Imperial College London

DrMilesDalby

Faculty of MedicineNational Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

miles.dalby

 
 
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Location

 

Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
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143 results found

UK TAVI Trial Investigators, Toff WD, Hildick-Smith D, Kovac J, Mullen MJ, Wendler O, Mansouri A, Rombach I, Abrams KR, Conroy SP, Flather MD, Gray AM, MacCarthy P, Monaghan MJ, Prendergast B, Ray S, Young CP, Crossman DC, Cleland JGF, de Belder MA, Ludman PF, Jones S, Densem CG, Tsui S, Kuduvalli M, Mills JD, Banning AP, Sayeed R, Hasan R, Fraser DGW, Trivedi U, Davies SW, Duncan A, Curzen N, Ohri SK, Malkin CJ, Kaul P, Muir DF, Owens WA, Uren NG, Pessotto R, Kennon S, Awad WI, Khogali SS, Matuszewski M, Edwards RJ, Ramesh BC, Dalby M, Raja SG, Mariscalco G, Lloyd C, Cox ID, Redwood SR, Gunning MG, Ridley PDet al., 2022, Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial., JAMA, Vol: 327, Pages: 1875-1887

Importance: Transcatheter aortic valve implantation (TAVI) is a less invasive alternative to surgical aortic valve replacement and is the treatment of choice for patients at high operative risk. The role of TAVI in patients at lower risk is unclear. Objective: To determine whether TAVI is noninferior to surgery in patients at moderately increased operative risk. Design, Setting, and Participants: In this randomized clinical trial conducted at 34 UK centers, 913 patients aged 70 years or older with severe, symptomatic aortic stenosis and moderately increased operative risk due to age or comorbidity were enrolled between April 2014 and April 2018 and followed up through April 2019. Interventions: TAVI using any valve with a CE mark (indicating conformity of the valve with all legal and safety requirements for sale throughout the European Economic Area) and any access route (n = 458) or surgical aortic valve replacement (surgery; n = 455). Main Outcomes and Measures: The primary outcome was all-cause mortality at 1 year. The primary hypothesis was that TAVI was noninferior to surgery, with a noninferiority margin of 5% for the upper limit of the 1-sided 97.5% CI for the absolute between-group difference in mortality. There were 36 secondary outcomes (30 reported herein), including duration of hospital stay, major bleeding events, vascular complications, conduction disturbance requiring pacemaker implantation, and aortic regurgitation. Results: Among 913 patients randomized (median age, 81 years [IQR, 78 to 84 years]; 424 [46%] were female; median Society of Thoracic Surgeons mortality risk score, 2.6% [IQR, 2.0% to 3.4%]), 912 (99.9%) completed follow-up and were included in the noninferiority analysis. At 1 year, there were 21 deaths (4.6%) in the TAVI group and 30 deaths (6.6%) in the surgery group, with an adjusted absolute risk difference of -2.0% (1-sided 97.5% CI, -∞ to 1.2%; P < .001 for noninferiority). Of 30 p

Journal article

Kite TA, Banning AS, Ladwiniec A, Gale CP, Greenwood JP, Dalby M, Hobson R, Barber S, Parker E, Berry C, Flather MD, Curzen N, Banning AP, McCann GP, Gershlick AHet al., 2022, Very early invasive angiography versus standard of care in higher-risk non-ST elevation myocardial infarction: study protocol for the prospective multicentre randomised controlled RAPID N-STEMI trial, BMJ OPEN, Vol: 12, ISSN: 2044-6055

Journal article

Demir OM, Little CD, Jabbour R, Rahman H, Sayers M, Ahmed A, Connolly MJ, Kanyal R, MacCarthy P, Wilson SJ, Dalby M, Jain A, Malik I, Rakhit R, Perera Det al., 2021, Impact of COVID-19 pandemic on the management of nonculprit lesions in patients presenting with ST-elevation myocardial infarction: Outcomes from the pan-London heart attack centers, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 99, Pages: 391-396, ISSN: 1522-1946

Journal article

Kalogeras K, Zuhair M, Kabir T, Jabbour R, Dalby M, Ghada M, Shai S, Katsianos E, Iqbal M, Naganuma T, Davies S, Shannon J, Duncan A, Vavuranakis M, Panoulas Vet al., 2021, Real-world comparison of the last generation balloon-expandable and self-expanding valves in patients undergoing TAVI, ESC, Publisher: OXFORD UNIV PRESS, Pages: 2191-2191, ISSN: 0195-668X

