Imperial College London

DrMilesDalby

Faculty of MedicineNational Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

miles.dalby

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
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139 results found

Panoulas V, Rathod KS, Jain AK, Firoozi S, Nevett J, Kalra SS, Malik IS, Mathur A, Redwood S, MacCarthy PA, Wragg A, Jones DA, Dalby MCet al., 2021, Impact of Early (<= 24 h) Versus Delayed (> 24 h) Intervention in Patients With Non-ST Segment Elevation Myocardial Infarction: An Observational Study of 20,882 Patients From the London Heart Attack Group, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 22, Pages: 3-7, ISSN: 1553-8389

Journal article

Kalogeras K, Ruparelia N, Kabir T, Jabbour R, Kalantzis C, Bei E, Katsianos E, Naganuma T, Nakamura S, Sent S, Malik IS, Mikhail G, Dalby M, Vavuranakis M, Panoulas Vet al., 2020, Real-world comparison of the last generation main balloon-expandable and self-expanding valves in patients undergoing TAVI. Does the type matter?, Publisher: OXFORD UNIV PRESS, Pages: 1953-1953, ISSN: 0195-668X

Conference paper

Rajakulasingam R, Nielles-Vallespin S, Ferreira PF, Scott AD, Khalique Z, Rogers P, Barnes G, Tindale A, Prendergast C, Cantor E, Wage R, Dalby M, Firmin DN, Pennell DJ, De Silva Ret al., 2020, Diffusion tensor cardiovascular magnetic resonance detects altered myocardial microstructure in patients with acute st-elevation myocardial infarction, Publisher: OXFORD UNIV PRESS, Pages: 208-208, ISSN: 0195-668X

Conference paper

Kalogeras K, Ruparelia N, Kabir T, Jabbour R, Naganuma T, Vavuranakis M, Nakamura S, Wang B, Sen S, Hadjiloizou N, Malik IS, Mikhail G, Dalby M, Panoulas Vet al., 2020, Comparison of the self-expanding Evolut-PRO transcatheter aortic valve to its predecessor Evolut-R in the real world multicenter ATLAS registry, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 310, Pages: 120-125, ISSN: 0167-5273

Journal article

Rathod KS, Beirne A-M, Bogle R, Firoozi S, Lim P, Hill J, Dalby MC, Jain AK, Malik IS, Mathur A, Kalra SS, DeSilva R, Redwood S, MacCarthy PA, Wragg A, Smith EJ, Jones DAet al., 2020, Prior Coronary Artery Bypass Graft Surgery and Outcome After Percutaneous Coronary Intervention: An Observational Study From the Pan-London Percutaneous Coronary Intervention Registry, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 9, ISSN: 2047-9980

Journal article

Vela MM, Simon A, Gil FR, Rosenberg A, Dalby M, Kabir T, Saez DG, Panoulas Vet al., 2020, Clinical Indications of IMPELLA Short-Term Mechanical Circulatory Support in a Tertiary Centre, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 21, Pages: 629-637, ISSN: 1553-8389

Journal article

Rathod KS, Jain AK, Firoozi S, Lim P, Boyle R, Nevett J, Dalby MC, Kalra S, Malik IS, Sirker A, Mathur A, Redwood S, MacCarthy PA, Wragg A, Jones DAet al., 2020, Outcome of inter-hospital transfer versus direct admission for primary percutaneous coronary intervention: An observational study of 25,315 patients with ST-elevation myocardial infarction from the London Heart Attack Group, EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, Vol: 9, Pages: 948-957, ISSN: 2048-8726

Journal article

Rathod KS, Koganti S, Jain AK, Rakhit R, Dalby MC, Lockie T, Kalra S, Malik IS, Knight CJ, Whitbread M, Mathur A, Firoozi S, Bogle R, Redwood S, MacCarthy PA, Sirker A, O'Mahony C, Wragg A, Jones DAet al., 2020, Complete Versus Culprit only Revascularisation in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction: Incidence and Outcomes from the London Heart Attack Group, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 21, Pages: 350-358, ISSN: 1553-8389

