Publications
151 results found
Patterson T, Perkins GD, Perkins A, et al., 2023, Expedited transfer to a cardiac arrest centre for non-ST-elevation out-of-hospital cardiac arrest (ARREST): a UK prospective, multicentre, parallel, randomised clinical trial., Lancet, Vol: 402, Pages: 1329-1337
BACKGROUND: The International Liaison Committee on Resuscitation has called for a randomised trial of delivery to a cardiac arrest centre. We aimed to assess whether expedited delivery to a cardiac arrest centre compared with current standard of care following resuscitated cardiac arrest reduces deaths. METHODS: ARREST is a prospective, parallel, multicentre, open-label, randomised superiority trial. Patients (aged ≥18 years) with return of spontaneous circulation following out-of-hospital cardiac arrest without ST elevation were randomly assigned (1:1) at the scene of their cardiac arrest by London Ambulance Service staff using a secure online randomisation system to expedited delivery to the cardiac catheter laboratory at one of seven cardiac arrest centres or standard of care with delivery to the geographically closest emergency department at one of 32 hospitals in London, UK. Masking of the ambulance staff who delivered the interventions and those reporting treatment outcomes in hospital was not possible. The primary outcome was all-cause mortality at 30 days, analysed in the intention-to-treat (ITT) population excluding those with unknown mortality status. Safety outcomes were analysed in the ITT population. The trial was prospectively registered with the International Standard Randomised Controlled Trials Registry, 96585404. FINDINGS: Between Jan 15, 2018, and Dec 1, 2022, 862 patients were enrolled, of whom 431 (50%) were randomly assigned to a cardiac arrest centre and 431 (50%) to standard care. 20 participants withdrew from the cardiac arrest centre group and 19 from the standard care group, due to lack of consent or unknown mortality status, leaving 411 participants in the cardiac arrest centre group and 412 in the standard care group for the primary analysis. Of 822 participants for whom data were available, 560 (68%) were male and 262 (32%) were female. The primary endpoint of 30-day mortality occurred in 258 (63%) of 411 participants in the cardiac
Hewitson LJ, Cadiz S, Al-Sayed S, et al., 2023, Time to TAVI: streamlining the pathway to treatment, OPEN HEART, Vol: 10, ISSN: 2053-3624
Kalogeras K, Jabbour RJ, Pracon R, et al., 2023, Midterm Outcomes in Patients With Aortic Stenosis Treated With Contemporary Balloon-Expandable and Self-Expanding Valves: Does Valve Size Have an Impact on Outcome?, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 12
Pracon R, McGarvey M, Dimitrov A, et al., 2022, Outcomes of Patients Undergoing ViV TAVR With the Current-Generation Transcatheter Aortic Valves for Purely Regurgitant Surgical Bioprostheses, 34th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, Pages: B213-B213, ISSN: 0735-1097
Jabbour R, Pracon R, Kabir T, et al., 2022, Improved Mid-term Survival in Aortic Stenosis Patients Treated With Small Self-Expanding vs Balloon- Expandable Transcatheter Heart Valves, 34th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, Pages: B186-B186, ISSN: 0735-1097
Pracon R, Dimitrov A, McGarvey M, et al., 2022, Outcomes of Patients Undergoing TAVI for Purely Regurgitant Native Aortic Valves With the Current Generation Transcatheter Aortic Valve Platforms, 34th Annual Symposium on Transcatheter Cardiovascular Therapeutics (TCT), Publisher: ELSEVIER SCIENCE INC, Pages: B173-B174, ISSN: 0735-1097
Browne S, Smith D, Adams D, et al., 2022, NURSE-LED SEDATION IS SAFE AND EFFECTIVE, SHORTENING PROCEDURE TIMES, AND IMPROVING ACCESS FOR SELECTED TRANSCATHETER AORTIC VALVE IMPLANTATION (TAVI) PATIENTS, Publisher: BMJ PUBLISHING GROUP, Pages: A56-A56, ISSN: 1355-6037
Sharma P, Thomas K, Rogers P, et al., 2022, 4-METRE-GAIT SPEED AS A PREDICTOR OF 5-YEAR SURVIVAL AFTER ACUTE MYOCARDIAL INFARCTION: A PROSPECTIVE COHORT STUDY, Annual Conference of the British-Cardiovascular-Society - 100 Years of Cardiology, Publisher: BMJ PUBLISHING GROUP, Pages: A43-A44, ISSN: 1355-6037
