Imperial College London

DrNicholaCooper

Faculty of MedicineDepartment of Immunology and Inflammation

Clinical Reader in Immunohaematology
 
 
 
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Contact

 

n.cooper

 
 
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Assistant

 

Miss Mandy Sale +44 (0)20 3313 4017

 
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Location

 

4S10CCommonwealth BuildingHammersmith Campus

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Summary

 

Summary

Our research focuses on understanding the molecular basis of autoimmune conditions in haematology, particularly immune thrombocytopenia (ITP), a condition leading to premature destruction of platelets.
We combine genetic and genomic analysis of individuals with extreme phenotypes, CRISPR-based in vitro functional validation, and parallel ‘omic' approaches to define novel pathways regulating autoimmunity (eg Afzaku B et al Nat Immunol 2017 18:813-823).

Publications

Journals

Cooper N, Morrison MA, Vladescu C, et al., 2020, IDENTIFICATION OF OCCULT CEREBRAL MICROBLEEDS IN ADULTS WITH IMMUNE THROMBOCYTOPENIA., Blood

Thaventhiran JED, Lango Allen H, Burren OS, et al., 2020, Whole-genome sequencing of a sporadic primary immunodeficiency cohort, Nature, Vol:583, ISSN:0028-0836, Pages:90-95

Sharrack B, Saccardi R, Alexander T, et al., 2020, Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE)., Bone Marrow Transplantation, Vol:55, ISSN:0268-3369, Pages:283-306

Neunert C, Terrell DR, Arnold DM, et al., 2019, American Society of Hematology 2019 guidelines for immune thrombocytopenia, Blood Advances, Vol:3, ISSN:2473-9529, Pages:3829-3866

Downes K, Megy K, Duarte D, et al., 2019, Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders, Blood, Vol:134, ISSN:1528-0020, Pages:2082-2091

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