Imperial College London

DrMilesDalby

Faculty of MedicineNational Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

miles.dalby

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

149 results found

Kalogeras K, Jabbour RJ, Pracon R, Kabir T, Shannon J, Duncan A, Quarto C, Heng E-L, Rahbi H, Oikonomou E, Katsianos E, Patel N, Chandra N, Vavuranakis M-A, Cadiz S, Bougiakli M, Smith RD, Siasos G, Vavuranakis M, Davies S, Dalby M, Panoulas Vet al., 2023, Midterm Outcomes in Patients With Aortic Stenosis Treated With Contemporary Balloon-Expandable and Self-Expanding Valves: Does Valve Size Have an Impact on Outcome?, J Am Heart Assoc, Vol: 12

Background No data currently exist comparing the contemporary iterations of balloon-expandable (BE) Edwards SAPIEN 3/Ultra and the self-expanding (SE) Medtronic Evolut PRO/R34 valves. The aim of the study was the comparison of these transcatheter heart valves with emphasis on patients with small aortic annulus. Methods and Results In this retrospective registry, periprocedural outcomes and midterm all-cause mortality were analyzed. A total of 1673 patients (917 SE versus 756 BE) were followed up for a median of 15 months. A total of 194 patients died (11.6%) during follow-up. SE and BE groups showed similar survival at 1 (92.6% versus 90.6%) and 3 (80.3% versus 85.2%) years (Plog-rank=0.136). Compared with the BE group, patients treated with the SE device had lower peak (16.3±8 mm Hg SE versus 21.9±8 mm Hg BE) and mean (8.8±5 mm Hg SE versus 11.5±5 mm Hg BE) gradients at discharge. Conversely, the BE group demonstrated lower rates of at least moderate paravalvular regurgitation postoperatively (5.6% versus 0.7% for SE and BE valves, respectively; P<0.001). In patients treated with small transcatheter heart valves (≤26 mm for SE and ≤23 mm for BE; N=284 for SE and N=260 for BE), survival was higher among patients treated with SE valves at both 1 (96.7% SE versus 92.1% BE) and 3 (91.8% SE versus 82.2% BE) years (Plog-rank=0.042). In propensity-matched patients treated with small transcatheter heart valve, there remained a trend for higher survival among the SE group at both 1 (97% SE versus 92.3% BE) and 3 years (91.8% SE versus 78.7% BE), Plog-rank=0.096). Conclusions Real-world comparison of the latest-generation SE and BE devices demonstrated similar survival up to 3 years' follow-up. In patients with small transcatheter heart valves, there may be a trend for improved survival among those treated with SE valves.

Journal article

Pracon R, Dimitrov A, McGarvey M, Cadiz S, Kabir T, Dalby M, Duncan A, Davies SW, Panoulas Vet al., 2022, Outcomes of Patients Undergoing TAVI for Purely Regurgitant Native Aortic Valves With the Current Generation Transcatheter Aortic Valve Platforms, Publisher: ELSEVIER SCIENCE INC, Pages: B173-B174, ISSN: 0735-1097

Conference paper

Jabbour R, Pracon R, Kabir T, Shannon J, Duncan A, Heng EL, Oikonomou E, Katsianos E, Patel N, Chandra N, Smith R, Vavouranakis M, Dalby M, Panoulas V, Kalogeras Ket al., 2022, Improved Mid-term Survival in Aortic Stenosis Patients Treated With Small Self-Expanding vs Balloon- Expandable Transcatheter Heart Valves, Publisher: ELSEVIER SCIENCE INC, Pages: B186-B186, ISSN: 0735-1097

Conference paper

Pracon R, McGarvey M, Dimitrov A, Cadiz S, Kabir T, Dalby M, Duncan A, Davies SW, Panoulas Vet al., 2022, Outcomes of Patients Undergoing ViV TAVR With the Current-Generation Transcatheter Aortic Valves for Purely Regurgitant Surgical Bioprostheses, 34th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, Pages: B213-B213, ISSN: 0735-1097

