Imperial College London
Alternate

DrNathanBartlett

Faculty of Medicine, National Heart & Lung Institute

Honorary Senior Lecturer
 
 
 
//

Contact

 

n.bartlett

 
 
//

Location

 

Wright Fleming WingSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Girkin:2015:10.4049/jimmunol.1401362,
author = {Girkin, J and Hatchwell, L and Foster, P and Johnston, SL and Bartlett, N and Collison, A and Mattes, J},
doi = {10.4049/jimmunol.1401362},
journal = {Journal of Immunology},
pages = {4924--4930},
title = {CCL7 and IRF-7 Mediate Hallmark Inflammatory and IFN Responses following Rhinovirus 1B Infection},
url = {http://dx.doi.org/10.4049/jimmunol.1401362},
volume = {194},
year = {2015}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rhinovirus (RV) infections are common and have the potential to exacerbate asthma. We have determined the lung transcriptome in RV strain 1B–infected naive BALB/c mice (nonallergic) and identified CCL7 and IFN regulatory factor (IRF)-7 among the most upregulated mRNA transcripts in the lung. To investigate their roles we employed anti-CCL7 Abs and an IRF-7–targeting small interfering RNA in vivo. Neutralizing CCL7 or inhibiting IRF-7 limited neutrophil and macrophage influx and IFN responses in nonallergic mice. Neutralizing CCL7 also reduced activation of NF-κB p65 and p50 subunits, as well as airway hyperreactivity (AHR) in nonallergic mice. However, neither NF-κB subunit activation nor AHR was abolished with infection of allergic mice after neutralizing CCL7, despite a reduction in the number of neutrophils, macrophages, and eosinophils. IRF-7 small interfering RNA primarily suppressed IFN-α and IFN-β levels during infection of allergic mice. Our data highlight a pivotal role of CCL7 and IRF-7 in RV-induced inflammation and IFN responses and link NF-κB signaling to the development of AHR.
AU  - Girkin,J
AU  - Hatchwell,L
AU  - Foster,P
AU  - Johnston,SL
AU  - Bartlett,N
AU  - Collison,A
AU  - Mattes,J
DO  - 10.4049/jimmunol.1401362
EP  - 4930
PY  - 2015///
SN  - 1550-6606
SP  - 4924
TI  - CCL7 and IRF-7 Mediate Hallmark Inflammatory and IFN Responses following Rhinovirus 1B Infection
T2  - Journal of Immunology
UR  - http://dx.doi.org/10.4049/jimmunol.1401362
VL  - 194
ER  -
Download