Imperial College London

DrNicholasCroucher

Faculty of MedicineSchool of Public Health

Senior Lecturer in Bacterial Genomics
 
 
 
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Contact

 

+44 (0)20 7594 3820n.croucher

 
 
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Location

 

UG5Norfolk PlaceSt Mary's Campus

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Summary

 

Summary

I am a Sir Henry Dale fellow in the Bacterial Evolutionary Epidemiology group at the MRC Centre for Global Infectious Disease Analysis, near Paddington. My work focusses on the biology of multi-strain bacterial populations, primarily Streptococcus pneumoniae (the pneumococcus). Such microbes often vary extensively in characteristics such as antibiotic resistance, virulence and expression of antigens that are potential vaccine targets. To understand this variation, my research encompasses laboratory molecular microbiology, analysis of genomic datasets, and computational modelling. Repeated emails are the best way to contact me.

Publications

Journals

Zamudio R, Haigh RD, Ralph JD, et al., 2020, Lineage-specific evolution and gene flow inListeria monocytogenesare independent of bacteriophages, Environmental Microbiology, ISSN:1462-2912

Harrow GL, Lees JA, Hanage WP, et al., 2020, Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures

Gladstone RA, Lo SW, Goater R, et al., 2020, Visualizing variation within Global Pneumococcal Sequence Clusters (GPSCs) and country population snapshots to contextualize pneumococcal isolates, Microbial Genomics, Vol:6, ISSN:2057-5858

Lehtinen S, Chewapreecha C, Lees J, et al., 2020, Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae, Science Advances, Vol:6, ISSN:2375-2548

Colijn C, Corander J, Croucher NJ, 2020, Designing ecologically optimized pneumococcal vaccines using population genomics, Nature Microbiology, Vol:5, ISSN:2058-5276, Pages:473-485

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