Conference paper

Browne S, Smith D, Adams D, Thiruthalil S, McGovern I, Mattison S, Panoulas V, Kabir T, Davies S, Shannon J, Heng EL, Rahbi H, Chandra N, Patel N, Banya W, Tindale A, Smith R, Lane R, Dalby Met al., 2022, NURSE-LED SEDATION IS SAFE AND EFFECTIVE, SHORTENING PROCEDURE TIMES, AND IMPROVING ACCESS FOR SELECTED TRANSCATHETER AORTIC VALVE IMPLANTATION (TAVI) PATIENTS, Publisher: BMJ PUBLISHING GROUP, Pages: A56-A56, ISSN: 1355-6037

Conference paper

Sharma P, Thomas K, Rogers P, Prendergast C, Banya W, Lane R, Nolan C, Jones S, Canavan J, Kon S, Man W, Dalby Met al., 2022, 4-METRE-GAIT SPEED AS A PREDICTOR OF 5-YEAR SURVIVAL AFTER ACUTE MYOCARDIAL INFARCTION: A PROSPECTIVE COHORT STUDY, Annual Conference of the British-Cardiovascular-Society - 100 Years of Cardiology, Publisher: BMJ PUBLISHING GROUP, Pages: A43-A44, ISSN: 1355-6037

Conference paper

Toff WD, Hildick-Smith D, Kovac J, Mullen MJ, Wendler O, Mansouri A, Rombach I, Abrams KR, Conroy SP, Flather MD, Gray AM, MacCarthy P, Monaghan MJ, Prendergast B, Ray S, Young CP, Crossman DC, Cleland JGF, de Belder MA, Ludman PF, Jones S, Densem CG, Tsui S, Kuduvalli M, Mills JD, Banning AP, Sayeed R, Hasan R, Fraser DGW, Trivedi U, Davies SW, Duncan A, Curzen N, Ohri SK, Malkin CJ, Kaul P, Muir DF, Owens WA, Uren NG, Pessotto R, Kennon S, Awad W, Khogali SS, Matuszewski M, Edwards RJ, Ramesh BC, Dalby M, Raja SG, Mariscalco G, Lloyd C, Cox ID, Redwood SR, Gunning MG, Ridley PDet al., 2022, Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis A Randomized Clinical Trial, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 327, Pages: 1875-1887, ISSN: 0098-7484

Journal article

Kite TA, Banning AS, Ladwiniec A, Gale CP, Greenwood JP, Dalby M, Hobson R, Barber S, Parker E, Berry C, Flather MD, Curzen N, Banning AP, McCann GP, Gershlick AHet al., 2022, Very early invasive angiography versus standard of care in higher-risk non-ST elevation myocardial infarction: study protocol for the prospective multicentre randomised controlled RAPID N-STEMI trial, BMJ OPEN, Vol: 12, ISSN: 2044-6055

Journal article

Demir OM, Little CD, Jabbour R, Rahman H, Sayers M, Ahmed A, Connolly MJ, Kanyal R, MacCarthy P, Wilson SJ, Dalby M, Jain A, Malik I, Rakhit R, Perera Det al., 2021, Impact of COVID-19 pandemic on the management of nonculprit lesions in patients presenting with ST-elevation myocardial infarction: Outcomes from the pan-London heart attack centers, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 99, Pages: 391-396, ISSN: 1522-1946

Journal article

Kalogeras K, Zuhair M, Kabir T, Jabbour R, Dalby M, Ghada M, Shai S, Katsianos E, Iqbal M, Naganuma T, Davies S, Shannon J, Duncan A, Vavuranakis M, Panoulas Vet al., 2021, Real-world comparison of the last generation balloon-expandable and self-expanding valves in patients undergoing TAVI, ESC, Publisher: OXFORD UNIV PRESS, Pages: 2191-2191, ISSN: 0195-668X

