Imperial College London

DrNicholaCooper

Faculty of MedicineDepartment of Immunology and Inflammation

Clinical Reader in Immunohaematology
 
 
 
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Contact

 

n.cooper

 
 
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Assistant

 

Miss Mandy Sale +44 (0)20 3313 4017

 
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Location

 

4S10CCommonwealth BuildingHammersmith Campus

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Summary

 

Summary

Our research focuses on understanding the molecular basis of autoimmune conditions in haematology, particularly immune thrombocytopenia (ITP), a condition leading to premature destruction of platelets.

We combine genetic and genomic analysis of individuals with extreme phenotypes, CRISPR-based in vitro functional validation, and parallel ‘omic' approaches to define novel pathways regulating autoimmunity (eg Afzaku B et al Nat Immunol 2017 18:813-823).

Publications

Journals

Kuter DJ, Efraim M, Mayer J, et al., 2022, Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia, New England Journal of Medicine, Vol:386, ISSN:0028-4793, Pages:1421-1431

Grainger J, Bussel JB, Tarantino MD, et al., 2022, A Single-Arm, Long-Term Efficacy and Safety Study of Subcutaneous Romiplostim in Children with Immune Thrombocytopenia., Blood Adv

Joyce KE, Onabanjo E, Brownlow S, et al., 2022, Whole genome sequences discriminate hereditary hemorrhagic telangiectasia phenotypes by non-HHT deleterious DNA variants, Blood Advances, ISSN:2473-9529

Chauss D, Freiwald T, McGregor R, et al., 2021, Autocrine vitamin D signaling switches off pro-inflammatory programs of T(H)1 cells, Nature Immunology, Vol:23, ISSN:1529-2908, Pages:62-+

Bye AP, Hoepel W, Mitchell JL, et al., 2021, Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets, Blood, Vol:138, ISSN:0006-4971, Pages:1481-1489

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