Imperial College London


Faculty of MedicineDepartment of Immunology and Inflammation

Professor of Immune Haematology







Miss Mandy Sale +44 (0)20 3313 4017




4S10CCommonwealth BuildingHammersmith Campus





Our research focuses on understanding the molecular basis of autoimmune conditions in haematology, particularly immune thrombocytopenia (ITP), a condition leading to premature destruction of platelets.

We combine genetic and genomic analysis of individuals with extreme phenotypes, CRISPR-based in vitro functional validation, and parallel ‘omic' approaches to define novel pathways regulating autoimmunity (eg Afzaku B et al Nat Immunol 2017 18:813-823).



Cooper N, Ghanima W, Vianelli N, et al., 2024, Sustained response off-treatment in eltrombopag-treated adult patients with ITP who are refractory or relapsed after first-line steroids: Primary, final, and ad-hoc analyses of the Phase II TAPER trial., Am J Hematol, Vol:99, Pages:57-67

Stefani S, Buti N, Hart ACJ, et al., 2024, Safety and efficacy of SARS-CoV-2 vaccination in patients with immune thrombocytopenia: A two-centre review., Br J Haematol, Vol:204, Pages:324-328

Malik A, Sayed AA, Han P, et al., 2023, The role of CD8+ T cell clones in immune thrombocytopenia, Blood, Vol:141, ISSN:0006-4971, Pages:2417-2429

Robbins AJ, Che Bakri NA, Toke-Bjolgerud E, et al., 2023, The effect of TRV027 on coagulation in COVID 19: A pilot randomized, placebo-controlled controlled trial, British Journal of Clinical Pharmacology, Vol:89, ISSN:0306-5251, Pages:1495-1501

Grainger J, Bussel J, Tarantino M, et al., 2023, A single-arm, long-term efficacy and safety study of subcutaneous romiplostim in children with immune thrombocytopenia., Blood Adv, Vol:7, Pages:396-405

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