Conference paper

Panoulas V, Rathod KS, Jain AK, Firoozi S, Nevett J, Kalra SS, Malik IS, Mathur A, Redwood S, MacCarthy PA, Wragg A, Jones DA, Dalby MCet al., 2021, Impact of Early (<= 24 h) Versus Delayed (> 24 h) Intervention in Patients With Non-ST Segment Elevation Myocardial Infarction: An Observational Study of 20,882 Patients From the London Heart Attack Group, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 22, Pages: 3-7, ISSN: 1553-8389

Journal article

Rathod KS, Jones DA, Jain AK, Lim P, MacCarthy PA, Rakhit R, Lockie T, Kalra S, Dalby MC, Malik IS, Whitbread M, Firoozi S, Bogle R, Redwood S, Cooper J, Gupta A, Lansky A, Wragg A, Mathur A, Ahluwalia Aet al., 2021, The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction, AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE, Vol: 11, Pages: 659-+, ISSN: 2160-200X

Journal article

Kalogeras K, Ruparelia N, Kabir T, Jabbour R, Kalantzis C, Bei E, Katsianos E, Naganuma T, Nakamura S, Sent S, Malik IS, Mikhail G, Dalby M, Vavuranakis M, Panoulas Vet al., 2020, Real-world comparison of the last generation main balloon-expandable and self-expanding valves in patients undergoing TAVI. Does the type matter?, European-Society-of-Cardiology (ESC) Congress, Publisher: OXFORD UNIV PRESS, Pages: 1953-1953, ISSN: 0195-668X

Conference paper

Rajakulasingam R, Nielles-Vallespin S, Ferreira PF, Scott AD, Khalique Z, Rogers P, Barnes G, Tindale A, Prendergast C, Cantor E, Wage R, Dalby M, Firmin DN, Pennell DJ, De Silva Ret al., 2020, Diffusion tensor cardiovascular magnetic resonance detects altered myocardial microstructure in patients with acute st-elevation myocardial infarction, European-Society-of-Cardiology (ESC) Congress, Publisher: OXFORD UNIV PRESS, Pages: 208-208, ISSN: 0195-668X

Conference paper

Kalogeras K, Ruparelia N, Kabir T, Jabbour R, Naganuma T, Vavuranakis M, Nakamura S, Wang B, Sen S, Hadjiloizou N, Malik IS, Mikhail G, Dalby M, Panoulas Vet al., 2020, Comparison of the self-expanding Evolut-PRO transcatheter aortic valve to its predecessor Evolut-R in the real world multicenter ATLAS registry, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 310, Pages: 120-125, ISSN: 0167-5273

Journal article

Rathod KS, Beirne A-M, Bogle R, Firoozi S, Lim P, Hill J, Dalby MC, Jain AK, Malik IS, Mathur A, Kalra SS, DeSilva R, Redwood S, MacCarthy PA, Wragg A, Smith EJ, Jones DAet al., 2020, Prior Coronary Artery Bypass Graft Surgery and Outcome After Percutaneous Coronary Intervention: An Observational Study From the Pan-London Percutaneous Coronary Intervention Registry, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 9

Journal article

Vela MM, Simon A, Gil FR, Rosenberg A, Dalby M, Kabir T, Saez DG, Panoulas Vet al., 2020, Clinical Indications of IMPELLA Short-Term Mechanical Circulatory Support in a Tertiary Centre, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 21, Pages: 629-637, ISSN: 1553-8389

Journal article

Rathod KS, Jain AK, Firoozi S, Lim P, Boyle R, Nevett J, Dalby MC, Kalra S, Malik IS, Sirker A, Mathur A, Redwood S, MacCarthy PA, Wragg A, Jones DAet al., 2020, Outcome of inter-hospital transfer versus direct admission for primary percutaneous coronary intervention: An observational study of 25,315 patients with ST-elevation myocardial infarction from the London Heart Attack Group, EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, Vol: 9, Pages: 948-957, ISSN: 2048-8726

