Publications
142 results found
Ding NS, Malietzis G, Lung PF, et al., 2016, Body composition: a biomarker of therapeutic outcome in patients with Crohn's disease, JOURNAL OF CROHNS & COLITIS, Vol: 10, Pages: S402-S403, ISSN: 1873-9946
Yarrow H, O'Connor M, Ding N, et al., 2016, Postoperative Crohn's care: a consistent approach?, Publisher: OXFORD UNIV PRESS, Pages: S501-S502, ISSN: 1873-9946
Su M, Chen H, Zhi M, et al., 2016, Clostridium difficile infection in inflammatory bowel disease patients: prevalence and risk factors, Publisher: OXFORD UNIV PRESS, Pages: S487-S488, ISSN: 1873-9946
Yang Q, Gao X, Zhi M, et al., 2016, Efficacy of exclusive enteral nutrition in adult active Crohn's disease with complications or failure of medical treatment, Publisher: OXFORD UNIV PRESS, Pages: S64-S65, ISSN: 1873-9946
Kennedy NA, Warner B, Johnston EL, et al., 2016, Relapse after withdrawal from anti-TNF therapy for inflammatory bowel disease: an observational study, plus systematic review and meta-analysis, Alimentary pharmacology & therapeutics
Ding NS, Yip WM, Choi CH, et al., 2016, Endoscopic Dilatation of Crohn’s Anastomotic Strictures is Effective in the Long Term, and Escalation of Medical Therapy Improves Outcomes in the Biologic Era, Journal of Crohn’s and Colitis, Pages: jjw072-jjw072
Ding NS, Nguyen T, Iser DM, et al., 2016, Liver stiffness plus platelet count can be used to exclude high-risk oesophageal varices, Liver International, Vol: 36, Pages: 240-245
Ding NS, Hart A, De Cruz P, 2015, Systematic review: predicting and optimising response to anti-TNF therapy in Crohn’s disease–algorithm for practical management, Alimentary Pharmacology & Therapeutics, Vol: 43, Pages: 30-51, ISSN: 1365-2036
BackgroundNonresponse and loss of response to anti-TNF therapies in Crohn's disease represent significant clinical problems for which clear management guidelines are lacking.AimTo review the incidence, mechanisms and predictors of primary nonresponse and secondary loss of response to formulate practical clinical algorithms to guide management.MethodsThrough a systematic literature review, 503 articles were identified which fit the inclusion criteria.ResultsPrimary nonresponse to anti-TNF treatment affects 13–40% of patients. Secondary loss of response to anti-TNF occurs in 23–46% of patients when determined according to dose intensification, and 5–13% of patients when gauged by drug discontinuation rates. Recent evidence suggests that the mechanisms underlying primary nonresponse and secondary loss of response are multifactorial and include disease characteristics (phenotype, location, severity); drug (pharmacokinetic, pharmacodynamic or immunogenicity) and treatment strategy (dosing regimen) related factors. Clinical algorithms that employ therapeutic drug monitoring (using anti-TNF tough levels and anti-drug antibody levels) may be used to determine the underlying cause of primary nonresponse and secondary loss of response respectively and guide clinicians as to which patients are most likely to respond to anti-TNF therapy and help optimise drug therapy for those who are losing response to anti-TNF therapy.ConclusionsNonresponse or loss of response to anti-TNF occurs commonly in Crohn's disease. Clinical algorithms utilising therapeutic drug monitoring may establish the mechanisms for treatment failure and help guide the subsequent therapeutic approach.
