I am a Sir Henry Dale fellow in the Bacterial Evolutionary Epidemiology group at the MRC Centre for Global Infectious Disease Analysis, near Paddington. My work focusses on the biology of multi-strain bacterial populations, primarily Streptococcus pneumoniae (the pneumococcus). Such microbes often vary extensively in characteristics such as antibiotic resistance, virulence and expression of antigens that are potential vaccine targets. To understand this variation, my research encompasses laboratory molecular microbiology, analysis of genomic datasets, and computational modelling. Repeated emails are the best way to contact me.
et al., 2024, Genomic and panproteomic analysis of the development of infant immune responses to antigenically-diverse pneumococci, Nature Communications, Vol:15, ISSN:2041-1723
et al., 2023, Diverse regulatory pathways modulate bet hedging of competence induction in epigenetically-differentiated phase variants of Streptococcus pneumoniae, Nucleic Acids Research, ISSN:0305-1048
et al., 2023, Accurate and fast graph-based pangenome annotation and clustering with ggCaller., Genome Res, Vol:33, Pages:1622-1637
Horsfield ST, Croucher NJ, Lees JA, 2023, Accurate and fast graph-based pangenome annotation and clustering with ggCaller
et al., 2023, Pneumococcal capsule expression is controlled through a conserved, distal <i>cis</i>-regulatory element during infection, Plos Pathogens, Vol:19, ISSN:1553-7366