Journal article

Rathod KS, Koganti S, Jain AK, Rakhit R, Dalby MC, Lockie T, Kalra S, Malik IS, Knight CJ, Whitbread M, Mathur A, Firoozi S, Bogle R, Redwood S, MacCarthy PA, Sirker A, O'Mahony C, Wragg A, Jones DAet al., 2020, Complete Versus Culprit only Revascularisation in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction: Incidence and Outcomes from the London Heart Attack Group, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 21, Pages: 350-358, ISSN: 1553-8389

Journal article

Little CD, Kotecha T, Candilio L, Jabbour RJ, Collins GB, Ahmed A, Connolly M, Kanyal R, Demir OM, Lawson LO, Wang B, Firoozi S, Spratt JC, Perera D, MacCarthy P, Dalby M, Jain A, Wilson SJ, Malik I, Rakhit Ret al., 2020, COVID-19 pandemic and STEMI: pathway activation and outcomes from the pan-London heart attack group, OPEN HEART, Vol: 7, ISSN: 2053-3624

Journal article

Gershlick AH, Banning AS, Parker E, Wang D, Budgeon CA, Kelly DJ, Kane PO, Dalby M, Hetherington SL, McCann GP, Greenwood JP, Curzen Net al., 2019, Long-Term Follow-Up of Complete Versus Lesion-Only Revascularization in STEMI and Multivessel Disease The CvLPRIT Trial, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 74, Pages: 3083-3094, ISSN: 0735-1097

Journal article

Dalby M, 2019, Christmas 2019 and New Year Greetings, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 3875-3878, ISSN: 0195-668X

Journal article

Dalby M, 2019, London Shock 19-Extending Options for Patients with Cardiogenic Shock, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 3875-3878, ISSN: 0195-668X

Journal article

Dowling C, Firoozi S, Panoulas V, Dalby M, Kashyap MN, Kabir T, Kalogeras K, Buch MH, Levy R, Chowdhary S, Saraf S, Roberts D, More R, Wiper A, Abdelaziz HK, Neylon A, Mylotte D, Pisaniello AD, Fraser DGW, Anderson R, Cunnington MS, Malkin CJ, Blackman DJ, Brennan PF, Owens CG, Manoharan G, Spence MS, Brecker SJet al., 2019, Initial experience of a self-expanding transcatheter aortic valve with an outer pericardial wrap: The United Kingdom and Ireland Implanters' registry, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 95, Pages: 1340-1346, ISSN: 1522-1946

Journal article

Panoulas VF, Ilsley CJ, Kalogeras K, Khan H, Vela MM, Dalby M, Kabir T, Smith RD, Mason M, Grocott-Mason R, Cummings I, Luscher TF, Raja SGet al., 2019, Coronary artery bypass confers intermediate-term survival benefit over percutaneous coronary intervention with new-generation stents in real-world patients with multivessel coronary artery disease, including left main disease: a retrospective analysis of 6383 patients, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 56, Pages: 911-918, ISSN: 1010-7940

Journal article

Kalogeras K, Jabbour RJ, Ruparelia N, Watson S, Kabir T, Naganuma T, Vavuranakis M, Nakamura S, Malik IS, Mikhail G, Dalby M, Panoulas Vet al., 2019, Comparison of warfarin versus DOACs in patients with concomitant indication for oral anticoagulation undergoing TAVI; results from the ATLAS registry, JOURNAL OF THROMBOSIS AND THROMBOLYSIS, Vol: 50, Pages: 82-89, ISSN: 0929-5305

