Publications
142 results found
Ricciuto A, Al-Darmaki A, Stewart MJ, et al., 2018, Biological interventions for induction and maintenance of mucosal healing in ulcerative colitis: A Cochrane systematic review, Publisher: OXFORD UNIV PRESS, Pages: S335-S336, ISSN: 1873-9946
Wu K, Thompson A, Ding NS, 2018, Risk of colorectal neoplasia, colectomy and responsiveness to biologic therapy in patients with inflammatory bowel disease and concomitant primary sclerosing cholangitis: A systematic review, Publisher: OXFORD UNIV PRESS, Pages: S244-S245, ISSN: 1873-9946
Bettenworth D, Muecke M, Singh A, et al., 2018, Efficacy, safety and long-term outcome of endoscopic dilation therapy for Crohn's disease strictures of the upper gastrointestinal tract: an international multicentre cohort study including 99 patients with 129 dilation procedures, Publisher: OXFORD UNIV PRESS, Pages: S61-S62, ISSN: 1873-9946
Segal J, McLaughlin S, Penez L, et al., 2018, P141 Infliximab therapy for inflammatory pouch pathology: a multi-centre retrospective study, 13th Congress of ECCO – European Crohn’s and Colitis Organisation, Publisher: Oxford University Press (OUP), Pages: S167-S167, ISSN: 1873-9946
Ding NS, Malietzis G, Hart AL, 2018, Editorial: anti-TNF therapy and myopenia in Crohn's diseaseanother step towards personalised medicine. Authors' reply, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 47, Pages: 142-143, ISSN: 0269-2813
Ding NS, Malietzis G, Lung PFC, et al., 2017, The body composition profile is associated with response to anti-TNF therapy in Crohn's disease and may offer an alternative dosing paradigm, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 46, Pages: 883-891, ISSN: 0269-2813
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- Citations: 48
Lindsay JO, Irving PM, Mantzaris GJ, et al., 2017, ECCO IBD Curriculum, JOURNAL OF CROHNS & COLITIS, Vol: 11, Pages: 1039-1043, ISSN: 1873-9946
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- Citations: 5
Cunningham G, Macisaac M, Ding N, et al., 2017, Colectomy rates remain high in the era of rescue therapy for acute severe ulcerative colitis: A single-center experience, Publisher: WILEY, Pages: 124-124, ISSN: 0815-9319
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- Citations: 1
Ding NS, Yazdanian B, Bettenworth D, et al., 2017, Assessing access to investigations in inflammatory bowel disease (ACCID): Results from an international inflammatory bowel disease survey, Publisher: WILEY, Pages: 125-125, ISSN: 0815-9319
Ding NS, Perdones-Montero A, Sarafian M, et al., 2017, The microbiota and it's role in anti-TNF therapy non-response, Publisher: OXFORD UNIV PRESS, Pages: S482-S483, ISSN: 1873-9946
Ding NS, Perdones-Montero A, Sarafian M, et al., 2017, The microbiota and it's role in anti-TNF therapy non-response, Publisher: OXFORD UNIV PRESS, Pages: S482-S483, ISSN: 1873-9946
Ding NS, Sarafian M, Perdones-Montero A, et al., 2017, Complete metabonomic and microbiota profiling identifies biomarkers for anti-TNF therapy response, Publisher: OXFORD UNIV PRESS, Pages: S88-S89, ISSN: 1873-9946
Ding NS, Yazdanian B, Bettenworth D, et al., 2017, Assessing aCCess to investigations in IBD (ACCID) - results from an international inflammatory bowel disease survey, Publisher: OXFORD UNIV PRESS, Pages: S458-S459, ISSN: 1873-9946
Doecke JD, Hartnell F, Bampton P, et al., 2017, Infliximab vs. adalimumab in Crohn's disease: results from 327 patients in an Australian and New Zealand observational cohort study, ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Vol: 45, Pages: 542-552, ISSN: 0269-2813
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- Citations: 33
Sarafian MH, Ding NS, Holmes E, et al., 2017, Effect on the Host Metabolism, MICROBIOTA IN GASTROINTESTINAL PATHOPHYSIOLOGY: IMPLICATIONS FOR HUMAN HEALTH, PREBIOTICS, PROBIOTICS, AND DYSBIOSIS, Editors: Floch, Ringel, Walker, Publisher: ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, Pages: 249-253, ISBN: 978-0-12-804024-9
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- Citations: 2
Segal JP, Ding NS, Worley G, et al., 2016, Systematic review with meta-analysis: the management of chronic refractory pouchitis with an evidence-based treatment algorithm, Alimentary Pharmacology and Therapeutics, Vol: 45, Pages: 581-592, ISSN: 0269-2813
BACKGROUND: Restorative proctocolectomy with ileal pouch anal anastomosis (IPAA) is considered the procedure of choice in patients with ulcerative colitis (UC) refractory to medical therapy. The incidence of pouchitis is 40% at 5 years. Ten to 15% of patients with pouchitis experience chronic pouchitis. AIM: To determine the efficacy of medical therapies for the treatment of chronic refractory pouchitis in patients undergoing IPAA for UC. METHODS: A systematic computer-assisted search of the on-line bibliographic database MEDLINE and EMBASE was performed between 1966 and February 2016. All original studies reporting remission rates following medical treatment for chronic pouchitis were included. All study designs were considered. Remission was defined according to the individual study. Remission endpoints ranged from 15 days to 10 weeks. Chronic pouchitis was defined by each study. RESULTS: Twenty-one papers were considered eligible. Results from all studies combined suggested that overall remission was obtained in 59% of patients (95% CI: 44-73%). Antibiotics significantly induced remission in patients with chronic pouchitis with 74% remission rate (95% CI:56-93%), (P < 0.001). Biologics significantly induced remission in patients with chronic pouchitis with 53% remission rate (95% CI:30-76%), (P < 0.001). Steroids, bismuth, elemental diet and tacrolimus all can induce remission but failed to achieve significance. Faecal microbiota transplantation in a single study was not found to achieve remission. CONCLUSIONS: Treatment of chronic refractory pouchitis remains difficult and is largely empirical. Larger randomised controlled trials will help aid the management of chronic pouchitis.
