I am a non-clinical lecturer in Physiology within the Section of Anaesthetics, Pain Medicine and Intensive Care. I received my PhD from Imperial College (St. Mary''s Hospital) in 1998 and following postdoctoral stints at King''s College London and Queen Mary University of London, rejoined Imperial in 2001.
I am a member of the Critical Care Research group headed by Prof Masao Takata, and have a major interest in understanding the science behind pulmonary aspects of critical care. In particular my main focus is the process by which the inflammatory response influences the development of acute lung injury within the Intensive Care unit. Areas of specific interest include -
- improved modelling
- mechanisms of ventilator-induced lung injury (VILI)
- TNF signaling during acute lung injury
- monocyte/macrophage involvement during VILI
I am Course Director for the BSc in Anaesthesia & Critical Care, and joint lead for the Anaesthetics, Pain Medicine and Intensive Care (APMIC) stream of the MRes in Biomedical Research.
- GlaxoSmithKline. 2008 -
- NeRRe therapeutics 2020-
et al., 2022, Microvesicle-mediated communication within the alveolar space: mechanisms of uptake by epithelial cells and alveolar macrophages, Frontiers in Immunology, Vol:13, ISSN:1664-3224
et al., 2022, Correction of a chronic pulmonary disease through lentiviral vector-mediated protein expression, Molecular Therapy - Methods and Clinical Development, ISSN:2329-0501
et al., 2021, Secreted extracellular cyclophilin a is a novel mediator of ventilator induced lung injury., American Journal of Respiratory and Critical Care Medicine, Vol:204, ISSN:1073-449X, Pages:421-430
et al., 2021, Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD, American Journal of Physiology: Lung Cellular and Molecular Physiology, Vol:320, ISSN:1040-0605, Pages:L73-L83
et al., 2021, Microvesicle-Mediated Enhancement of TNF-Driven Apoptosis During VILI, International Conference of the American-Thoracic-Society (ATS), AMER THORACIC SOC, ISSN:1073-449X