Conference paper

Panoulas V, Rathod KS, Jain AK, Firoozi S, Nevett J, Kalra SS, Malik IS, Mathur A, Redwood S, MacCarthy PA, Wragg A, Jones DA, Dalby MCet al., 2021, Impact of Early (<= 24 h) Versus Delayed (> 24 h) Intervention in Patients With Non-ST Segment Elevation Myocardial Infarction: An Observational Study of 20,882 Patients From the London Heart Attack Group, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 22, Pages: 3-7, ISSN: 1553-8389

Journal article

Rathod KS, Jones DA, Jain AK, Lim P, MacCarthy PA, Rakhit R, Lockie T, Kalra S, Dalby MC, Malik IS, Whitbread M, Firoozi S, Bogle R, Redwood S, Cooper J, Gupta A, Lansky A, Wragg A, Mathur A, Ahluwalia Aet al., 2021, The influence of biological age and sex on long-term outcome after percutaneous coronary intervention for ST-elevation myocardial infarction, AMERICAN JOURNAL OF CARDIOVASCULAR DISEASE, Vol: 11, Pages: 659-+, ISSN: 2160-200X

Journal article

Kalogeras K, Ruparelia N, Kabir T, Jabbour R, Kalantzis C, Bei E, Katsianos E, Naganuma T, Nakamura S, Sent S, Malik IS, Mikhail G, Dalby M, Vavuranakis M, Panoulas Vet al., 2020, Real-world comparison of the last generation main balloon-expandable and self-expanding valves in patients undergoing TAVI. Does the type matter?, European-Society-of-Cardiology (ESC) Congress, Publisher: OXFORD UNIV PRESS, Pages: 1953-1953, ISSN: 0195-668X

Conference paper

Rajakulasingam R, Nielles-Vallespin S, Ferreira PF, Scott AD, Khalique Z, Rogers P, Barnes G, Tindale A, Prendergast C, Cantor E, Wage R, Dalby M, Firmin DN, Pennell DJ, De Silva Ret al., 2020, Diffusion tensor cardiovascular magnetic resonance detects altered myocardial microstructure in patients with acute st-elevation myocardial infarction, European-Society-of-Cardiology (ESC) Congress, Publisher: OXFORD UNIV PRESS, Pages: 208-208, ISSN: 0195-668X

Conference paper

Kalogeras K, Ruparelia N, Kabir T, Jabbour R, Naganuma T, Vavuranakis M, Nakamura S, Wang B, Sen S, Hadjiloizou N, Malik IS, Mikhail G, Dalby M, Panoulas Vet al., 2020, Comparison of the self-expanding Evolut-PRO transcatheter aortic valve to its predecessor Evolut-R in the real world multicenter ATLAS registry, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 310, Pages: 120-125, ISSN: 0167-5273

Journal article

Rathod KS, Beirne A-M, Bogle R, Firoozi S, Lim P, Hill J, Dalby MC, Jain AK, Malik IS, Mathur A, Kalra SS, DeSilva R, Redwood S, MacCarthy PA, Wragg A, Smith EJ, Jones DAet al., 2020, Prior Coronary Artery Bypass Graft Surgery and Outcome After Percutaneous Coronary Intervention: An Observational Study From the Pan-London Percutaneous Coronary Intervention Registry, JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol: 9

Journal article

Vela MM, Simon A, Gil FR, Rosenberg A, Dalby M, Kabir T, Saez DG, Panoulas Vet al., 2020, Clinical Indications of IMPELLA Short-Term Mechanical Circulatory Support in a Tertiary Centre, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 21, Pages: 629-637, ISSN: 1553-8389

Journal article

Rathod KS, Jain AK, Firoozi S, Lim P, Boyle R, Nevett J, Dalby MC, Kalra S, Malik IS, Sirker A, Mathur A, Redwood S, MacCarthy PA, Wragg A, Jones DAet al., 2020, Outcome of inter-hospital transfer versus direct admission for primary percutaneous coronary intervention: An observational study of 25,315 patients with ST-elevation myocardial infarction from the London Heart Attack Group, EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE, Vol: 9, Pages: 948-957, ISSN: 2048-8726

Journal article

Rathod KS, Koganti S, Jain AK, Rakhit R, Dalby MC, Lockie T, Kalra S, Malik IS, Knight CJ, Whitbread M, Mathur A, Firoozi S, Bogle R, Redwood S, MacCarthy PA, Sirker A, O'Mahony C, Wragg A, Jones DAet al., 2020, Complete Versus Culprit only Revascularisation in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction: Incidence and Outcomes from the London Heart Attack Group, CARDIOVASCULAR REVASCULARIZATION MEDICINE, Vol: 21, Pages: 350-358, ISSN: 1553-8389

