Imperial College London
Alternate

DrNathanBartlett

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Lecturer
 
 
 
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n.bartlett

 
 
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Location

 

Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jayaraman:2014:10.1038/mi.2014.2,
author = {Jayaraman, A and Jackson, DJ and Message, SD and Pearson, RM and Aniscenko, J and Caramori, G and Mallia, P and Papi, A and Shamji, B and Edwards, M and Westwick, J and Hansel, T and Stanciu, LA and Johnston, SL and Bartlett, NW},
doi = {10.1038/mi.2014.2},
journal = {MUCOSAL IMMUNOLOGY},
pages = {1151--1164},
title = {IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection},
url = {http://dx.doi.org/10.1038/mi.2014.2},
volume = {7},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rhinoviruses are among the most common viruses to infect man, causing a range of serious respiratory diseases including exacerbations of asthma and COPD. Type I IFN and IL-15 are thought to be required for antiviral immunity; however, their function during rhinovirus infection in vivo is undefined. In RV-infected human volunteers, IL-15 protein expression in fluid from the nasal mucosa and in bronchial biopsies was increased. In mice, RV induced type I IFN-dependent expressions of IL-15 and IL-15Rα, which in turn were required for NK- and CD8+ T-cell responses. Treatment with IL-15–IL-15Rα complexes (IL-15c) boosted RV-induced expression of IL-15, IL-15Rα, IFN-γ, CXCL9, and CXCL10 followed by recruitment of activated, IFN-γ-expressing NK, CD8+, and CD4+ T cells. Treating infected IFNAR1−/− mice with IL-15c similarly increased IL-15, IL-15Rα, IFN-γ, and CXCL9 (but not CXCL10) expression also followed by NK-, CD8+-, and CD4+-T-cell recruitment and activation. We have demonstrated that type I IFN-induced IFN-γ and cellular immunity to RV was mediated by IL-15 and IL-15Rα. Importantly, we also show that IL-15 could be induced via a type I IFN-independent mechanism by IL-15 complex treatment, which in turn was sufficient to drive IFN-γ expression and lymphocyte responses.
AU  - Jayaraman,A
AU  - Jackson,DJ
AU  - Message,SD
AU  - Pearson,RM
AU  - Aniscenko,J
AU  - Caramori,G
AU  - Mallia,P
AU  - Papi,A
AU  - Shamji,B
AU  - Edwards,M
AU  - Westwick,J
AU  - Hansel,T
AU  - Stanciu,LA
AU  - Johnston,SL
AU  - Bartlett,NW
DO  - 10.1038/mi.2014.2
EP  - 1164
PY  - 2014///
SN  - 1933-0219
SP  - 1151
TI  - IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection
T2  - MUCOSAL IMMUNOLOGY
UR  - http://dx.doi.org/10.1038/mi.2014.2
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341215600012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/mi20142
UR  - http://hdl.handle.net/10044/1/89293
VL  - 7
ER  -
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