Naomi Chayen is Head of the Crystallization Group in Computational and Systems Medicine
Structural biology and structural genomics/proteomics.
- Crystallization of proteins and other biological molecules of medical interest for the purpose of 3-D structure determination for rational drug design
- Crystallization of proteins related to cancer therapy
- Analytical studies in order to gain an a fundamental understanding of the crystallization process and apply this knowledge to solve crystallization problems
- Design of new, non-standard methodology for production of high-quality crystals for X-ray crystallography
- Design and application of smart and nano materials for crystallization
- Automation and miniaturization to nano-scale crystallization in high throughput mode
- Women of Outstanding Achievement for Innovation & Entrepreneurship Commendation (2012)
- Innovator of the Year (2011)
- Investigator of the Year (2011)
- Nine patents and several commercial products.
- "Chayen Reddy MIP"
- "Naomi's Nucleant"
- 7 commercial kits for crystallization sold by SME's
Press Report Highlights
et al., 2020, The structure-function relationship of oncogenic LMTK3, Science Advances, Vol:6, ISSN:2375-2548
et al., 2019, Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions, Nature Communications, Vol:10, ISSN:2041-1723
et al., 2019, Hydrophobic Interface-assisted protein crystallization: theory and experiment, ACS Applied Materials & Interfaces, Vol:11, ISSN:1944-8244, Pages:12931-12940
et al., 2018, Chlamydia protein Pgp3 studied at high resolution in a new crystal form, Iucrj, Vol:5, ISSN:2052-2525, Pages:439-448
Nanev CN, Saridakis E, Chayen N, 2017, Protein crystal nucleation in pores, Scientific Reports, Vol:7, ISSN:2045-2322
et al., 2014, Porous nucleating agents for protein crystallization, Nature Protocols, Vol:9, ISSN:1750-2799, Pages:1621-1633
et al., 2012, The OPCML Tumor Suppressor Functions as a Cell Surface Repressor–Adaptor, Negatively Regulating Receptor Tyrosine Kinases in Epithelial Ovarian Cancer, Cancer Discovery
Chayen NE, Saridakis E, 2008, Protein crystallization: "From purified protein to diffraction quality crystals", Nature Methods, Pages:147-153
Chayen, N.E., 2004, Turning protein crystallization from an art into a science, Current Opinion in Structural Biology, Vol:14, ISSN:0959-440X, Pages:577-583