Toff WD, Hildick-Smith D, Kovac J, et al., 2022, Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis A Randomized Clinical Trial, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 327, Pages: 1875-1887, ISSN: 0098-7484
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- Citations: 29
Kite TA, Banning AS, Ladwiniec A, et al., 2022, Very early invasive angiography versus standard of care in higher-risk non-ST elevation myocardial infarction: study protocol for the prospective multicentre randomised controlled RAPID N-STEMI trial, BMJ OPEN, Vol: 12, ISSN: 2044-6055
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- Citations: 1
Demir OM, Little CD, Jabbour R, et al., 2022, Impact of COVID-19 pandemic on the management of nonculprit lesions in patients presenting with ST-elevation myocardial infarction: Outcomes from the pan-London heart attack centers, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 99, Pages: 391-396, ISSN: 1522-1946
Kalogeras K, Zuhair M, Kabir T, et al., 2021, Real-world comparison of the last generation balloon-expandable and self-expanding valves in patients undergoing TAVI, ESC, Publisher: OXFORD UNIV PRESS, Pages: 2191-2191, ISSN: 0195-668X
Panoulas V, Rathod KS, Jain AK, et al., 2021, Impact of Early (≤24 h) Versus Delayed (>24 h) Intervention in Patients With Non-ST Segment Elevation Myocardial Infarction: An Observational Study of 20,882 Patients From the London Heart Attack Group, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 22, Pages: 3-7, ISSN: 1553-8389
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- Citations: 3
Rathod KS, Jones DA, Jain AK, et al., 2021, The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction, AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE, Vol: 11, Pages: 659-+, ISSN: 2160-200X
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- Citations: 3
Rathod KS, Jain AK, Firoozi S, et al., 2020, Outcome of inter-hospital transfer versus direct admission for primary percutaneous coronary intervention: An observational study of 25,315 patients with ST-elevation myocardial infarction from the London Heart Attack Group, EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, Vol: 9, Pages: 948-957, ISSN: 2048-8726
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- Citations: 15
Kalogeras K, Ruparelia N, Kabir T, et al., 2020, Real-world comparison of the last generation main balloon-expandable and self-expanding valves in patients undergoing TAVI. Does the type matter?, European-Society-of-Cardiology (ESC) Congress, Publisher: OXFORD UNIV PRESS, Pages: 1953-1953, ISSN: 0195-668X
Rajakulasingam R, Nielles-Vallespin S, Ferreira PF, et al., 2020, Diffusion tensor cardiovascular magnetic resonance detects altered myocardial microstructure in patients with acute st-elevation myocardial infarction, European-Society-of-Cardiology (ESC) Congress, Publisher: OXFORD UNIV PRESS, Pages: 208-208, ISSN: 0195-668X
Kalogeras K, Ruparelia N, Kabir T, et al., 2020, Comparison of the self-expanding Evolut-PRO transcatheter aortic valve to its predecessor Evolut-R in the real world multicenter ATLAS registry, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 310, Pages: 120-125, ISSN: 0167-5273
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- Citations: 15
Kalogeras K, Jabbour RJ, Ruparelia N, et al., 2020, Comparison of warfarin versus DOACs in patients with concomitant indication for oral anticoagulation undergoing TAVI; results from the ATLAS registry, JOURNAL OF THROMBOSIS AND THROMBOLYSIS, Vol: 50, Pages: 82-89, ISSN: 0929-5305
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- Citations: 18
Rathod KS, Beirne A-M, Bogle R, et al., 2020, Prior Coronary Artery Bypass Graft Surgery and Outcome After Percutaneous Coronary Intervention: An Observational Study From the Pan-London Percutaneous Coronary Intervention Registry, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 9
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- Citations: 14
Dowling C, Firoozi S, Panoulas V, et al., 2020, Initial experience of a self-expanding transcatheter aortic valve with an outer pericardial wrap: The United Kingdom and Ireland Implanters' registry, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 95, Pages: 1340-1346, ISSN: 1522-1946
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- Citations: 6
