N-WASP complex that triggers Arp2/3-dependent actin polymerization in the host cell. The same phosphorylation-mediated signalling network is also assembled downstream of the Vaccinia virus protein A36 and the phagocytic Fc-gamma receptor FcγRIIa. Here we report that the EPEC type-III secretion system effector EspJ inhibits autophosphorylation of Src and phosphorylation of the Src substrates Tir and FcγRIIa. Consistent with this, EspJ inhibits actin polymerization downstream of EPEC, Vaccinia virus and opsonized red blood cells. We identify EspJ as a unique adenosine diphosphate (ADP) ribosyltransferase that directly inhibits Src kinase by simultaneous amidation and ADP ribosylation of the conserved kinase-domain residue, Src E310, resulting in glutamine-ADP ribose.
O'Brien NL, Way MJ, Kandaswamy R, et al., 2014, The functional GRM3 Kozak sequence variant rs148754219 affects the risk of schizophrenia and alcohol dependence as well as bipolar disorder., Psychiatr Genet, Vol: 24, Pages: 277-278
Chen XJ, Squarr AJ, Stephan R, et al., 2014, Ena/VASP Proteins Cooperate with the WAVE Complex to Regulate the Actin Cytoskeleton, DEVELOPMENTAL CELL, Vol: 30, Pages: 569-584, ISSN: 1534-5807
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- Citations: 75
Quadri G, McQuillin A, Guerrini I, et al., 2014, Evidence for genetic susceptibility to the alcohol dependence syndrome from the thiamine transporter 2 gene solute carrier SLC19A3., Psychiatr Genet, Vol: 24, Pages: 122-123
Way M, 2014, 2013 Winner: Liam Cheeseman, JOURNAL OF CELL SCIENCE, Vol: 127, Pages: 2121-2121, ISSN: 0021-9533
Humphries AC, Donnelly SK, Way M, 2014, Cdc42 and the Rho GEF intersectin-1 collaborate with Nck to promote N-WASP-dependent actin polymerisation, JOURNAL OF CELL SCIENCE, Vol: 127, Pages: 673-685, ISSN: 0021-9533
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- Citations: 38
Way M, Ahmad SA, 2013, New JCS editor, Journal of Cell Science, Vol: 126, ISSN: 0021-9533
Welch MD, Way M, 2013, Arp2/3-Mediated Actin-Based Motility: A Tail of Pathogen Abuse, CELL HOST & MICROBE, Vol: 14, Pages: 242-255, ISSN: 1931-3128
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- Citations: 144
Humphries AC, Way M, 2013, The non-canonical roles of clathrin and actin in pathogen internalization, egress and spread, NATURE REVIEWS MICROBIOLOGY, Vol: 11, Pages: 551-560, ISSN: 1740-1526
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- Citations: 38
Handa Y, Durkin CH, Dodding MP, et al., 2013, Vaccinia Virus F11 Promotes Viral Spread by Acting as a PDZ-Containing Scaffolding Protein to Bind Myosin-9A and Inhibit RhoA Signaling, CELL HOST & MICROBE, Vol: 14, Pages: 51-62, ISSN: 1931-3128
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- Citations: 31
Donnelly SK, Weisswange I, Zettl M, et al., 2013, WIP Provides an Essential Link between Nck and N-WASP during Arp2/3-Dependent Actin Polymerization, CURRENT BIOLOGY, Vol: 23, Pages: 999-1006, ISSN: 0960-9822
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- Citations: 44
Gerlic M, Faustin B, Postigo A, et al., 2013, Vaccinia virus F1L protein promotes virulence by inhibiting inflammasome activation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 110, Pages: 7808-7813, ISSN: 0027-8424
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- Citations: 69
Way M, Ahmad SA, 2013, The San Francisco Declaration on Research Assessment, JOURNAL OF CELL SCIENCE, Vol: 126, Pages: 1903-1904, ISSN: 0021-9533
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- Citations: 3
Way M, 2013, 2012 winners: Vincent pasque and aliaksandra radzisheuskaya, Journal of Cell Science, Vol: 126, Pages: 1287-1288, ISSN: 0021-9533
Stricker SH, Feber A, Engstroem PG, et al., 2013, Widespread resetting of DNA methylation in glioblastoma-initiating cells suppresses malignant cellular behavior in a lineage-dependent manner, GENES & DEVELOPMENT, Vol: 27, Pages: 654-669, ISSN: 0890-9369
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- Citations: 108
Wiezlak M, Diring J, Abella J, et al., 2012, G-actin regulates the shuttling and PP1 binding of the RPEL protein Phactr1 to control actomyosin assembly, JOURNAL OF CELL SCIENCE, Vol: 125, Pages: 5860-5872, ISSN: 0021-9533
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- Citations: 46
Humphries AC, Dodding MP, Barry DJ, et al., 2012, Clathrin Potentiates Vaccinia-Induced Actin Polymerization to Facilitate Viral Spread, CELL HOST & MICROBE, Vol: 12, Pages: 346-359, ISSN: 1931-3128
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- Citations: 41
Lynn H, Horsington J, Ter LK, et al., 2012, Loss of Cytoskeletal Transport during Egress Critically Attenuates Ectromelia Virus Infection <i>In Vivo</i>, JOURNAL OF VIROLOGY, Vol: 86, Pages: 7427-7443, ISSN: 0022-538X
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- Citations: 19
Dart AE, Donnelly SK, Holden DW, et al., 2012, Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis, JOURNAL OF CELL SCIENCE, Vol: 125, Pages: 2825-2830, ISSN: 0021-9533
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- Citations: 31
Ahrens S, Zelenay S, Sancho D, et al., 2012, F-Actin Is an Evolutionarily Conserved Damage-Associated Molecular Pattern Recognized by DNGR-1, a Receptor for Dead Cells, IMMUNITY, Vol: 36, Pages: 635-645, ISSN: 1074-7613
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- Citations: 284
Way M, 2012, A fresh start - but business as usual, JOURNAL OF CELL SCIENCE, Vol: 125, Pages: 1-2, ISSN: 0021-9533
Postigo A, Way M, 2012, The Vaccinia Virus-Encoded Bcl-2 Homologues Do Not Act as Direct Bax Inhibitors, JOURNAL OF VIROLOGY, Vol: 86, Pages: 203-213, ISSN: 0022-538X
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- Citations: 21
Dodding MP, Mitter R, Humphries AC, et al., 2011, A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome, EMBO JOURNAL, Vol: 30, Pages: 4523-4538, ISSN: 0261-4189
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- Citations: 72
Strunze S, Engelke MF, Wang I-H, et al., 2011, Kinesin-1-Mediated Capsid Disassembly and Disruption of the Nuclear Pore Complex Promote Virus Infection, CELL HOST & MICROBE, Vol: 10, Pages: 210-223, ISSN: 1931-3128
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- Citations: 142
Dodding MP, Way M, 2011, Coupling viruses to dynein and kinesin-1, EMBO JOURNAL, Vol: 30, Pages: 3527-3539, ISSN: 0261-4189
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- Citations: 161
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