Journal article

Little CD, Kotecha T, Candilio L, Jabbour RJ, Collins GB, Ahmed A, Connolly M, Kanyal R, Demir OM, Lawson LO, Wang B, Firoozi S, Spratt JC, Perera D, MacCarthy P, Dalby M, Jain A, Wilson SJ, Malik I, Rakhit Ret al., 2020, COVID-19 pandemic and STEMI: pathway activation and outcomes from the pan-London heart attack group, OPEN HEART, Vol: 7, ISSN: 2053-3624

Journal article

Gershlick AH, Banning AS, Parker E, Wang D, Budgeon CA, Kelly DJ, Kane PO, Dalby M, Hetherington SL, McCann GP, Greenwood JP, Curzen Net al., 2019, Long-Term Follow-Up of Complete Versus Lesion-Only Revascularization in STEMI and Multivessel Disease The CvLPRIT Trial, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 74, Pages: 3083-3094, ISSN: 0735-1097

Journal article

Dalby M, 2019, Christmas 2019 and New Year Greetings, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 3875-3878, ISSN: 0195-668X

Journal article

Dalby M, 2019, London Shock 19-Extending Options for Patients with Cardiogenic Shock, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 3875-3878, ISSN: 0195-668X

Journal article

Dowling C, Firoozi S, Panoulas V, Dalby M, Kashyap MN, Kabir T, Kalogeras K, Buch MH, Levy R, Chowdhary S, Saraf S, Roberts D, More R, Wiper A, Abdelaziz HK, Neylon A, Mylotte D, Pisaniello AD, Fraser DGW, Anderson R, Cunnington MS, Malkin CJ, Blackman DJ, Brennan PF, Owens CG, Manoharan G, Spence MS, Brecker SJet al., 2019, Initial experience of a self-expanding transcatheter aortic valve with an outer pericardial wrap: The United Kingdom and Ireland Implanters' registry, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 95, Pages: 1340-1346, ISSN: 1522-1946

Journal article

Panoulas VF, Ilsley CJ, Kalogeras K, Khan H, Vela MM, Dalby M, Kabir T, Smith RD, Mason M, Grocott-Mason R, Cummings I, Luscher TF, Raja SGet al., 2019, Coronary artery bypass confers intermediate-term survival benefit over percutaneous coronary intervention with new-generation stents in real-world patients with multivessel coronary artery disease, including left main disease: a retrospective analysis of 6383 patients, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, Vol: 56, Pages: 911-918, ISSN: 1010-7940

Journal article

Kalogeras K, Jabbour RJ, Ruparelia N, Watson S, Kabir T, Naganuma T, Vavuranakis M, Nakamura S, Malik IS, Mikhail G, Dalby M, Panoulas Vet al., 2019, Comparison of warfarin versus DOACs in patients with concomitant indication for oral anticoagulation undergoing TAVI; results from the ATLAS registry, JOURNAL OF THROMBOSIS AND THROMBOLYSIS, Vol: 50, Pages: 82-89, ISSN: 0929-5305

Journal article

Beirne A, Rathod K, Jain A, Mathur A, Wragg A, Smith EJ, Jones DA, Kalra S, Malik I, Redwood S, MacCarthy P, Bogle R, Firoozi S, Dalby Met al., 2019, The association between prior coronary artery bypass graft surgery and outcome after percutaneous coronary intervention (PCI): an observational study of 123,780 patients, Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Publisher: OXFORD UNIV PRESS, Pages: 4112-4112, ISSN: 0195-668X

Conference paper

Mittal TK, Reichmuth L, Bhattacharyya S, Jain M, Baltabaeva A, Haley SR, Mirsadraee S, Panoulas V, Kabir T, Nicol ED, Dalby M, Long Qet al., 2019, Inconsistency in aortic stenosis severity between CT and echocardiography: prevalence and insights into mechanistic differences using computational fluid dynamics, Open Heart, Vol: 6, ISSN: 2053-3624

Objectives The aims of this study were to evaluate the inconsistency of aortic stenosis (AS) severity between CT aortic valve area (CT-AVA) and echocardiographic Doppler parameters, and to investigate potential underlying mechanisms using computational fluid dynamics (CFD).Methods A total of 450 consecutive eligible patients undergoing transcatheter AV implantation assessment underwent CT cardiac angiography (CTCA) following echocardiography. CT-AVA derived by direct planimetry and echocardiographic parameters were used to assess severity. CFD simulation was performed in 46 CTCA cases to evaluate velocity profiles.Results A CT-AVA>1 cm2 was present in 23% of patients with echocardiographic peak velocity≥4 m/s (r=−0.33) and in 15% patients with mean Doppler gradient≥40 mm Hg (r=−0.39). Patients with inconsistent severity grading between CT and echocardiography had higher stroke volume index (43 vs 38 mL/m2, p<0.003) and left ventricular outflow tract (LVOT) flow rate (235 vs 192 cm3/s, p<0.001). CFD simulation revealed high flow, either in isolation (p=0.01), or when associated with a skewed velocity profile (p=0.007), as the main cause for inconsistency between CT and echocardiography.Conclusion Severe AS by Doppler criteria may be associated with a CT-AVA>1 cm2 in up to a quarter of patients. CFD demonstrates that haemodynamic severity may be exaggerated on Doppler analysis due to high LVOT flow rates, with or without skewed velocity profiles, across the valve orifice. These factors should be considered before making a firm diagnosis of severe AS and evaluation with CT can be helpful.

