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@article{Dewe:2019:10.1099/mgen.0.000305,
author = {Dewe, TCM and D'Aetht, JC and Croucher, NJ},
doi = {10.1099/mgen.0.000305},
journal = {Microbial Genomics},
pages = {1--8},
title = {Genomic epidemiology of penicillin-non-susceptible Streptococcus pneumoniae},
url = {http://dx.doi.org/10.1099/mgen.0.000305},
volume = {5},
year = {2019}
}

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TY  - JOUR
AB  - Penicillin-non-susceptible Streptococcus pneumoniae (PNSP) were first detected in the 1960s, and are now common worldwide, predominantly through the international spread of a limited number of strains. Extant PNSP are characterized by mosaic pbp2x, pbp2b and pbp1a genes generated by interspecies recombinations, with the extent of these alterations determining the range and concentrations of β-lactams to which the genotype is non-susceptible. The complexity of the genetics underlying these phenotypes has been the subject of both molecular microbiology and genome-wide association and epistasis analyses. Such studies can aid our understanding of PNSP evolution and help improve the already highly-performing bioinformatic methods capable of identifying PNSP from genomic surveillance data.
AU  - Dewe,TCM
AU  - D'Aetht,JC
AU  - Croucher,NJ
DO  - 10.1099/mgen.0.000305
EP  - 8
PY  - 2019///
SN  - 2057-5858
SP  - 1
TI  - Genomic epidemiology of penicillin-non-susceptible Streptococcus pneumoniae
T2  - Microbial Genomics
UR  - http://dx.doi.org/10.1099/mgen.0.000305
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000493924700002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.microbiologyresearch.org/content/journal/mgen/10.1099/mgen.0.000305
UR  - http://hdl.handle.net/10044/1/75997
VL  - 5
ER  -

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