Imperial College London
Alternate

DrNathanBartlett

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Lecturer
 
 
 
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Contact

 

n.bartlett

 
 
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Location

 

Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Glanville:2013:10.1038/mi.2013.3,
author = {Glanville, N and Message, SD and Walton, RP and Pearson, RM and Parker, HL and Laza-Stanca, V and Mallia, P and Kebadze, T and Contoli, M and Kon, OM and Papi, A and Stanciu, LA and Johnston, SL and Bartlett, NW},
doi = {10.1038/mi.2013.3},
journal = {Mucosal Immunology},
pages = {1091--1100},
title = {γδT cells suppress inflammation and disease during rhinovirus-induced asthma exacerbations},
url = {http://dx.doi.org/10.1038/mi.2013.3},
volume = {6},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Most asthma exacerbations are triggered by virus infections, the majority being caused by human rhinoviruses (RV). In mouse models, γδT cells have been previously demonstrated to influence allergen-driven airways hyper-reactivity (AHR) and can have antiviral activity, implicating them as prime candidates in the pathogenesis of asthma exacerbations. To explore this, we have used human and mouse models of experimental RV-induced asthma exacerbations to examine γδT-cell responses and determine their role in the immune response and associated airways disease. In humans, airway γδT-cell numbers were increased in asthmatic vs. healthy control subjects during experimental infection. Airway and blood γδT-cell numbers were associated with increased airways obstruction and AHR. Airway γδT-cell number was also positively correlated with bronchoalveolar lavage (BAL) virus load and BAL eosinophils and lymphocytes during RV infection. Consistent with our observations of RV-induced asthma exacerbations in humans, infection of mice with allergic airways inflammation increased lung γδT-cell number and activation. Inhibiting γδT-cell responses using anti-γδTCR (anti-γδT-cell receptor) antibody treatment in the mouse asthma exacerbation model increased AHR and airway T helper type 2 cell recruitment and eosinophilia, providing evidence that γδT cells are negative regulators of airways inflammation and disease in RV-induced asthma exacerbations.
AU  - Glanville,N
AU  - Message,SD
AU  - Walton,RP
AU  - Pearson,RM
AU  - Parker,HL
AU  - Laza-Stanca,V
AU  - Mallia,P
AU  - Kebadze,T
AU  - Contoli,M
AU  - Kon,OM
AU  - Papi,A
AU  - Stanciu,LA
AU  - Johnston,SL
AU  - Bartlett,NW
DO  - 10.1038/mi.2013.3
EP  - 1100
PY  - 2013///
SN  - 1933-0219
SP  - 1091
TI  - γδT cells suppress inflammation and disease during rhinovirus-induced asthma exacerbations
T2  - Mucosal Immunology
UR  - http://dx.doi.org/10.1038/mi.2013.3
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000325916800004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/mi20133
UR  - http://hdl.handle.net/10044/1/89215
VL  - 6
ER  -
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