Imperial College London


Faculty of MedicineDepartment of Immunology and Inflammation

Professor of Immune Haematology







Miss Mandy Sale +44 (0)20 3313 4017




4S10CCommonwealth BuildingHammersmith Campus





Our research focuses on understanding the molecular basis of autoimmune conditions in haematology, particularly immune thrombocytopenia (ITP), a condition leading to premature destruction of platelets.

We combine genetic and genomic analysis of individuals with extreme phenotypes, CRISPR-based in vitro functional validation, and parallel ‘omic' approaches to define novel pathways regulating autoimmunity (eg Afzaku B et al Nat Immunol 2017 18:813-823).



Malik A, Sayed AA, Han P, et al., 2023, The role of CD8+ T cell clones in immune thrombocytopenia, Blood, Vol:141, ISSN:0006-4971, Pages:2417-2429

Robbins AJ, Che Bakri NA, Toke-Bjolgerud E, et al., 2023, The effect of TRV027 on coagulation in COVID 19: A pilot randomized, placebo-controlled controlled trial, British Journal of Clinical Pharmacology, Vol:89, ISSN:0306-5251, Pages:1495-1501

Grainger J, Bussel J, Tarantino M, et al., 2023, A single-arm, long-term efficacy and safety study of subcutaneous romiplostim in children with immune thrombocytopenia., Blood Adv, Vol:7, Pages:396-405

Burnham KL, Maher AK, Jones EM, et al., 2022, Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19, Nature Communications, Vol:13, ISSN:2041-1723, Pages:1-17


McDonald V, Bradbury C, Talks K, et al., 2022, Retrospective, Observational, Multicenter Study Assessing the Thrombopoietin Receptor Agonist (TPO-RA) Romiplostim and Other Treatments for Patients with Newly Diagnosed or Persistent Primary Immune Thrombocytopenia (ITP) in Routine Clinical Practice in the United Kingdom (UK), 64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), AMER SOC HEMATOLOGY, Pages:2678-2680, ISSN:0006-4971

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