Journal article

Little CD, Kotecha T, Candilio L, Jabbour RJ, Collins GB, Ahmed A, Connolly M, Kanyal R, Demir OM, Lawson LO, Wang B, Firoozi S, Spratt JC, Perera D, MacCarthy P, Dalby M, Jain A, Wilson SJ, Malik I, Rakhit Ret al., 2020, COVID-19 pandemic and STEMI: pathway activation and outcomes from the pan-London heart attack group, OPEN HEART, Vol: 7, ISSN: 2053-3624

Journal article

Gershlick AH, Banning AS, Parker E, Wang D, Budgeon CA, Kelly DJ, Kane PO, Dalby M, Hetherington SL, McCann GP, Greenwood JP, Curzen Net al., 2019, Long-Term Follow-Up of Complete Versus Lesion-Only Revascularization in STEMI and Multivessel Disease The CvLPRIT Trial, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 74, Pages: 3083-3094, ISSN: 0735-1097

Journal article

Dalby M, 2019, Christmas 2019 and New Year Greetings, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 3875-3878, ISSN: 0195-668X

Journal article

Dalby M, 2019, London Shock 19-Extending Options for Patients with Cardiogenic Shock, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 3875-3878, ISSN: 0195-668X

Journal article

Dowling C, Firoozi S, Panoulas V, Dalby M, Kashyap MN, Kabir T, Kalogeras K, Buch MH, Levy R, Chowdhary S, Saraf S, Roberts D, More R, Wiper A, Abdelaziz HK, Neylon A, Mylotte D, Pisaniello AD, Fraser DGW, Anderson R, Cunnington MS, Malkin CJ, Blackman DJ, Brennan PF, Owens CG, Manoharan G, Spence MS, Brecker SJet al., 2019, Initial experience of a self-expanding transcatheter aortic valve with an outer pericardial wrap: The United Kingdom and Ireland Implanters' registry, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 95, Pages: 1340-1346, ISSN: 1522-1946

Journal article

Panoulas VF, Ilsley CJ, Kalogeras K, Khan H, Vela MM, Dalby M, Kabir T, Smith RD, Mason M, Grocott-Mason R, Cummings I, Luscher TF, Raja SGet al., 2019, Coronary artery bypass confers intermediate-term survival benefit over percutaneous coronary intervention with new-generation stents in real-world patients with multivessel coronary artery disease, including left main disease: a retrospective analysis of 6383 patients, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 56, Pages: 911-918, ISSN: 1010-7940

Journal article

Kalogeras K, Jabbour RJ, Ruparelia N, Watson S, Kabir T, Naganuma T, Vavuranakis M, Nakamura S, Malik IS, Mikhail G, Dalby M, Panoulas Vet al., 2019, Comparison of warfarin versus DOACs in patients with concomitant indication for oral anticoagulation undergoing TAVI; results from the ATLAS registry, JOURNAL OF THROMBOSIS AND THROMBOLYSIS, Vol: 50, Pages: 82-89, ISSN: 0929-5305

Journal article

Beirne A, Rathod K, Jain A, Mathur A, Wragg A, Smith EJ, Jones DA, Kalra S, Malik I, Redwood S, MacCarthy P, Bogle R, Firoozi S, Dalby Met al., 2019, The association between prior coronary artery bypass graft surgery and outcome after percutaneous coronary intervention (PCI): an observational study of 123,780 patients, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 4112-4112, ISSN: 0195-668X

Conference paper

Mittal TK, Reichmuth L, Bhattacharyya S, Jain M, Baltabaeva A, Haley SR, Mirsadraee S, Panoulas V, Kabir T, Nicol ED, Dalby M, Long Qet al., 2019, Inconsistency in aortic stenosis severity between CT and echocardiography: prevalence and insights into mechanistic differences using computational fluid dynamics, Open Heart, Vol: 6, ISSN: 2053-3624

