Imperial College London
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PROFESSOR MIKE HUGHES

Faculty of Medicine, National Heart & Lung Institute

Honorary Professorial Research Fellow
 
 
 
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Contact

 

+44 (0)7909 726 742mike.hughes

 
 
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Location

 

Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Borland:2017:10.1016/j.resp.2017.02.010,
author = {Borland, C and Hughes, JMB and Guénard, H},
doi = {10.1016/j.resp.2017.02.010},
journal = {Respir Physiol Neurobiol},
pages = {53--57},
title = {The blood transfer conductance for CO and NO.},
url = {http://dx.doi.org/10.1016/j.resp.2017.02.010},
volume = {241},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Nitric oxide was introduced over 30 years ago as a test gas for alveolar capillary diffusion. As for CO its transfer has been interpreted according to the Roughton Forster relationship: 1/DL=1/DM+1/θVc. There has been disagreement, since the first measurements of DLNO, over whether θNO is infinite and thus DLNO=DMNO. There is overwhelming in vitro evidence that θNO is finite yet several groups (Coffman et al., 2017; Tamhane et al., 2001) use an infinite value in vivo. They also assume that DMNO is greater than twice DMCO, making DMCO less than that predicted by the physical laws of diffusion. Finally some (Coffman et al., 2017) recommend use of Reeve and Park's value for θCO (Reeves and Park, 1992; Coffman et al., 2017) rather than Forster's (Forster, 1987). Their grounds for doing so are that the combination of an infinite theta NO, an empirical value for DMNO/DMCO (>2.0) and Reeve and Park's θCO gives a value of DMCO (using a combined DLNO-DLCO analysis) which agrees with the DMCO value calculated separately by the classical two-stage oxygen technique of Roughton and Forster. In this paper we examine whether there are physiological reasons for assuming that DMNO is over twice DMCO in vivo. We are critical of Reeves and Park's estimate for the 1/θCO-PO2 relationship. We review in vitro estimates of θCO in the light of Guenard et al.'s recent in vivo estimate.
AU  - Borland,C
AU  - Hughes,JMB
AU  - Guénard,H
DO  - 10.1016/j.resp.2017.02.010
EP  - 57
PY  - 2017///
SP  - 53
TI  - The blood transfer conductance for CO and NO.
T2  - Respir Physiol Neurobiol
UR  - http://dx.doi.org/10.1016/j.resp.2017.02.010
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28259748
VL  - 241
ER  -
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