I am a non-clinical lecturer in Physiology within the Section of Anaesthetics, Pain Medicine and Intensive Care. I received my PhD from Imperial College (St. Mary''s Hospital) in 1998 and following postdoctoral stints at King''s College London and Queen Mary University of London, rejoined Imperial in 2001.
I am a member of the Critical Care Research group headed by Prof Masao Takata, and have a major interest in understanding the science behind pulmonary aspects of critical care. In particular my main focus is the process by which the inflammatory response influences the development of acute lung injury within the Intensive Care unit. Areas of specific interest include -
- improved modelling
- mechanisms of ventilator-induced lung injury (VILI)
- TNF signaling during acute lung injury
- monocyte/macrophage involvement during VILI
I am Course Director for the BSc in Anaesthesia & Critical Care, and joint lead for the Anaesthetics, Pain Medicine and Intensive Care (APMIC) stream of the MRes in Biomedical Research.
- GlaxoSmithKline. 2008 -
- NeRRe therapeutics 2020-
et al., 2022, Correction of a chronic pulmonary disease through lentiviral vector-mediated protein expression, Molecular Therapy - Methods and Clinical Development, Vol:25, ISSN:2329-0501, Pages:382-391
et al., 2022, Microvesicle-mediated communication within the alveolar space: mechanisms of uptake by epithelial cells and alveolar macrophages, Frontiers in Immunology, Vol:13, ISSN:1664-3224
et al., 2021, Secreted extracellular cyclophilin a is a novel mediator of ventilator induced lung injury., American Journal of Respiratory and Critical Care Medicine, Vol:204, ISSN:1073-449X, Pages:421-430
et al., 2022, Macrophage-Derived Microvesicles Induce Alveolar Epithelial Cell Death in an In Vitro Stretch Model, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, ISSN:1073-449X
et al., 2021, Microvesicle-Mediated Enhancement of TNF-Driven Apoptosis During VILI, International Conference of the American-Thoracic-Society (ATS), AMER THORACIC SOC, ISSN:1073-449X