Objectives The aims of this study were to evaluate the inconsistency of aortic stenosis (AS) severity between CT aortic valve area (CT-AVA) and echocardiographic Doppler parameters, and to investigate potential underlying mechanisms using computational fluid dynamics (CFD).Methods A total of 450 consecutive eligible patients undergoing transcatheter AV implantation assessment underwent CT cardiac angiography (CTCA) following echocardiography. CT-AVA derived by direct planimetry and echocardiographic parameters were used to assess severity. CFD simulation was performed in 46 CTCA cases to evaluate velocity profiles.Results A CT-AVA>1 cm2 was present in 23% of patients with echocardiographic peak velocity≥4 m/s (r=−0.33) and in 15% patients with mean Doppler gradient≥40 mm Hg (r=−0.39). Patients with inconsistent severity grading between CT and echocardiography had higher stroke volume index (43 vs 38 mL/m2, p<0.003) and left ventricular outflow tract (LVOT) flow rate (235 vs 192 cm3/s, p<0.001). CFD simulation revealed high flow, either in isolation (p=0.01), or when associated with a skewed velocity profile (p=0.007), as the main cause for inconsistency between CT and echocardiography.Conclusion Severe AS by Doppler criteria may be associated with a CT-AVA>1 cm2 in up to a quarter of patients. CFD demonstrates that haemodynamic severity may be exaggerated on Doppler analysis due to high LVOT flow rates, with or without skewed velocity profiles, across the valve orifice. These factors should be considered before making a firm diagnosis of severe AS and evaluation with CT can be helpful.

Journal article

Jones DA, Rathod KS, Koganti S, Lim P, Firoozi S, Bogle R, Jain AK, MacCarthy PA, Dalby MC, Malik IS, Mathur A, DeSilva R, Rakhit R, Kalra SS, Redwood S, Ludman P, Wragg Aet al., 2019, The association between the public reporting of individual operator outcomes with patient profiles, procedural management, and mortality after percutaneous coronary intervention: an observational study from the Pan-London PCI (BCIS) Registry using an interrupted time series analysis, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 2620-2629, ISSN: 0195-668X

Journal article

Dowling C, Firoozi S, Doyle N, Blackman DJ, Malkin CJ, Cunnington MS, Saraf S, Buch MH, Levy R, Chowdhary S, Spence MS, Manoharan G, Owens CG, Brennan PF, Roberts D, More R, Wiper A, Abdelaziz HK, Mylotte D, Neylon A, Martin N, Mercanti F, Dorman S, Panoulas V, Dalby M, Kashyap MN, Kabir T, Kovac J, Kontoprias K, Malik IS, Ghada MW, Sen S, Ruparelia N, Demir OM, Frame A, Uren NG, Anderson R, Rajathurai T, Tapp L, Deegan L, Grech E, Hall I, Neville M, Rampat R, Hildick-Smith D, Mullen M, Kennon S, Chandrala P, Doshi S, Brecker SJet al., 2019, Initial experience of a large, self-expanding, and fully recapturable transcatheter aortic valve: The UK & Ireland Implanters' registry, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 93, Pages: 751-757, ISSN: 1522-1946

Journal article

Kalogeras K, Kabir T, Mittal T, Mirsadraee S, Skondras E, Haley SR, Zuhair M, Vavuranakis M, Tousoulis D, Dalby M, Panoulas Vet al., 2019, Real-world comparison of the new 34 mm self-expandable transcatheter aortic prosthesis Evolut R to its 31 mm core valve predecessor, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 93, Pages: 685-691, ISSN: 1522-1946

