Imperial College London
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ProfessorNicholaCooper

Faculty of Medicine, Department of Immunology and Inflammation

Professor of Immune Haematology
 
 
 
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Contact

 

n.cooper

 
 
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Assistant

 

Miss Mandy Sale +44 (0)20 3313 4017

 
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Location

 

4S10CCommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Povoleri:2018:10.7554/eLife.14814.001,
author = {Povoleri, GAM and Nova-Lamperti, E and Scotta, C and Fanelli, G and Chen, Y-C and Becker, PD and Boardman, D and Costantini, B and Romano, M and Pavlidis, P and McGregor, R and Pantazi, E and Chauss, D and Sun, H-W and Shih, H-Y and Cousins, DJ and Cooper, N and Powell, N and Kemper, C and Pirooznia, M and Laurence, A and Kordasti, S and Kazemian, M and Lombardi, G and Afzali, B},
doi = {10.7554/eLife.14814.001},
journal = {Nature Immunology},
pages = {1403--1414},
title = {Human retinoic acid-regulated CD161(+) regulatory T cells support wound repair in intestinal mucosa},
url = {http://dx.doi.org/10.7554/eLife.14814.001},
volume = {19},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T (Treg) cells as a distinct, highly suppressive population of Treg cells that mediate wound healing. These Treg cells were enriched in intestinal lamina propria, particularly in Crohn’s disease. CD161+ Treg cells had an all-trans retinoic acid (ATRA)-regulated gene signature, and CD161 expression on Treg cells was induced by ATRA, which directly regulated the CD161 gene. CD161 was co-stimulatory, and ligation with the T cell antigen receptor induced cytokines that accelerated the wound healing of intestinal epithelial cells. We identified a transcription-factor network, including BACH2, RORγt, FOSL2, AP-1 and RUNX1, that controlled expression of the wound-healing program, and found a CD161+ Treg cell signature in Crohn’s disease mucosa associated with reduced inflammation. These findings identify CD161+ Treg cells as a population involved in controlling the balance between inflammation and epithelial barrier healing in the gut.
AU  - Povoleri,GAM
AU  - Nova-Lamperti,E
AU  - Scotta,C
AU  - Fanelli,G
AU  - Chen,Y-C
AU  - Becker,PD
AU  - Boardman,D
AU  - Costantini,B
AU  - Romano,M
AU  - Pavlidis,P
AU  - McGregor,R
AU  - Pantazi,E
AU  - Chauss,D
AU  - Sun,H-W
AU  - Shih,H-Y
AU  - Cousins,DJ
AU  - Cooper,N
AU  - Powell,N
AU  - Kemper,C
AU  - Pirooznia,M
AU  - Laurence,A
AU  - Kordasti,S
AU  - Kazemian,M
AU  - Lombardi,G
AU  - Afzali,B
DO  - 10.7554/eLife.14814.001
EP  - 1414
PY  - 2018///
SN  - 1529-2908
SP  - 1403
TI  - Human retinoic acid-regulated CD161(+) regulatory T cells support wound repair in intestinal mucosa
T2  - Nature Immunology
UR  - http://dx.doi.org/10.7554/eLife.14814.001
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000452873000020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.nature.com/articles/s41590-018-0230-z
UR  - http://hdl.handle.net/10044/1/91977
VL  - 19
ER  -
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