Ding N, Mullish BH, McLaughlin J, et al., 2016, Meeting update: faecal microbiota transplantation––bench, bedside, courtroom?, Frontline Gastroenterology, Vol: 9, Pages: 45-48, ISSN: 2041-4145
A group of stakeholders met, underthe aegis of the British Society ofGastroenterology, to discuss the currentlandscape of faecal microbiota transplant-ation (FMT) within the UK and beyond.The meeting covered a wide range oftopics, ranging from the practical aspectsof establishing an FMT service and regu-latory issues relating to its delivery, toresearch implications and likely futuredirections.
Ding NS, Sarafian M, Misra R, et al., 2016, Metabolic profiling of urine and faeces differentiates inflammatory bowel disease phenotype and has implications on therapeutic response, JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol: 31, Pages: 123-124, ISSN: 0815-9319
Choi CHR, Ding NS, Al Bakir I, et al., 2016, Persistently active inflammation is a risk factor for colorectal neoplasia in ulcerative colitis: Results from the largest colonoscopic surveillance program, Publisher: WILEY-BLACKWELL, Pages: 129-130, ISSN: 0815-9319
Ding NS, Sarafian M, Misra R, et al., 2016, Lipid biomarker as a diagnostic tool in Crohn's disease using metabonomic profiling in serum and faeces, Publisher: WILEY-BLACKWELL, Pages: 122-123, ISSN: 0815-9319
Ding N, Hart A, 2016, Inflammatory bowel disease and the gut microbiota, The Human Microbiota and Chronic Disease: Dysbiosis as a Cause of Human Pathology, Pages: 301-315, ISBN: 9781118982877
This chapter outlines the major Inflammatory bowel disease (IBD) patient studies in relation to dysbiosis mechanisms, recent research progress from 16S-based studies linking specific organisms with disease, and studies of the microbiota and its future applications with regard to metagenomics and metabolomics. Maximal microbial assembly stability and complexity is reached in adulthood, and then any variations are few and minor. This stability decreases in elderly subjects. At the phylogenetic level, there is generally high variability over time in the human microbiota, both between and within individual subjects. IBD pathogenesis may result from dysregulation of the mucosal immune system, driving a pathogenic immune response against commensal gut flora. Significant improvements in DNA sequencing technology and analysis over the past decade have set the stage for IBD microbiome investigations. Specific taxonomic shifts have been reported in IBD. Enterobacteriaceae are increased in relative abundance, both in IBD patients and in mouse models.
Ding NS, Malietzis G, Lung PF, et al., 2016, BODY COMPOSITION PROFILING IS A PREDICTOR OF THERAPEUTIC OUTCOME IN PATIENTS WITH MODERATE TO SEVERE CROHN'S DISEASE, GUT, Vol: 65, Pages: A85-A85, ISSN: 0017-5749
Choi CHR, Al Bakir I, Ding NSJ, et al., 2016, RISK FACTORS FOR COLORECTAL NEOPLASIA IN ULCERATIVE COLITIS: RESULTS FROM THE LARGEST AND LONGEST-RUNNING COLONOSCOPIC SURVEILLANCE PROGRAM, GUT, Vol: 65, Pages: A38-A39, ISSN: 0017-5749
Ding NS, Sarafian M, Misra R, et al., 2016, LIPID BIOMARKER AS A DIAGNOSTIC TOOL IN CROHN'S DISEASE USING METABONOMIC PROFILING IN SERUM AND FAECES, GUT, Vol: 65, Pages: A85-A85, ISSN: 0017-5749
Ding NS, Malietzis G, Lung PF, et al., 2016, 186 Body Composition Profile: A Predictor of Therapeutic Outcome in Patients With Moderate to Severe Crohn’s Disease, AGA, Publisher: Elsevier, Pages: S48-S49, ISSN: 0016-5085
Ding NS, Sarafian M, Misra R, et al., 2016, Su1805 Lipid Biomarker: Diagnostic Approach to Crohn’s Disease Using Metabonomic Profiling in Serum and Faeces, 2016 Digestive Diseases Week, Publisher: Elsevier, Pages: S557-S557, ISSN: 0016-5085
Ding NS, Malietzis G, Lung PF, et al., 2016, Body Composition Profile: A Predictor of Therapeutic Outcome in Patients With Moderate to Severe Crohn's Disease, Digestive Disease Week (DDW), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S48-S49, ISSN: 0016-5085
Ding NS, Sarafian M, Misra R, et al., 2016, Lipid Biomarker: Diagnostic Approach to Crohn's Disease Using Metabonomic Profiling in Serum and Faeces, 57th Annual Meeting and Residents Fellow Conference of the Society-for-Surgery-of-the-Alimentary-Tract (SSAT) / 52nd Annual Meeting on Digestive Disease Week (DDW) / Meeting of the American-Gastroenterological-Association (AGA), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S557-S557, ISSN: 0016-5085
Ding NS, Yip W, Choi R, et al., 2016, Escalation of medical therapy decreases need for repeat dilatation in Crohn’s anastomatic strictures
Ding NS, Sarafian M, Misra R, et al., 2016, Lipid biomarkers to diagnose Crohn's disease using metabonomic profiling approach in serum and faeces, JOURNAL OF CROHNS & COLITIS, Vol: 10, Pages: S93-S93, ISSN: 1873-9946
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