Imperial College London


Faculty of MedicineDepartment of Immunology and Inflammation

Clinical Senior Lecturer







Miss Mandy Sale +44 (0)20 3313 4017




4S10CCommonwealth BuildingHammersmith Campus





Our research focuses on understanding the molecular basis of autoimmune conditions in haematology, particularly immune thrombocytopenia (ITP), a condition leading to premature destruction of platelets.
We combine genetic and genomic analysis of individuals with extreme phenotypes, CRISPR-based in vitro functional validation, and parallel ‘omic' approaches to define novel pathways regulating autoimmunity (eg Afzaku B et al Nat Immunol 2017 18:813-823).



Vandrovcova J, Salzer U, Grimbacher B, et al., FAS mutations are an uncommon cause of immune thrombocytopenia in children and adults without additional features of immunodeficiency., Br J Haematol

Downes K, Megy K, Duarte D, et al., 2019, Diagnostic high-throughput sequencing of 2,396 patients with bleeding, thrombotic and platelet disorders, Blood, ISSN:1528-0020

Teraz-Orosz A, Nichola C, Crawley J, et al., 2019, Detection of anti-platelet antibodies in immune thrombocytopenia by flow cytometry, British Journal of Haematology, Vol:184, ISSN:1365-2141, Pages:844-847

Povoleri GAM, Nova-Lamperti E, Scotta C, et al., 2018, Human retinoic acid-regulated CD161(+) regulatory T cells support wound repair in intestinal mucosa, Nature Immunology, Vol:19, ISSN:1529-2908, Pages:1403-+

Lucchini E, Fanin R, Cooper N, et al., 2018, Management of immune thrombocytopenia in elderly patients, European Journal of Internal Medicine, Vol:58, ISSN:0953-6205, Pages:70-76

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