Journal article

Jones DA, Rathod KS, Koganti S, Lim P, Firoozi S, Bogle R, Jain AK, MacCarthy PA, Dalby MC, Malik IS, Mathur A, DeSilva R, Rakhit R, Kalra SS, Redwood S, Ludman P, Wragg Aet al., 2019, The association between the public reporting of individual operator outcomes with patient profiles, procedural management, and mortality after percutaneous coronary intervention: an observational study from the Pan-London PCI (BCIS) Registry using an interrupted time series analysis, EUROPEAN HEART JOURNAL, Vol: 40, Pages: 2620-2629, ISSN: 0195-668X

Journal article

Dowling C, Firoozi S, Doyle N, Blackman DJ, Malkin CJ, Cunnington MS, Saraf S, Buch MH, Levy R, Chowdhary S, Spence MS, Manoharan G, Owens CG, Brennan PF, Roberts D, More R, Wiper A, Abdelaziz HK, Mylotte D, Neylon A, Martin N, Mercanti F, Dorman S, Panoulas V, Dalby M, Kashyap MN, Kabir T, Kovac J, Kontoprias K, Malik IS, Ghada MW, Sen S, Ruparelia N, Demir OM, Frame A, Uren NG, Anderson R, Rajathurai T, Tapp L, Deegan L, Grech E, Hall I, Neville M, Rampat R, Hildick-Smith D, Mullen M, Kennon S, Chandrala P, Doshi S, Brecker SJet al., 2019, Initial experience of a large, self-expanding, and fully recapturable transcatheter aortic valve: The UK & Ireland Implanters' registry, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 93, Pages: 751-757, ISSN: 1522-1946

Journal article

Kalogeras K, Kabir T, Mittal T, Mirsadraee S, Skondras E, Haley SR, Zuhair M, Vavuranakis M, Tousoulis D, Dalby M, Panoulas Vet al., 2019, Real-world comparison of the new 34 mm self-expandable transcatheter aortic prosthesis Evolut R to its 31 mm core valve predecessor, CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Vol: 93, Pages: 685-691, ISSN: 1522-1946

Journal article

Rathod KS, Koganti S, Jain AK, Astroulakis Z, Lim P, Rakhit R, Kalra SS, Dalby MC, O'Mahony C, Malik IS, Knight CJ, Mathur A, Redwood S, Sirker A, MacCarthy PA, Smith EJ, Wragg A, Jones DAet al., 2018, Complete Versus Culprit-Only Lesion Intervention in Patients With Acute Coronary Syndromes, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 72, Pages: 1989-1999, ISSN: 0735-1097

Journal article

Patterson T, Perkins A, Perkins GD, Clayton T, Evans R, Nguyen H, Wilson K, Whitbread M, Hughes J, Fothergill RT, Nevett J, Mosweu I, McCrone P, Dalby M, Rakhit R, MacCarthy P, Perera D, Nolan JP, Redwood SRet al., 2018, Rationale and design of: A Randomized tRial of Expedited transfer to a cardiac arrest center for non-ST elevation out-of-hospital cardiac arrest: The ARREST randomized controlled trial, AMERICAN HEART JOURNAL, Vol: 204, Pages: 92-101, ISSN: 0002-8703

Journal article

Broyd CJ, Panoulas V, Mattar W, Akhtar M, Shekarchi-Khanghahi E, Ioannou A, Raja SG, Mason M, Rahman-Haley S, Skondras E, Dalby M, Luscher TF, Kabir Tet al., 2018, Effect of Aortic Valve Calcium Quantity on Outcome After Balloon Aortic Valvuloplasty for Severe Aortic Stenosis, AMERICAN JOURNAL OF CARDIOLOGY, Vol: 122, Pages: 1036-1041, ISSN: 0002-9149

Journal article

Rogers P, Banya W, Kabir T, Panoulas V, Probert H, Prendergast C, Taylor R, Dalby Met al., 2018, Does cardiac rehabilitation improve functional, independence, frailty and emotional outcomes following trans catheter aortic valve replacement?, European-Society-of-Cardiology Congress, Publisher: OXFORD UNIV PRESS, Pages: 1121-1121, ISSN: 0195-668X

Conference paper

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