Journal article

Beirne A, Rathod K, Jain A, Mathur A, Wragg A, Smith EJ, Jones DA, Kalra S, Malik I, Redwood S, MacCarthy P, Bogle R, Firoozi S, Dalby Met al., 2019, The association between prior coronary artery bypass graft surgery and outcome after percutaneous coronary intervention (PCI): an observational study of 123,780 patients, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 4112-4112, ISSN: 0195-668X

Conference paper

Mittal TK, Reichmuth L, Bhattacharyya S, Jain M, Baltabaeva A, Haley SR, Mirsadraee S, Panoulas V, Kabir T, Nicol ED, Dalby M, Long Qet al., 2019, Inconsistency in aortic stenosis severity between CT and echocardiography: prevalence and insights into mechanistic differences using computational fluid dynamics, Open Heart, Vol: 6, ISSN: 2053-3624

Objectives The aims of this study were to evaluate the inconsistency of aortic stenosis (AS) severity between CT aortic valve area (CT-AVA) and echocardiographic Doppler parameters, and to investigate potential underlying mechanisms using computational fluid dynamics (CFD).Methods A total of 450 consecutive eligible patients undergoing transcatheter AV implantation assessment underwent CT cardiac angiography (CTCA) following echocardiography. CT-AVA derived by direct planimetry and echocardiographic parameters were used to assess severity. CFD simulation was performed in 46 CTCA cases to evaluate velocity profiles.Results A CT-AVA>1 cm2 was present in 23% of patients with echocardiographic peak velocity≥4 m/s (r=−0.33) and in 15% patients with mean Doppler gradient≥40 mm Hg (r=−0.39). Patients with inconsistent severity grading between CT and echocardiography had higher stroke volume index (43 vs 38 mL/m2, p<0.003) and left ventricular outflow tract (LVOT) flow rate (235 vs 192 cm3/s, p<0.001). CFD simulation revealed high flow, either in isolation (p=0.01), or when associated with a skewed velocity profile (p=0.007), as the main cause for inconsistency between CT and echocardiography.Conclusion Severe AS by Doppler criteria may be associated with a CT-AVA>1 cm2 in up to a quarter of patients. CFD demonstrates that haemodynamic severity may be exaggerated on Doppler analysis due to high LVOT flow rates, with or without skewed velocity profiles, across the valve orifice. These factors should be considered before making a firm diagnosis of severe AS and evaluation with CT can be helpful.

Journal article

Jones DA, Rathod KS, Koganti S, Lim P, Firoozi S, Bogle R, Jain AK, MacCarthy PA, Dalby MC, Malik IS, Mathur A, DeSilva R, Rakhit R, Kalra SS, Redwood S, Ludman P, Wragg Aet al., 2019, The association between the public reporting of individual operator outcomes with patient profiles, procedural management, and mortality after percutaneous coronary intervention: an observational study from the Pan-London PCI (BCIS) Registry using an interrupted time series analysis, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 2620-2629, ISSN: 0195-668X

Journal article

Dowling C, Firoozi S, Doyle N, Blackman DJ, Malkin CJ, Cunnington MS, Saraf S, Buch MH, Levy R, Chowdhary S, Spence MS, Manoharan G, Owens CG, Brennan PF, Roberts D, More R, Wiper A, Abdelaziz HK, Mylotte D, Neylon A, Martin N, Mercanti F, Dorman S, Panoulas V, Dalby M, Kashyap MN, Kabir T, Kovac J, Kontoprias K, Malik IS, Ghada MW, Sen S, Ruparelia N, Demir OM, Frame A, Uren NG, Anderson R, Rajathurai T, Tapp L, Deegan L, Grech E, Hall I, Neville M, Rampat R, Hildick-Smith D, Mullen M, Kennon S, Chandrala P, Doshi S, Brecker SJet al., 2019, Initial experience of a large, self-expanding, and fully recapturable transcatheter aortic valve: The UK & Ireland Implanters' registry, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 93, Pages: 751-757, ISSN: 1522-1946

Journal article

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