Imperial College London
Alternate

Dr Mikaela Smit

Faculty of Medicine, School of Public Health

Honorary Research Fellow
 
 
 
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Contact

 

mikaela.smit

 
 
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Location

 

47 Praed StreetSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Davis:2020:10.1002/jia2.25616,
author = {Davis, K and Guzman, PP and Gregson, S and Smit, M},
doi = {10.1002/jia2.25616},
pages = {70--70},
publisher = {JOHN WILEY & SONS LTD},
title = {Comparing the prevalence of hypertension by HIV status in sub-Saharan African adults: a systematic review and meta-analyses of cross-sectional studies},
url = {http://dx.doi.org/10.1002/jia2.25616},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Background: Some evidence from high-income countries (HICs) suggests that PLHIV experience a higher hypertension prevalence thanHIV-negative individuals. It is unclear whether this is the case in subSaharan Africa (SSA), where large-scale integration of hypertensionservices into HIV programmes is being considered. We examined thehypothesis that living with HIV is associated with higher hypertensionprevalence among adults in SSA.Materials and methods: A systematic review of MEDLINE, EMBASE,Global Health, Cochrane Database of Systematic Reviews, CochraneCentral Register of Controlled Trials and African Journals Online wasperformed, following PRISMA guidelines, to identify cross-sectionalstudies assessing hypertension prevalence in PLHIV and HIV-negativeindividuals >15 years, in SSA. Only studies defining hypertension as“study-ascertained blood pressure ≥140/90 mmHg”, or as “studyascertained blood pressure ≥140/90 mmHg and/or history of antihypertensive medication usage”, were included. Risk of bias assessmentsaddressed adequacy of sample sizes, participant selection and HIV andhypertension status measurement. Random effects models were usedto pool odds ratios (ORs) for prevalent hypertension.Results: We identified 1431 unique studies, of which 12 wereselected for quantitative analysis, providing data on 107 425 participants (49.4% to 69.6% female). The 12 studies collected data between2003 and 2015, in South Africa, Tanzania and Uganda. Risk of biaswas low to moderate, with participant selection a key source of bias.Hypertension prevalence ranged from 5.3% to 51.7% among PLHIVand 8.2% to 65.4% in HIV-negative individuals. Overall, hypertensionprevalence was 41% lower among PLHIV than HIV-negative individuals when using the ≥140/90 mmHg definition (n = 5, OR 0.59, 95%CI 0.55 to 0.64) and 34% lower when using the definition thatincluded medication (n = 7, OR 0.66, 95% CI 0.47 to 0.99).Conclusions: Robust studies comparing hypertension
AU  - Davis,K
AU  - Guzman,PP
AU  - Gregson,S
AU  - Smit,M
DO  - 10.1002/jia2.25616
EP  - 70
PB  - JOHN WILEY & SONS LTD
PY  - 2020///
SP  - 70
TI  - Comparing the prevalence of hypertension by HIV status in sub-Saharan African adults: a systematic review and meta-analyses of cross-sectional studies
UR  - http://dx.doi.org/10.1002/jia2.25616
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000577152500101&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/87797
ER  -
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