Journal article

Rathod KS, Koganti S, Jain AK, Astroulakis Z, Lim P, Rakhit R, Kalra SS, Dalby MC, O'Mahony C, Malik IS, Knight CJ, Mathur A, Redwood S, Sirker A, MacCarthy PA, Smith EJ, Wragg A, Jones DAet al., 2018, Complete Versus Culprit-Only Lesion Intervention in Patients With Acute Coronary Syndromes, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 72, Pages: 1989-1999, ISSN: 0735-1097

Journal article

Patterson T, Perkins A, Perkins GD, Clayton T, Evans R, Nguyen H, Wilson K, Whitbread M, Hughes J, Fothergill RT, Nevett J, Mosweu I, McCrone P, Dalby M, Rakhit R, MacCarthy P, Perera D, Nolan JP, Redwood SRet al., 2018, Rationale and design of: A Randomized tRial of Expedited transfer to a cardiac arrest center for non-ST elevation out-of-hospital cardiac arrest: The ARREST randomized controlled trial, AMERICAN HEART JOURNAL, Vol: 204, Pages: 92-101, ISSN: 0002-8703

Journal article

Broyd CJ, Panoulas V, Mattar W, Akhtar M, Shekarchi-Khanghahi E, Ioannou A, Raja SG, Mason M, Rahman-Haley S, Skondras E, Dalby M, Luscher TF, Kabir Tet al., 2018, Effect of Aortic Valve Calcium Quantity on Outcome After Balloon Aortic Valvuloplasty for Severe Aortic Stenosis, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 122, Pages: 1036-1041, ISSN: 0002-9149

Journal article

Rogers P, Banya W, Kabir T, Panoulas V, Probert H, Prendergast C, Taylor R, Dalby Met al., 2018, Does cardiac rehabilitation improve functional, independence, frailty and emotional outcomes following trans catheter aortic valve replacement?, European-Society-of-Cardiology Congress, Publisher: OXFORD UNIV PRESS, Pages: 1121-1121, ISSN: 0195-668X

Conference paper

Jones DA, Rathod KS, Koganti S, Hamshere S, Astroulakis Z, Lim P, Sirker A, O'Mahony C, Jain AK, Knight CJ, Dalby MC, Malik IS, Mathur A, Rakhit R, Lockie T, Redwood S, MacCarthy PA, Desilva R, Weerackody R, Wragg A, Smith EJ, Bourantas CVet al., 2018, Angiography alone versus angiography plus optical coherence tomography to guide percutaneous coronary intervention: outcomes from the pan-London PCI cohort, JACC: Cardiovascular Interventions, Vol: 11, Pages: 1313-1321, ISSN: 1936-8798

OBJECTIVES: This study aimed to determine the effect on long-term survival of using optical coherence tomography (OCT) during percutaneous coronary intervention (PCI). BACKGROUND: Angiographic guidance for PCI has substantial limitations. The superior spatial resolution of OCT could translate into meaningful clinical benefits, although limited data exist to date about their effect on clinical endpoints. METHODS: This was a cohort study based on the Pan-London (United Kingdom) PCI registry, which includes 123,764 patients who underwent PCI in National Health Service hospitals in London between 2005 and 2015. Patients undergoing primary PCI or pressure wire use were excluded leaving 87,166 patients in the study. The primary endpoint was all-cause mortality at a median of 4.8 years. RESULTS: OCT was used in 1,149 (1.3%) patients, intravascular ultrasound (IVUS) was used in 10,971 (12.6%) patients, and angiography alone in the remaining 75,046 patients. Overall OCT rates increased over time (p < 0.0001), with variation in rates between centers (p = 0.002). The mean stent length was shortest in the angiography-guided group, longer in the IVUS-guided group, and longest in the OCT-guided group. OCT-guided procedures were associated with greater procedural success rates and reduced in-hospital MACE rates. A significant difference in mortality was observed between patients who underwent OCT-guided PCI (7.7%) compared with patients who underwent either IVUS-guided (12.2%) or angiography-guided (15.7%; p < 0.0001) PCI, with differences seen for both elective (p < 0.0001) and acute coronary syndrome subgroups (p = 0.0024). Overall this difference persisted after multivariate Cox analysis (hazard ratio [HR]: 0.48; 95% confidence interval [CI]: 0.26 to 0.81; p = 0.001) and propensity matching (hazard ratio: 0.39; 95% CI: 0.21 to 0.77; p = 0.0008; OCT vs. angiography-alone cohort), with no difference in matched OCT and IVUS cohorts

