I am a Sir Henry Dale fellow in the Bacterial Evolutionary Epidemiology group at the MRC Centre for Global Infectious Disease Analysis, near Paddington. My work focusses on the biology of multi-strain bacterial populations, primarily Streptococcus pneumoniae (the pneumococcus). Such microbes often vary extensively in characteristics such as antibiotic resistance, virulence and expression of antigens that are potential vaccine targets. To understand this variation, my research encompasses laboratory molecular microbiology, analysis of genomic datasets, and computational modelling. Repeated emails are the best way to contact me.
Horsfield ST, Croucher NJ, Lees JA, 2023, Accurate and fast graph-based pangenome annotation and clustering with ggCaller
et al., 2022, Post-vaccine epidemiology of serotype 3 pneumococci identifies transformation inhibition through prophage-driven alteration of a non-coding RNA, Genome Medicine: Medicine in the Post-genomic Era, Vol:14, ISSN:1756-994X
et al., 2022, Pneumococcal within-host diversity during colonization, transmission and treatment, Nature Microbiology, Vol:7, ISSN:2058-5276, Pages:1791-+
et al., 2022, Genome-wide association, prediction and heritability in bacteria with application to Streptococcus pneumoniae, Nar Genomics and Bioinformatics, Vol:4, ISSN:2631-9268, Pages:1-11
et al., 2022, RCandy: an R package for visualizing homologous recombinations in bacterial genomes, Bioinformatics, Vol:38, ISSN:1367-4803, Pages:1450-1451