, 2015, UEG Week 2015 Oral Presentations, United European Gastroenterology Journal, Vol: 3, Pages: 1-145, ISSN: 2050-6406
Hendy P, Ding N, 2015, Journal watch-a new laboratory-based algorithm to predict development of hepatocellular carcinoma in patients with hepatitis C and cirrhosis, FRONTLINE GASTROENTEROLOGY, Vol: 6, Pages: 154-155, ISSN: 2041-4137
Ding NSJ, Yip WM, Saunders BP, et al., 2015, Sa1227 Long Term Outcomes of Crohn's Anastamotic Strictures Treated With Endoscopic Balloon Dilatation, Publisher: Elsevier BV, Pages: S-263, ISSN: 0016-5085
Niewiadomski O, Studd C, Wilson CHJ, et al., 2015, The First Prospective Australian Population-Based Study of Newly Diagnosed IBD Identifies Frequent Use of Immunomodulators, Low Surgery Rates and High Cost From Medications and Investigations, 46th Annual Digestive Disease Week (DDW), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S471-S471, ISSN: 0016-5085
Kennedy NA, Warner BD, Johnston E, et al., 2015, Anti-TNF Withdrawal in IBD: Relapse and Recapture Rates and Predictive Factors From 160 Patients in a Pan-UK Study, 46th Annual Digestive Disease Week (DDW), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S62-S62, ISSN: 0016-5085
Hendy PA, Bernardo D, Al-Hassi HO, et al., 2015, PTH-057 Dendritic cell phenotype in crohn’s disease may correlate with disease severity and explain the high prevalence of cutaneous manifestations, Publisher: BMJ Publishing Group Ltd and British Society of Gastroenterology, Pages: A430-A431
Ding N, Yip WM, Saunders B, et al., 2015, PWE-072 Long-term outcome of endoscopic dilatation in patients with crohn’s anastomotic strictures is affected by disease activity and medical therapy, Publisher: BMJ Publishing Group Ltd and British Society of Gastroenterology, Pages: A243-A244
Ding N, Yassin N, Hart A, 2015, PWE-073 Metabonomics and it–s use in inflammatory bowel disease (ibd): a systematic review, Publisher: BMJ Publishing Group Ltd and British Society of Gastroenterology, Pages: A244-A244
Singh S, Ding NS, 2015, Letter: faecal diversion for severe perianal Crohn’s disease–practical issues. Authors’ reply, Alimentary pharmacology & therapeutics, Vol: 42, Pages: 1237-1237
Ding NS, Yassin NA, Hart A, 2015, Systematic Review of the use of metabonomics in inflammatory bowel disease (IBD), Pages: S99-S100
Niewiadomski O, Studd C, Hair C, et al., 2015, Prospective population-based cohort of inflammatory bowel disease in the biologics era: Disease course and predictors of severity, Journal of gastroenterology and hepatology, Vol: 30, Pages: 1346-1353
Ding NS, Yip W, Hanna M, et al., 2015, Five year outcomes of Crohn’s anastamotic strictures treated with balloon dilatation, JOURNAL OF CROHNS & COLITIS, Vol: 9, Pages: S285-S285
Ding NSJ, Yip WM, Saunders BP, et al., 2015, Sa1227 Long Term Outcomes of Crohn’s Anastamotic Strictures Treated With Endoscopic Balloon Dilatation, Publisher: Elsevier, Pages: S-263
Niewiadomski O, Studd C, Hair C, et al., 2015, Su1312 The First Prospective Australian Population-Based Study of Newly Diagnosed IBD Identifies Frequent Use of Immunomodulators, Low Surgery Rates and High Cost From Medications and Investigations, Gastroenterology, Vol: 148, Pages: S-471
Kennedy NA, Warner BD, Johnston E, et al., 2015, 288 Anti-TNF Withdrawal in IBD: Relapse and Recapture Rates and Predictive Factors From 160 Patients in a Pan-UK Study, Gastroenterology, Vol: 148, Pages: S-62
Singh S, Ding NS, Mathis KL, et al., 2015, Systematic review with meta-analysis: faecal diversion for management of perianal Crohn’s disease, Alimentary pharmacology & therapeutics, Vol: 42, Pages: 783-792
Ding NS, Mohammad S, Hendy P, et al., 2015, Five year outcomes of Crohn’s small bowel strictures treated with double balloon enteroscopic dilatation., JOURNAL OF CROHNS & COLITIS, Vol: 9, Pages: S338-S339
Hendy P, Ding N, 2015, Probiotics for secondary prevention of hepatic encephalopathy, Frontline Gastroenterology, Vol: 6, Pages: 230-231
Crowe A, Ding NS, Yong E, et al., 2014, <i>Rothia aeria</i> mitral valve endocarditis complicated by multiple mycotic aneurysms: laboratory identification expedited using MALDI-TOF MS, INFECTION, Vol: 42, Pages: 419-423, ISSN: 0300-8126
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- Citations: 9
Ding NS, Kemp W, Nguyen T, et al., 2014, Mo1009 Elastography Plus Platelet Count Rather Than Endoscopy to Screen for Clinically Significant Esophageal Varices, Publisher: Elsevier, Pages: S-984
Niewiadomski O, Studd C, Hair C, et al., 2014, The first prospective Australian population-based natural history study of newly diagnosed IBD identifies frequent use of immunomodulators and low surgery rates, Pages: 119-120
Hendy P, Ding N, 2014, Journal watch—a new laboratory-based algorithm to predict development of hepatocellular carcinoma in patients with hepatitis C and cirrhosis, Frontline Gastroenterology, Pages: flgastro-2014
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