Imperial College London
Alternate

Dr Nick Brooks

Faculty of Natural Sciences, Department of Chemistry

Reader in Membrane Biophysics
 
 
 
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Contact

 

+44 (0)20 7594 2677n.brooks Website

 
 
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Location

 

207JMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{McCarthy:2017:10.1016/j.cplett.2016.12.041,
author = {McCarthy, NL and Brooks, NJ and Tyler, AII and ElGamacy, M and Welche, P and Payne, MC and Chau, PL},
doi = {10.1016/j.cplett.2016.12.041},
journal = {Chemical Physics Letters},
pages = {21--27},
title = {A combined X-ray scattering and simulation study of halothane in membranes at raised pressures},
url = {http://dx.doi.org/10.1016/j.cplett.2016.12.041},
volume = {671},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Using  a  combination  of  high  pressure  wide  angle  X-ray  scattering  exper-iments  and  molecular  dynamics  simulations,  we  probe  the  e ect  of  thearchetypal  general  anaesthetic  halothane  on  the  lipid  hydrocarbon  chainpacking and ordering in model bilayers and the variation in these parame-ters with pressure.  Incorporation of halothane into the membrane causes anexpansion of the lipid hydrocarbon chain packing at all pressures but thee ect of halothane incorporation on the hydrocarbon chain order parameteris signi cantly reduced at elevated pressure.
AU  - McCarthy,NL
AU  - Brooks,NJ
AU  - Tyler,AII
AU  - ElGamacy,M
AU  - Welche,P
AU  - Payne,MC
AU  - Chau,PL
DO  - 10.1016/j.cplett.2016.12.041
EP  - 27
PY  - 2017///
SN  - 0009-2614
SP  - 21
TI  - A combined X-ray scattering and simulation study of halothane in membranes at raised pressures
T2  - Chemical Physics Letters
UR  - http://dx.doi.org/10.1016/j.cplett.2016.12.041
UR  - http://www.sciencedirect.com/science/article/pii/S000926141630999X
UR  - http://hdl.handle.net/10044/1/43270
VL  - 671
ER  -
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