Journal article

Jones DA, Rathod KS, Pavlidis AN, Gallagher SM, Astroulakis Z, Lim P, Sirker A, Knight CJ, Dalby MC, Malik IS, Mathur A, Rakhit R, Redwood S, MacCarthy PA, Baker C, Desilva R, Di Mario C, Weerackody R, Hill J, Wragg A, Smith EJet al., 2018, Outcomes after chronic total occlusion percutaneous coronary interventions: an observational study of 5496 patients from the Pan-London CTO Cohort., Coron Artery Dis

BACKGROUND: Chronic total occlusions (CTO) are commonly encountered in patients undergoing coronary angiography; however, percutaneous coronary intervention (PCI) is infrequently performed owing to technical difficulty, the perceived risk of complications and a lack of randomized data. The aim of this study was to analyse the frequency and outcomes of CTO-PCI procedures in a large contemporary cohort of successive patients. PATIENTS AND METHODS: We undertook an observational cohort study of 48 234 patients with stable angina of which 5496 (11.4%) procedures were performed for CTOs between 2005 and 2015 at nine tertiary cardiac centres across London, UK. Outcome was assessed by in-hospital major adverse cardiac events and all-cause mortality at a median follow-up of 4.8 years (interquartile range: 2.2-6.4 years). RESULTS: Over time, there was an increase in the proportion of elective PCI procedures performed for CTOs, but no increase in the absolute number. Overall success rates increased over time (74.3% in 2005 to 81.5% in 2015; P=0.0003) despite an increase in case complexity (previous myocardial infarction, diabetes, renal failure, previous coronary artery bypass grafting, peripheral vascular disease and left ventricular impairment) that correlated with procedural advancements. Successful CTO PCI was associated with lower mortality [9.5%, 95% confidence interval (CI): 8.1-11.6 vs. 15.3%, 95% CI: 13.7-20.6, P<0.0001] that persisted after multivariate cox analysis (hazard ratio: 0.37, 95% CI: 0.25-0.62) and propensity matching (hazard ratio=0.36, 95% CI: 0.18-0.73, P=0.0005). CONCLUSION: Successful procedures were associated with lower mortality suggesting that the greater uptake of CTO PCI may improve clinical outcomes in a wider population than are currently being offered therapy.

Journal article

Iqbal MB, Smith RD, Lane R, Patel N, Mattar W, Kabir T, Panoulas V, Mason M, Dalby MC, Grocott-Mason R, Ilsley CDet al., 2018, The prognostic significance of incomplete revascularization and untreated coronary anatomy following percutaneous coronary intervention: An analysis of 6,755 patients with multivessel disease, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 91, Pages: 1229-1239, ISSN: 1522-1946

Journal article

Dalby M, 2018, State of the art in TAVI, EUROPEAN HEART JOURNAL, Vol: 39, Pages: 1878-1881, ISSN: 0195-668X

Journal article

Mittal T, Nicol E, Reichmuth L, Jain M, Baltabaeva A, Rahman-Haley S, Kabir T, Panoulas V, Mirsadraee S, Dalby M, Long Qet al., 2018, INFLUENCE OF FLOW AND VELOCITY PROFILE ON INCONSISTENCY IN ECHOCARDIOGRAPHIC AORTIC VALVE STENOSIS ASSESSMENT: A COMPUTED TOMOGRAPHY AND COMPUTATIONAL FLOW DYNAMICS STUDY, 67th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), Publisher: ELSEVIER SCIENCE INC, Pages: 1583-1583, ISSN: 0735-1097

Conference paper

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