Imperial College London


Faculty of MedicineDepartment of Immunology and Inflammation

Clinical Reader in Immunohaematology







Miss Mandy Sale +44 (0)20 3313 4017




4S10CCommonwealth BuildingHammersmith Campus





Our research focuses on understanding the molecular basis of autoimmune conditions in haematology, particularly immune thrombocytopenia (ITP), a condition leading to premature destruction of platelets.

We combine genetic and genomic analysis of individuals with extreme phenotypes, CRISPR-based in vitro functional validation, and parallel ‘omic' approaches to define novel pathways regulating autoimmunity (eg Afzaku B et al Nat Immunol 2017 18:813-823).



Robbins AJ, Che Bakri NA, Toke-Bjolgerud E, et al., 2022, The effect of TRV027 on coagulation in COVID 19: A pilot randomized, placebo-controlled controlled trial, British Journal of Clinical Pharmacology, ISSN:0306-5251

Cook L, O'dell G, Vourvou E, et al., 2022, Third primary SARS-CoV-2 mRNA vaccines enhance antibody responses in most patients with haematological malignancies, Nature Communications, ISSN:2041-1723

Joyce KE, Onabanjo E, Brownlow S, et al., 2022, Whole genome sequences discriminate hereditary hemorrhagic telangiectasia phenotypes by non-HHT deleterious DNA variants, Blood Advances, Vol:6, ISSN:2473-9529, Pages:3956-3969

Kuter DJ, Efraim M, Mayer J, et al., 2022, Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia, New England Journal of Medicine, Vol:386, ISSN:0028-4793, Pages:1421-1431

Grainger J, Bussel JB, Tarantino MD, et al., 2022, A Single-Arm, Long-Term Efficacy and Safety Study of Subcutaneous Romiplostim in Children with Immune Thrombocytopenia., Blood Adv

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