Imperial College London
Alternate

DrMonicaPirani

Faculty of Medicine, School of Public Health

Lecturer in Biostatistics
 
 
 
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monica.pirani

 
 
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Location

 

706School of Public HealthWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Morandi:2016:alcalc/agv058,
author = {Morandi, G and Periche, Tomas E and Pirani, M},
doi = {alcalc/agv058},
journal = {Alcohol and Alcoholism},
pages = {63--70},
title = {Mortality risk in alcoholic patients in northern Italy: comorbidity and treatment retention effects in a 30-year follow-up study},
url = {http://dx.doi.org/10.1093/alcalc/agv058},
volume = {51},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Aims To analyse the general and cause-specific mortality over the course of 30 years among subjects treated for alcohol use disorders (AUD) in Northern Italy.Methods Cohort of 2499 subjects followed-up for mortality until 31 December 2012. Standardized mortality ratios (SMRs) and 95% confidence intervals (CI) were computed to compare the mortality in the cohort with the general population. Cox regression was used to study the effect of psychiatric disorders, burden of physical comorbidity and retention in treatment on mortality, controlling for socio-demographic factors.Results During the follow-up, 435 deaths occurred. Compared with the general population, alcoholics experienced a 5-fold increased mortality (SMR: 5.53; 95% CI: 5.03, 6.07). Significant excess mortality was observed for a range of specific causes: infections, cancers, cardiovascular, respiratory and digestive system diseases as well as violent causes. In multivariate analysis, the hazard of dying was lower for female gender (hazard ratio [HR]: 0.62; 95% CI: 0.46, 0.84) and for increasing length of retention in treatment (HR for third tertile vs first tertile: 0.43; 95% CI: 0.32, 0.57). Burden of physical comorbidity was associated with increased hazard of dying (HR for 3+ comorbidities vs no comorbidities: 4.40; 95% CI: 2.91, 6.66). Psychiatric comorbidity was not associated with mortality.Conclusions Despite the harmful effect of AUD, retention in treatment represented a protective factor against death, suggesting that strategies supporting primary medical- and social-care may effectively reduce premature mortality.
AU  - Morandi,G
AU  - Periche,Tomas E
AU  - Pirani,M
DO  - alcalc/agv058
EP  - 70
PY  - 2016///
SN  - 1464-3502
SP  - 63
TI  - Mortality risk in alcoholic patients in northern Italy: comorbidity and treatment retention effects in a 30-year follow-up study
T2  - Alcohol and Alcoholism
UR  - http://dx.doi.org/10.1093/alcalc/agv058
VL  - 51
ER  -
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