Imperial College London

DrNicholasCroucher

Faculty of MedicineSchool of Public Health

Reader in Bacterial Genomics
 
 
 
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Contact

 

+44 (0)20 7594 3820n.croucher

 
 
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Location

 

1104Building E - Sir Michael UrenWhite City Campus

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Summary

 

Summary

I am a Sir Henry Dale fellow in the Bacterial Evolutionary Epidemiology group at the MRC Centre for Global Infectious Disease Analysis, near Paddington. My work focusses on the biology of multi-strain bacterial populations, primarily Streptococcus pneumoniae (the pneumococcus). Such microbes often vary extensively in characteristics such as antibiotic resistance, virulence and expression of antigens that are potential vaccine targets. To understand this variation, my research encompasses laboratory molecular microbiology, analysis of genomic datasets, and computational modelling. Repeated emails are the best way to contact me.

Publications

Journals

Croucher NJ, Campo JJ, Le TQ, et al., 2024, Genomic and panproteomic analysis of the development of infant immune responses to antigenically-diverse pneumococci, Nature Communications, Vol:15, ISSN:2041-1723

Kwun MJ, Ion A, Oggioni MR, et al., 2023, Diverse regulatory pathways modulate bet hedging of competence induction in epigenetically-differentiated phase variants of Streptococcus pneumoniae, Nucleic Acids Research, ISSN:0305-1048

Horsfield ST, Tonkin-Hill G, Croucher NJ, et al., 2023, Accurate and fast graph-based pangenome annotation and clustering with ggCaller., Genome Res, Vol:33, Pages:1622-1637

Horsfield ST, Croucher NJ, Lees JA, 2023, Accurate and fast graph-based pangenome annotation and clustering with ggCaller

Glanville DG, Gazioglu O, Marra M, et al., 2023, Pneumococcal capsule expression is controlled through a conserved, distal <i>cis</i>-regulatory element during infection, Plos Pathogens, Vol:19, ISSN:1553-7366

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