Vela MM, Simon A, Gil FR, et al., 2020, Clinical Indications of IMPELLA Short-Term Mechanical Circulatory Support in a Tertiary Centre, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 21, Pages: 629-637, ISSN: 1553-8389
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- Citations: 15
Rathod KS, Koganti S, Jain AK, et al., 2020, Complete Versus Culprit only Revascularisation in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction: Incidence and Outcomes from the London Heart Attack Group, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 21, Pages: 350-358, ISSN: 1553-8389
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- Citations: 4
Little CD, Kotecha T, Candilio L, et al., 2020, COVID-19 pandemic and STEMI: pathway activation and outcomes from the pan-London heart attack group, OPEN HEART, Vol: 7, ISSN: 2053-3624
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- Citations: 20
Gershlick AH, Banning AS, Parker E, et al., 2019, Long-Term Follow-Up of Complete Versus Lesion-Only Revascularization in STEMI and Multivessel Disease The CvLPRIT Trial, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 74, Pages: 3083-3094, ISSN: 0735-1097
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- Citations: 30
Dalby M, 2019, Christmas 2019 and New Year Greetings, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 3875-3878, ISSN: 0195-668X
Dalby M, 2019, London Shock 19-Extending Options for Patients with Cardiogenic Shock, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 3875-3878, ISSN: 0195-668X
Panoulas VF, Ilsley CJ, Kalogeras K, et al., 2019, Coronary artery bypass confers intermediate-term survival benefit over percutaneous coronary intervention with new-generation stents in real-world patients with multivessel coronary artery disease, including left main disease: a retrospective analysis of 6383 patients, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 56, Pages: 911-918, ISSN: 1010-7940
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- Citations: 4
Beirne A, Rathod K, Jain A, et al., 2019, The association between prior coronary artery bypass graft surgery and outcome after percutaneous coronary intervention (PCI): an observational study of 123,780 patients, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 4112-4112, ISSN: 0195-668X
Mittal TK, Reichmuth L, Bhattacharyya S, et al., 2019, Inconsistency in aortic stenosis severity between CT and echocardiography: prevalence and insights into mechanistic differences using computational fluid dynamics, Open Heart, Vol: 6, ISSN: 2053-3624
Objectives The aims of this study were to evaluate the inconsistency of aortic stenosis (AS) severity between CT aortic valve area (CT-AVA) and echocardiographic Doppler parameters, and to investigate potential underlying mechanisms using computational fluid dynamics (CFD).Methods A total of 450 consecutive eligible patients undergoing transcatheter AV implantation assessment underwent CT cardiac angiography (CTCA) following echocardiography. CT-AVA derived by direct planimetry and echocardiographic parameters were used to assess severity. CFD simulation was performed in 46 CTCA cases to evaluate velocity profiles.Results A CT-AVA>1 cm2 was present in 23% of patients with echocardiographic peak velocity≥4 m/s (r=−0.33) and in 15% patients with mean Doppler gradient≥40 mm Hg (r=−0.39). Patients with inconsistent severity grading between CT and echocardiography had higher stroke volume index (43 vs 38 mL/m2, p<0.003) and left ventricular outflow tract (LVOT) flow rate (235 vs 192 cm3/s, p<0.001). CFD simulation revealed high flow, either in isolation (p=0.01), or when associated with a skewed velocity profile (p=0.007), as the main cause for inconsistency between CT and echocardiography.Conclusion Severe AS by Doppler criteria may be associated with a CT-AVA>1 cm2 in up to a quarter of patients. CFD demonstrates that haemodynamic severity may be exaggerated on Doppler analysis due to high LVOT flow rates, with or without skewed velocity profiles, across the valve orifice. These factors should be considered before making a firm diagnosis of severe AS and evaluation with CT can be helpful.
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