Imperial College London


Faculty of MedicineDepartment of Immunology and Inflammation

Clinical Reader in Immunohaematology







Miss Mandy Sale +44 (0)20 3313 4017




4S10CCommonwealth BuildingHammersmith Campus





Our research focuses on understanding the molecular basis of autoimmune conditions in haematology, particularly immune thrombocytopenia (ITP), a condition leading to premature destruction of platelets.

We combine genetic and genomic analysis of individuals with extreme phenotypes, CRISPR-based in vitro functional validation, and parallel ‘omic' approaches to define novel pathways regulating autoimmunity (eg Afzaku B et al Nat Immunol 2017 18:813-823).



Vergis N, Phillips R, Cornelius V, et al., 2021, Multi-arm Trial of Inflammatory Signal Inhibitors (MATIS) for hospitalised patients with mild or moderate COVID-19 pneumonia: a structured summary of a study protocol for a randomised controlled trial, Trials, Vol:22, ISSN:1745-6215

Rosas IO, Brau N, Waters M, et al., 2021, Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia, New England Journal of Medicine, Vol:384, ISSN:0028-4793, Pages:1503-1516

Cooper N, Morrison MA, Vladescu C, et al., 2020, Identification of occult cerebral microbleeds in adults with immune thrombocytopenia, Blood, Vol:136, ISSN:0006-4971, Pages:2875-2880

Tarantino MD, Despotovic J, Roy J, et al., 2020, Romiplostim treatment for children with immune thrombocytopenia: Results of an integrated database of five clinical trials, Pediatric Blood & Cancer, Vol:67, ISSN:1545-5009

Thaventhiran JED, Lango Allen H, Burren OS, et al., 2020, Whole-genome sequencing of a sporadic primary immunodeficiency cohort (vol 583, pg 90, 2020), Nature, Vol:584, ISSN:0028-0836, Pages:E2-E2

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